ID CREB_ECOLI Reviewed; 229 AA.
AC P08368; Q2M5R9;
DT 01-AUG-1988, integrated into UniProtKB/Swiss-Prot.
DT 01-AUG-1988, sequence version 1.
DT 01-MAY-2013, entry version 114.
DE RecName: Full=Transcriptional regulatory protein CreB;
GN Name=creB; Synonyms=yjjE; OrderedLocusNames=b4398, JW4361;
OS Escherichia coli (strain K12).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacteriales;
OC Enterobacteriaceae; Escherichia.
OX NCBI_TaxID=83333;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=3531171;
RA Amemura M., Makino K., Shinagawa H., Nakata A.;
RT "Nucleotide sequence of the phoM region of Escherichia coli: four open
RT reading frames may constitute an operon.";
RL J. Bacteriol. 168:294-302(1986).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / MG1655 / ATCC 47076;
RX PubMed=7610040; DOI=10.1093/nar/23.12.2105;
RA Burland V.D., Plunkett G. III, Sofia H.J., Daniels D.L.,
RA Blattner F.R.;
RT "Analysis of the Escherichia coli genome VI: DNA sequence of the
RT region from 92.8 through 100 minutes.";
RL Nucleic Acids Res. 23:2105-2119(1995).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / MG1655 / ATCC 47076;
RX PubMed=9278503; DOI=10.1126/science.277.5331.1453;
RA Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V.,
RA Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F.,
RA Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J.,
RA Mau B., Shao Y.;
RT "The complete genome sequence of Escherichia coli K-12.";
RL Science 277:1453-1474(1997).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX PubMed=16738553; DOI=10.1038/msb4100049;
RA Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S.,
RA Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.;
RT "Highly accurate genome sequences of Escherichia coli K-12 strains
RT MG1655 and W3110.";
RL Mol. Syst. Biol. 2:E1-E5(2006).
RN [5]
RP PHOSPHORYLATION.
RC STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX PubMed=15522865; DOI=10.1074/jbc.M410104200;
RA Yamamoto K., Hirao K., Oshima T., Aiba H., Utsumi R., Ishihama A.;
RT "Functional characterization in vitro of all two-component signal
RT transduction systems from Escherichia coli.";
RL J. Biol. Chem. 280:1448-1456(2005).
CC -!- FUNCTION: Member of the two-component regulatory system CreC/CreB
CC involved in catabolic regulation.
CC -!- SUBCELLULAR LOCATION: Cytoplasm (Probable).
CC -!- PTM: Phosphorylated by CreC.
CC -!- SIMILARITY: Contains 1 response regulatory domain.
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DR EMBL; M13608; AAA24374.1; -; Genomic_DNA.
DR EMBL; U14003; AAA97294.1; -; Genomic_DNA.
DR EMBL; U00096; AAC77351.1; -; Genomic_DNA.
DR EMBL; AP009048; BAE78387.1; -; Genomic_DNA.
DR PIR; B25038; QQECFJ.
DR RefSeq; NP_418815.1; NC_000913.2.
DR RefSeq; YP_492528.1; NC_007779.1.
DR ProteinModelPortal; P08368; -.
DR SMR; P08368; 4-227.
DR DIP; DIP-9318N; -.
DR IntAct; P08368; 1.
DR STRING; 511145.b4398; -.
DR EnsemblBacteria; AAC77351; AAC77351; b4398.
DR EnsemblBacteria; BAE78387; BAE78387; BAE78387.
DR GeneID; 12934258; -.
DR GeneID; 948922; -.
DR KEGG; ecj:Y75_p4282; -.
DR KEGG; eco:b4398; -.
DR PATRIC; 32124414; VBIEscCol129921_4547.
DR EchoBASE; EB1201; -.
DR EcoGene; EG11218; creB.
DR eggNOG; COG0745; -.
DR HOGENOM; HOG000034819; -.
DR KO; K07663; -.
DR OMA; CARVRTI; -.
DR ProtClustDB; PRK11083; -.
DR BioCyc; EcoCyc:CREB-MONOMER; -.
DR BioCyc; ECOL316407:JW4361-MONOMER; -.
DR Genevestigator; P08368; -.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0000156; F:phosphorelay response regulator activity; IEA:InterPro.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:GOC.
DR GO; GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.
DR GO; GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
DR Gene3D; 1.10.10.10; -; 1.
DR InterPro; IPR011006; CheY-like_superfamily.
DR InterPro; IPR001867; Sig_transdc_resp-reg_C.
DR InterPro; IPR001789; Sig_transdc_resp-reg_receiver.
DR InterPro; IPR011991; WHTH_DNA-bd_dom.
DR Pfam; PF00072; Response_reg; 1.
DR Pfam; PF00486; Trans_reg_C; 1.
DR SMART; SM00448; REC; 1.
DR SMART; SM00862; Trans_reg_C; 1.
DR SUPFAM; SSF52172; CheY_like; 1.
DR PROSITE; PS50110; RESPONSE_REGULATORY; 1.
PE 1: Evidence at protein level;
KW Complete proteome; Cytoplasm; DNA-binding; Phosphoprotein;
KW Reference proteome; Transcription; Transcription regulation;
KW Two-component regulatory system.
FT CHAIN 1 229 Transcriptional regulatory protein CreB.
FT /FTId=PRO_0000081082.
FT DOMAIN 1 119 Response regulatory.
FT MOD_RES 54 54 4-aspartylphosphate (By similarity).
SQ SEQUENCE 229 AA; 26125 MW; A982C6D832C7607B CRC64;
MQRETVWLVE DEQGIADTLV YMLQQEGFAV EVFERGLPVL DKARKQVPDV MILDVGLPDI
SGFELCRQLL ALHPALPVLF LTARSEEVDR LLGLEIGADD YVAKPFSPRE VCARVRTLLR
RVKKFSTPSP VIRIGHFELN EPAAQISWFD TPLALTRYEF LLLKTLLKSP GRVWSRQQLM
DSVWEDAQDT YDRTVDTHIK TLRAKLRAIN PDLSPINTHR GMGYSLRGL
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