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Database: UniProt
Entry: P0A4P5
LinkDB: P0A4P5
Original site: P0A4P5 
ID   UNG_STRA1               Reviewed;         217 AA.
AC   P0A4P5; Q3K0U4; Q9XDS8;
DT   15-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT   15-MAR-2005, sequence version 1.
DT   01-OCT-2014, entry version 61.
DE   RecName: Full=Uracil-DNA glycosylase;
DE            Short=UDG;
DE            EC=3.2.2.27;
GN   Name=ung; OrderedLocusNames=SAK_1245;
OS   Streptococcus agalactiae serotype Ia (strain ATCC 27591 / A909 / CDC
OS   SS700).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC   Streptococcus.
OX   NCBI_TaxID=205921;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=OI1 / Serotype Ia;
RX   PubMed=10464185;
RA   Yamamoto S., Miyake K., Koike Y., Watanabe M., Machida Y., Ohta M.,
RA   Iijima S.;
RT   "Molecular characterization of type-specific capsular polysaccharide
RT   biosynthesis genes of Streptococcus agalactiae type Ia.";
RL   J. Bacteriol. 181:5176-5184(1999).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 27591 / A909 / CDC SS700;
RX   PubMed=16172379; DOI=10.1073/pnas.0506758102;
RA   Tettelin H., Masignani V., Cieslewicz M.J., Donati C., Medini D.,
RA   Ward N.L., Angiuoli S.V., Crabtree J., Jones A.L., Durkin A.S.,
RA   DeBoy R.T., Davidsen T.M., Mora M., Scarselli M., Margarit y Ros I.,
RA   Peterson J.D., Hauser C.R., Sundaram J.P., Nelson W.C., Madupu R.,
RA   Brinkac L.M., Dodson R.J., Rosovitz M.J., Sullivan S.A.,
RA   Daugherty S.C., Haft D.H., Selengut J., Gwinn M.L., Zhou L., Zafar N.,
RA   Khouri H., Radune D., Dimitrov G., Watkins K., O'Connor K.J.,
RA   Smith S., Utterback T.R., White O., Rubens C.E., Grandi G.,
RA   Madoff L.C., Kasper D.L., Telford J.L., Wessels M.R., Rappuoli R.,
RA   Fraser C.M.;
RT   "Genome analysis of multiple pathogenic isolates of Streptococcus
RT   agalactiae: implications for the microbial 'pan-genome'.";
RL   Proc. Natl. Acad. Sci. U.S.A. 102:13950-13955(2005).
CC   -!- FUNCTION: Excises uracil residues from the DNA which can arise as
CC       a result of misincorporation of dUMP residues by DNA polymerase or
CC       due to deamination of cytosine. {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY: Hydrolyzes single-stranded DNA or mismatched
CC       double-stranded DNA and polynucleotides, releasing free uracil.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the uracil-DNA glycosylase family.
CC       {ECO:0000305}.
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DR   EMBL; AB028896; BAA82292.1; -; Genomic_DNA.
DR   EMBL; CP000114; ABA45529.1; -; Genomic_DNA.
DR   RefSeq; WP_000682955.1; NC_007432.1.
DR   RefSeq; YP_329859.1; NC_007432.1.
DR   ProteinModelPortal; P0A4P5; -.
DR   SMR; P0A4P5; 3-215.
DR   STRING; 205921.SAK_1245; -.
DR   EnsemblBacteria; ABA45529; ABA45529; SAK_1245.
DR   GeneID; 3686843; -.
DR   KEGG; sak:SAK_1245; -.
DR   PATRIC; 19633765; VBIStrAga82541_1189.
DR   eggNOG; COG0692; -.
DR   HOGENOM; HOG000229528; -.
DR   KO; K03648; -.
DR   OMA; WARQGVM; -.
DR   OrthoDB; EOG6MSS63; -.
DR   BioCyc; SAGA205921:GHD7-1246-MONOMER; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0004844; F:uracil DNA N-glycosylase activity; IEA:UniProtKB-HAMAP.
DR   GO; GO:0006284; P:base-excision repair; IEA:UniProtKB-HAMAP.
DR   Gene3D; 3.40.470.10; -; 1.
DR   HAMAP; MF_00148; UDG; 1.
DR   InterPro; IPR018085; Ura-DNA_Glyclase_AS.
DR   InterPro; IPR002043; Ura_DNA_glycsylse.
DR   InterPro; IPR005122; Uracil-DNA_glycosylase-like.
DR   PANTHER; PTHR11264; PTHR11264; 1.
DR   Pfam; PF03167; UDG; 1.
DR   SMART; SM00986; UDG; 1.
DR   SUPFAM; SSF52141; SSF52141; 1.
DR   TIGRFAMs; TIGR00628; ung; 1.
DR   PROSITE; PS00130; U_DNA_GLYCOSYLASE; 1.
PE   3: Inferred from homology;
KW   Complete proteome; Cytoplasm; DNA damage; DNA repair; Glycosidase;
KW   Hydrolase.
FT   CHAIN         1    217       Uracil-DNA glycosylase.
FT                                /FTId=PRO_0000176144.
FT   ACT_SITE     62     62       Proton acceptor. {ECO:0000250}.
SQ   SEQUENCE   217 AA;  24570 MW;  EC6C29EF8732895B CRC64;
     MKHSSWHDLI KRELPNHYYN KINTFMDAVY ESGIVYPPRD KVFNAIQITP LENVKVVIIG
     QDPYHGPQQA QGLSFSVPDN LPAPPSLQNI LKELAEDIGS RSHHDLTSWA QQGVLLLNAC
     LTVPEHQANG HAGLIWEPFT DAVIKVVNQK ETPVVFILWG GYARKKKSLI DNPIHHIIES
     PHPSPLSAYR GFFGSRPFSR TNHFLEEEGI NEIDWLN
//
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