ID MALR_STRR6 Reviewed; 328 AA.
AC P0A4T2; Q08511;
DT 15-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT 23-JAN-2007, sequence version 2.
DT 29-MAY-2013, entry version 62.
DE RecName: Full=HTH-type transcriptional regulator MalR;
DE AltName: Full=Maltose operon transcriptional repressor;
GN Name=malR; OrderedLocusNames=spr1922;
OS Streptococcus pneumoniae (strain ATCC BAA-255 / R6).
OC Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC Streptococcus.
OX NCBI_TaxID=171101;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND PROTEIN SEQUENCE OF 2-3; 5-6
RP AND 8-11.
RX PubMed=8244973;
RA Puyet A., Ibanez A.M., Espinosa M.;
RT "Characterization of the Streptococcus pneumoniae maltosaccharide
RT regulator MalR, a member of the LacI-GalR family of repressors
RT displaying distinctive genetic features.";
RL J. Biol. Chem. 268:25402-25408(1993).
RN [2]
RP SEQUENCE REVISION TO 43-56.
RA Puyet A.;
RL Submitted (DEC-1997) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC BAA-255 / R6;
RX PubMed=11544234; DOI=10.1128/JB.183.19.5709-5717.2001;
RA Hoskins J., Alborn W.E. Jr., Arnold J., Blaszczak L.C., Burgett S.,
RA DeHoff B.S., Estrem S.T., Fritz L., Fu D.-J., Fuller W., Geringer C.,
RA Gilmour R., Glass J.S., Khoja H., Kraft A.R., Lagace R.E.,
RA LeBlanc D.J., Lee L.N., Lefkowitz E.J., Lu J., Matsushima P.,
RA McAhren S.M., McHenney M., McLeaster K., Mundy C.W., Nicas T.I.,
RA Norris F.H., O'Gara M., Peery R.B., Robertson G.T., Rockey P.,
RA Sun P.-M., Winkler M.E., Yang Y., Young-Bellido M., Zhao G.,
RA Zook C.A., Baltz R.H., Jaskunas S.R., Rosteck P.R. Jr., Skatrud P.L.,
RA Glass J.I.;
RT "Genome of the bacterium Streptococcus pneumoniae strain R6.";
RL J. Bacteriol. 183:5709-5717(2001).
CC -!- FUNCTION: Transcriptional repressor of the maltosaccharide
CC utilization operons malxCD and malMP.
CC -!- SIMILARITY: Contains 1 HTH lacI-type DNA-binding domain.
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DR EMBL; L21856; AAB88011.1; -; Unassigned_DNA.
DR EMBL; AE007317; AAL00724.1; -; Genomic_DNA.
DR PIR; G98111; G98111.
DR RefSeq; NP_359513.1; NC_003098.1.
DR ProteinModelPortal; P0A4T2; -.
DR STRING; 171101.spr1922; -.
DR EnsemblBacteria; AAL00724; AAL00724; spr1922.
DR GeneID; 934853; -.
DR KEGG; spr:spr1922; -.
DR PATRIC; 19704016; VBIStrPne107296_2071.
DR eggNOG; COG1609; -.
DR HOGENOM; HOG000220180; -.
DR KO; K02529; -.
DR OMA; AYVDINT; -.
DR ProtClustDB; CLSK884199; -.
DR BioCyc; SPNE171101:GJC8-1988-MONOMER; -.
DR GO; GO:0005622; C:intracellular; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003700; F:sequence-specific DNA binding transcription factor activity; IEA:InterPro.
DR GO; GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
DR Gene3D; 1.10.260.40; -; 1.
DR InterPro; IPR010982; Lambda_DNA-bd_dom.
DR InterPro; IPR001761; Peripla_BP/Lac1_sug-bd_dom.
DR InterPro; IPR000843; Tscrpt_reg_HTH_LacI.
DR Pfam; PF00356; LacI; 1.
DR Pfam; PF00532; Peripla_BP_1; 1.
DR PRINTS; PR00036; HTHLACI.
DR SMART; SM00354; HTH_LACI; 1.
DR SUPFAM; SSF47413; Lambda_like_DNA; 1.
DR PROSITE; PS00356; HTH_LACI_1; 1.
DR PROSITE; PS50932; HTH_LACI_2; 1.
PE 1: Evidence at protein level;
KW Complete proteome; Direct protein sequencing; DNA-binding;
KW Reference proteome; Repressor; Transcription;
KW Transcription regulation.
FT INIT_MET 1 1 Removed.
FT CHAIN 2 328 HTH-type transcriptional regulator MalR.
FT /FTId=PRO_0000107972.
FT DOMAIN 2 57 HTH lacI-type.
FT DNA_BIND 5 24 H-T-H motif (Potential).
FT REGION 173 218 Inducer binding (Potential).
FT REGION 282 291 Dimerization (Potential).
SQ SEQUENCE 328 AA; 37044 MW; 0D8026C93ECB232D CRC64;
MPVTIKDVAK AAGVSPSTVT RVIQNKSTIS DETKKRVRKA MKELNYHPNL NARSLVSSYT
QVIGLVLPDD SDAFYQNPFF PSVLRGISQV ASENHYAIQI ATGKDEKERL NAISQMVYGK
RVDGLIFLYA QEEDPLVKLV AEEQFPFLIL GKSLSPFIPL VDNDNVQAGF DATEYFIKKG
CKRIAFIGGS KKLFVTKDRL TGYEQALKHY KLTTDNNRIY FADEFLEEKG YKFSKRLFKH
DPQIDAIITT DSLLAEGVCN YIAKHQLDVP VLSFDSVNPK LNLAAYVDIN SLELGRVSLE
TILQIINDNK NNKQICYRQL IAHKIIEK
//
