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Database: UniProt
Entry: P0A4T2
LinkDB: P0A4T2
Original site: P0A4T2 
ID   MALR_STRR6              Reviewed;         328 AA.
AC   P0A4T2; Q08511;
DT   15-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 2.
DT   19-FEB-2014, entry version 65.
DE   RecName: Full=HTH-type transcriptional regulator MalR;
DE   AltName: Full=Maltose operon transcriptional repressor;
GN   Name=malR; OrderedLocusNames=spr1922;
OS   Streptococcus pneumoniae (strain ATCC BAA-255 / R6).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC   Streptococcus.
OX   NCBI_TaxID=171101;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND PROTEIN SEQUENCE OF 2-3; 5-6
RP   AND 8-11.
RX   PubMed=8244973;
RA   Puyet A., Ibanez A.M., Espinosa M.;
RT   "Characterization of the Streptococcus pneumoniae maltosaccharide
RT   regulator MalR, a member of the LacI-GalR family of repressors
RT   displaying distinctive genetic features.";
RL   J. Biol. Chem. 268:25402-25408(1993).
RN   [2]
RP   SEQUENCE REVISION TO 43-56.
RA   Puyet A.;
RL   Submitted (DEC-1997) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-255 / R6;
RX   PubMed=11544234; DOI=10.1128/JB.183.19.5709-5717.2001;
RA   Hoskins J., Alborn W.E. Jr., Arnold J., Blaszczak L.C., Burgett S.,
RA   DeHoff B.S., Estrem S.T., Fritz L., Fu D.-J., Fuller W., Geringer C.,
RA   Gilmour R., Glass J.S., Khoja H., Kraft A.R., Lagace R.E.,
RA   LeBlanc D.J., Lee L.N., Lefkowitz E.J., Lu J., Matsushima P.,
RA   McAhren S.M., McHenney M., McLeaster K., Mundy C.W., Nicas T.I.,
RA   Norris F.H., O'Gara M., Peery R.B., Robertson G.T., Rockey P.,
RA   Sun P.-M., Winkler M.E., Yang Y., Young-Bellido M., Zhao G.,
RA   Zook C.A., Baltz R.H., Jaskunas S.R., Rosteck P.R. Jr., Skatrud P.L.,
RA   Glass J.I.;
RT   "Genome of the bacterium Streptococcus pneumoniae strain R6.";
RL   J. Bacteriol. 183:5709-5717(2001).
CC   -!- FUNCTION: Transcriptional repressor of the maltosaccharide
CC       utilization operons malxCD and malMP.
CC   -!- SIMILARITY: Contains 1 HTH lacI-type DNA-binding domain.
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DR   EMBL; L21856; AAB88011.1; -; Unassigned_DNA.
DR   EMBL; AE007317; AAL00724.1; -; Genomic_DNA.
DR   PIR; G98111; G98111.
DR   RefSeq; NP_359513.1; NC_003098.1.
DR   ProteinModelPortal; P0A4T2; -.
DR   STRING; 171101.spr1922; -.
DR   EnsemblBacteria; AAL00724; AAL00724; spr1922.
DR   GeneID; 934853; -.
DR   KEGG; spr:spr1922; -.
DR   PATRIC; 19704016; VBIStrPne107296_2071.
DR   eggNOG; COG1609; -.
DR   HOGENOM; HOG000220180; -.
DR   KO; K02529; -.
DR   OMA; TENMEIS; -.
DR   OrthoDB; EOG6SJJMM; -.
DR   ProtClustDB; CLSK884199; -.
DR   BioCyc; SPNE171101:GJC8-1988-MONOMER; -.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003700; F:sequence-specific DNA binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.260.40; -; 1.
DR   InterPro; IPR010982; Lambda_DNA-bd_dom.
DR   InterPro; IPR001761; Peripla_BP/Lac1_sug-bd_dom.
DR   InterPro; IPR028082; Peripla_BP_I.
DR   InterPro; IPR000843; Tscrpt_reg_HTH_LacI.
DR   Pfam; PF00356; LacI; 1.
DR   Pfam; PF00532; Peripla_BP_1; 1.
DR   PRINTS; PR00036; HTHLACI.
DR   SMART; SM00354; HTH_LACI; 1.
DR   SUPFAM; SSF47413; SSF47413; 1.
DR   SUPFAM; SSF53822; SSF53822; 1.
DR   PROSITE; PS00356; HTH_LACI_1; 1.
DR   PROSITE; PS50932; HTH_LACI_2; 1.
PE   1: Evidence at protein level;
KW   Complete proteome; Direct protein sequencing; DNA-binding;
KW   Reference proteome; Repressor; Transcription;
KW   Transcription regulation.
FT   INIT_MET      1      1       Removed.
FT   CHAIN         2    328       HTH-type transcriptional regulator MalR.
FT                                /FTId=PRO_0000107972.
FT   DOMAIN        2     57       HTH lacI-type.
FT   DNA_BIND      5     24       H-T-H motif (Potential).
FT   REGION      173    218       Inducer binding (Potential).
FT   REGION      282    291       Dimerization (Potential).
SQ   SEQUENCE   328 AA;  37044 MW;  0D8026C93ECB232D CRC64;
     MPVTIKDVAK AAGVSPSTVT RVIQNKSTIS DETKKRVRKA MKELNYHPNL NARSLVSSYT
     QVIGLVLPDD SDAFYQNPFF PSVLRGISQV ASENHYAIQI ATGKDEKERL NAISQMVYGK
     RVDGLIFLYA QEEDPLVKLV AEEQFPFLIL GKSLSPFIPL VDNDNVQAGF DATEYFIKKG
     CKRIAFIGGS KKLFVTKDRL TGYEQALKHY KLTTDNNRIY FADEFLEEKG YKFSKRLFKH
     DPQIDAIITT DSLLAEGVCN YIAKHQLDVP VLSFDSVNPK LNLAAYVDIN SLELGRVSLE
     TILQIINDNK NNKQICYRQL IAHKIIEK
//
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