ID Y1273_MYCTU Reviewed; 582 AA.
AC P0A4W4; L0T8W5; Q11046;
DT 15-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT 15-MAR-2005, sequence version 1.
DT 01-MAY-2013, entry version 64.
DE RecName: Full=Uncharacterized ABC transporter ATP-binding protein Rv1273c/MT1311;
GN OrderedLocusNames=Rv1273c, MT1311; ORFNames=MTCY50.09;
OS Mycobacterium tuberculosis.
OC Bacteria; Actinobacteria; Actinobacteridae; Actinomycetales;
OC Corynebacterineae; Mycobacteriaceae; Mycobacterium;
OC Mycobacterium tuberculosis complex.
OX NCBI_TaxID=1773;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 25618 / H37Rv;
RX PubMed=9634230; DOI=10.1038/31159;
RA Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M.,
RA Harris D.E., Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III,
RA Tekaia F., Badcock K., Basham D., Brown D., Chillingworth T.,
RA Connor R., Davies R.M., Devlin K., Feltwell T., Gentles S., Hamlin N.,
RA Holroyd S., Hornsby T., Jagels K., Krogh A., McLean J., Moule S.,
RA Murphy L.D., Oliver S., Osborne J., Quail M.A., Rajandream M.A.,
RA Rogers J., Rutter S., Seeger K., Skelton S., Squares S., Squares R.,
RA Sulston J.E., Taylor K., Whitehead S., Barrell B.G.;
RT "Deciphering the biology of Mycobacterium tuberculosis from the
RT complete genome sequence.";
RL Nature 393:537-544(1998).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CDC 1551 / Oshkosh;
RX PubMed=12218036; DOI=10.1128/JB.184.19.5479-5490.2002;
RA Fleischmann R.D., Alland D., Eisen J.A., Carpenter L., White O.,
RA Peterson J.D., DeBoy R.T., Dodson R.J., Gwinn M.L., Haft D.H.,
RA Hickey E.K., Kolonay J.F., Nelson W.C., Umayam L.A., Ermolaeva M.D.,
RA Salzberg S.L., Delcher A., Utterback T.R., Weidman J.F., Khouri H.M.,
RA Gill J., Mikula A., Bishai W., Jacobs W.R. Jr., Venter J.C.,
RA Fraser C.M.;
RT "Whole-genome comparison of Mycobacterium tuberculosis clinical and
RT laboratory strains.";
RL J. Bacteriol. 184:5479-5490(2002).
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein
CC (Potential).
CC -!- SIMILARITY: Belongs to the ABC transporter superfamily.
CC -!- SIMILARITY: Contains 1 ABC transmembrane type-1 domain.
CC -!- SIMILARITY: Contains 1 ABC transporter domain.
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DR EMBL; BX842576; CAB00907.1; -; Genomic_DNA.
DR EMBL; AE000516; AAK45571.1; -; Genomic_DNA.
DR EMBL; AL123456; CCP44029.1; -; Genomic_DNA.
DR PIR; A70755; A70755.
DR RefSeq; NP_215789.1; NC_000962.3.
DR RefSeq; NP_335757.1; NC_002755.2.
DR RefSeq; YP_006514648.1; NC_018143.1.
DR ProteinModelPortal; P0A4W4; -.
DR SMR; P0A4W4; 6-572.
DR STRING; 83332.Rv1273c; -.
DR EnsemblBacteria; AAK45571; AAK45571; MT1311.
DR GeneID; 13319852; -.
DR GeneID; 887025; -.
DR GeneID; 924759; -.
DR KEGG; mtc:MT1311; -.
DR KEGG; mtu:Rv1273c; -.
DR KEGG; mtv:RVBD_1273c; -.
DR PATRIC; 18124648; VBIMycTub22151_1443.
DR TubercuList; Rv1273c; -.
DR eggNOG; COG1132; -.
DR KO; K06147; -.
DR OMA; RATVCAE; -.
DR ProtClustDB; CLSK791069; -.
DR GO; GO:0005618; C:cell wall; IDA:MTBBASE.
DR GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0042626; F:ATPase activity, coupled to transmembrane movement of substances; IEA:InterPro.
DR GO; GO:0006200; P:ATP catabolic process; IEA:GOC.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR003439; ABC_transporter-like.
DR InterPro; IPR017871; ABC_transporter_CS.
DR InterPro; IPR017940; ABC_transporter_type1.
DR InterPro; IPR001140; ABC_transptr_TM_dom.
DR InterPro; IPR011527; ABC_transptrTM_dom_typ1.
DR Pfam; PF00664; ABC_membrane; 1.
DR Pfam; PF00005; ABC_tran; 1.
DR SMART; SM00382; AAA; 1.
DR SUPFAM; SSF90123; ABC_TM_1; 1.
DR PROSITE; PS50929; ABC_TM1F; 1.
DR PROSITE; PS00211; ABC_TRANSPORTER_1; 2.
DR PROSITE; PS50893; ABC_TRANSPORTER_2; 1.
PE 3: Inferred from homology;
KW ATP-binding; Cell membrane; Complete proteome; Membrane;
KW Nucleotide-binding; Reference proteome; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1 582 Uncharacterized ABC transporter ATP-
FT binding protein Rv1273c/MT1311.
FT /FTId=PRO_0000093264.
FT TRANSMEM 17 37 Helical; (Potential).
FT TRANSMEM 57 77 Helical; (Potential).
FT TRANSMEM 131 151 Helical; (Potential).
FT TRANSMEM 156 176 Helical; (Potential).
FT TRANSMEM 239 259 Helical; (Potential).
FT TRANSMEM 271 291 Helical; (Potential).
FT DOMAIN 17 300 ABC transmembrane type-1.
FT DOMAIN 335 571 ABC transporter.
FT NP_BIND 369 376 ATP (Potential).
FT CONFLICT 40 40 A -> E (in Ref. 2; AAK45571).
SQ SEQUENCE 582 AA; 62116 MW; B9002E187776691F CRC64;
MLLALLRQHI RPYRRLVAML MMLQLVSTLA SLYLPTVNAA IVDDGVAKGD TATIVRLGAV
MLGVTGLQVL CAIGAVYLGS RTGAGFGRDL RSAMFEHIIT FSERETARFG APTLLTRSTN
DVRQILFLVQ MTATVLVTAP IMCVGGIIMA IHQEAALTWL LLVSVPILAV ANYWIISHML
PLFRRMQSLI DGINRVMRDQ LSGVRVVRAF TREGYERDKF AQANTALSNA ALSAGNWQAL
MLPVTTLTIN ASSVALIWFG GLRIDSGQMQ VGSLIAFLSY FAQILMAVLM ATMTLAVLPR
ASVCAERITE VLSTPAALGN PDNPKFPTDG VTGVVRLAGA TFTYPGADCP VLQDISLTAR
PGTTTAIVGS TGSGKSTLVS LICRLYDVTA GAVLVDGIDV REYHTERLWS AIGLVPQRSY
LFSGTVADNL RYGGGPDQVV TEQEMWEALR VAAADGFVQT DGLQTRVAQG GVNFSGGQRQ
RLAIARAVIR RPAIYVFDDA FSALDVHTDA KVHASLRQVS GDATIIVVTQ RISNAAQADQ
VIVVDNGKIV GTGTHETLLA DCPTYAEFAA SQSLSATVGG VG
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