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Database: UniProt
Entry: P0A638
LinkDB: P0A638
Original site: P0A638 
ID   UBIE_MYCTU              Reviewed;         234 AA.
AC   P0A638; L0T453; O06424;
DT   15-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT   15-MAR-2005, sequence version 1.
DT   19-MAR-2014, entry version 63.
DE   RecName: Full=Demethylmenaquinone methyltransferase;
DE            EC=2.1.1.163;
DE   AltName: Full=Menaquinone biosynthesis C-methyltransferase UbiE;
GN   Name=ubiE; Synonyms=menH; OrderedLocusNames=Rv0558, MT0584;
GN   ORFNames=MTCY25D10.37;
OS   Mycobacterium tuberculosis.
OC   Bacteria; Actinobacteria; Actinobacteridae; Actinomycetales;
OC   Corynebacterineae; Mycobacteriaceae; Mycobacterium;
OC   Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=1773;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=9634230; DOI=10.1038/31159;
RA   Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M.,
RA   Harris D.E., Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III,
RA   Tekaia F., Badcock K., Basham D., Brown D., Chillingworth T.,
RA   Connor R., Davies R.M., Devlin K., Feltwell T., Gentles S., Hamlin N.,
RA   Holroyd S., Hornsby T., Jagels K., Krogh A., McLean J., Moule S.,
RA   Murphy L.D., Oliver S., Osborne J., Quail M.A., Rajandream M.A.,
RA   Rogers J., Rutter S., Seeger K., Skelton S., Squares S., Squares R.,
RA   Sulston J.E., Taylor K., Whitehead S., Barrell B.G.;
RT   "Deciphering the biology of Mycobacterium tuberculosis from the
RT   complete genome sequence.";
RL   Nature 393:537-544(1998).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CDC 1551 / Oshkosh;
RX   PubMed=12218036; DOI=10.1128/JB.184.19.5479-5490.2002;
RA   Fleischmann R.D., Alland D., Eisen J.A., Carpenter L., White O.,
RA   Peterson J.D., DeBoy R.T., Dodson R.J., Gwinn M.L., Haft D.H.,
RA   Hickey E.K., Kolonay J.F., Nelson W.C., Umayam L.A., Ermolaeva M.D.,
RA   Salzberg S.L., Delcher A., Utterback T.R., Weidman J.F., Khouri H.M.,
RA   Gill J., Mikula A., Bishai W., Jacobs W.R. Jr., Venter J.C.,
RA   Fraser C.M.;
RT   "Whole-genome comparison of Mycobacterium tuberculosis clinical and
RT   laboratory strains.";
RL   J. Bacteriol. 184:5479-5490(2002).
RN   [3]
RP   IDENTIFICATION AS A DRUG TARGET [LARGE SCALE ANALYSIS].
RX   PubMed=19099550; DOI=10.1186/1752-0509-2-109;
RA   Raman K., Yeturu K., Chandra N.;
RT   "targetTB: a target identification pipeline for Mycobacterium
RT   tuberculosis through an interactome, reactome and genome-scale
RT   structural analysis.";
RL   BMC Syst. Biol. 2:109-109(2008).
CC   -!- FUNCTION: Methyltransferase required for the conversion of
CC       demethylmenaquinone (DMKH2) to menaquinone (MKH2) (By similarity).
CC   -!- CATALYTIC ACTIVITY: A demethylmenaquinone + S-adenosyl-L-
CC       methionine = a menaquinol + S-adenosyl-L-homocysteine.
CC   -!- PATHWAY: Cofactor biosynthesis; menaquinone biosynthesis;
CC       menaquinone-2 from chorismate: step 8/8.
CC   -!- MISCELLANEOUS: Was identified as a high-confidence drug target.
CC   -!- SIMILARITY: Belongs to the class I-like SAM-binding
CC       methyltransferase superfamily. UbiE family.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAK44807.1; Type=Erroneous initiation;
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DR   EMBL; AE000516; AAK44807.1; ALT_INIT; Genomic_DNA.
DR   EMBL; AL123456; CCP43296.1; -; Genomic_DNA.
DR   PIR; A70549; A70549.
DR   RefSeq; NP_334993.2; NC_002755.2.
DR   RefSeq; YP_006513891.1; NC_018143.2.
DR   RefSeq; YP_177738.1; NC_000962.3.
DR   ProteinModelPortal; P0A638; -.
DR   SMR; P0A638; 13-213.
DR   STRING; 83332.Rv0558; -.
DR   PRIDE; P0A638; -.
DR   EnsemblBacteria; AAK44807; AAK44807; MT0584.
DR   EnsemblBacteria; CCP43296; CCP43296; Rv0558.
DR   GeneID; 13318432; -.
DR   GeneID; 887591; -.
DR   GeneID; 924958; -.
DR   KEGG; mtc:MT0584; -.
DR   KEGG; mtu:Rv0558; -.
DR   KEGG; mtv:RVBD_0558; -.
DR   PATRIC; 18122984; VBIMycTub22151_0626.
DR   TubercuList; Rv0558; -.
DR   eggNOG; COG2226; -.
DR   HOGENOM; HOG000249464; -.
DR   KO; K03183; -.
DR   OMA; IWKRFTI; -.
DR   OrthoDB; EOG6M6JSB; -.
DR   ProtClustDB; PRK00216; -.
DR   BioCyc; MTBRV:RV0558-MONOMER; -.
DR   UniPathway; UPA00079; UER00169.
DR   GO; GO:0005886; C:plasma membrane; IDA:MTBBASE.
DR   GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
DR   GO; GO:0040007; P:growth; IMP:MTBBASE.
DR   GO; GO:0009234; P:menaquinone biosynthetic process; IEA:UniProtKB-UniPathway.
DR   HAMAP; MF_01813; UbiE_methyltran; 1.
DR   InterPro; IPR004033; UbiE/COQ5_MeTrFase.
DR   InterPro; IPR023576; UbiE/COQ5_MeTrFase_CS.
DR   Pfam; PF01209; Ubie_methyltran; 1.
DR   TIGRFAMs; TIGR01934; MenG_MenH_UbiE; 1.
DR   PROSITE; PS51608; SAM_MT_UBIE; 1.
DR   PROSITE; PS01183; UBIE_1; 1.
DR   PROSITE; PS01184; UBIE_2; 1.
PE   3: Inferred from homology;
KW   Complete proteome; Menaquinone biosynthesis; Methyltransferase;
KW   Reference proteome; S-adenosyl-L-methionine; Transferase.
FT   CHAIN         1    234       Demethylmenaquinone methyltransferase.
FT                                /FTId=PRO_0000193297.
SQ   SEQUENCE   234 AA;  25299 MW;  220DE28AD89F2ABD CRC64;
     MSRAALDKDP RDVASMFDGV ARKYDLTNTV LSLGQDRYWR RATRSALRIG PGQKVLDLAA
     GTAVSTVELT KSGAWCVAAD FSVGMLAAGA ARKVPKVAGD ATRLPFGDDV FDAVTISFGL
     RNVANQQAAL REMARVTRPG GRLLVCEFST PTNALFATAY KEYLMRALPR VARAVSSNPE
     AYEYLAESIR AWPDQAVLAH QISRAGWSGV RWRNLTGGIV ALHAGYKPGK QTPQ
//
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