ID UBIE_MYCTU Reviewed; 234 AA.
AC P0A638; L0T453; O06424;
DT 15-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT 15-MAR-2005, sequence version 1.
DT 01-MAY-2013, entry version 55.
DE RecName: Full=Demethylmenaquinone methyltransferase;
DE EC=2.1.1.163;
DE AltName: Full=Menaquinone biosynthesis methyltransferase ubiE;
GN Name=ubiE; Synonyms=menH; OrderedLocusNames=Rv0558, MT0584;
GN ORFNames=MTCY25D10.37;
OS Mycobacterium tuberculosis.
OC Bacteria; Actinobacteria; Actinobacteridae; Actinomycetales;
OC Corynebacterineae; Mycobacteriaceae; Mycobacterium;
OC Mycobacterium tuberculosis complex.
OX NCBI_TaxID=1773;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 25618 / H37Rv;
RX PubMed=9634230; DOI=10.1038/31159;
RA Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M.,
RA Harris D.E., Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III,
RA Tekaia F., Badcock K., Basham D., Brown D., Chillingworth T.,
RA Connor R., Davies R.M., Devlin K., Feltwell T., Gentles S., Hamlin N.,
RA Holroyd S., Hornsby T., Jagels K., Krogh A., McLean J., Moule S.,
RA Murphy L.D., Oliver S., Osborne J., Quail M.A., Rajandream M.A.,
RA Rogers J., Rutter S., Seeger K., Skelton S., Squares S., Squares R.,
RA Sulston J.E., Taylor K., Whitehead S., Barrell B.G.;
RT "Deciphering the biology of Mycobacterium tuberculosis from the
RT complete genome sequence.";
RL Nature 393:537-544(1998).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CDC 1551 / Oshkosh;
RX PubMed=12218036; DOI=10.1128/JB.184.19.5479-5490.2002;
RA Fleischmann R.D., Alland D., Eisen J.A., Carpenter L., White O.,
RA Peterson J.D., DeBoy R.T., Dodson R.J., Gwinn M.L., Haft D.H.,
RA Hickey E.K., Kolonay J.F., Nelson W.C., Umayam L.A., Ermolaeva M.D.,
RA Salzberg S.L., Delcher A., Utterback T.R., Weidman J.F., Khouri H.M.,
RA Gill J., Mikula A., Bishai W., Jacobs W.R. Jr., Venter J.C.,
RA Fraser C.M.;
RT "Whole-genome comparison of Mycobacterium tuberculosis clinical and
RT laboratory strains.";
RL J. Bacteriol. 184:5479-5490(2002).
RN [3]
RP IDENTIFICATION AS A DRUG TARGET [LARGE SCALE ANALYSIS].
RX PubMed=19099550; DOI=10.1186/1752-0509-2-109;
RA Raman K., Yeturu K., Chandra N.;
RT "targetTB: a target identification pipeline for Mycobacterium
RT tuberculosis through an interactome, reactome and genome-scale
RT structural analysis.";
RL BMC Syst. Biol. 2:109-109(2008).
CC -!- FUNCTION: Methyltransferase required for the conversion of
CC demethylmenaquinone (DMKH2) to menaquinone (MKH2) (By similarity).
CC -!- CATALYTIC ACTIVITY: A demethylmenaquinone + S-adenosyl-L-
CC methionine = a menaquinol + S-adenosyl-L-homocysteine.
CC -!- PATHWAY: Cofactor biosynthesis; menaquinone biosynthesis;
CC menaquinone-2 from chorismate: step 8/8.
CC -!- MISCELLANEOUS: Was identified as a high-confidence drug target.
CC -!- SIMILARITY: Belongs to the methyltransferase superfamily. UbiE
CC family.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAK44807.1; Type=Erroneous initiation;
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DR EMBL; BX842573; CAE55299.1; -; Genomic_DNA.
DR EMBL; AE000516; AAK44807.1; ALT_INIT; Genomic_DNA.
DR EMBL; AL123456; CCP43296.1; -; Genomic_DNA.
DR PIR; A70549; A70549.
DR RefSeq; NP_334993.2; NC_002755.2.
DR RefSeq; YP_006513891.1; NC_018143.1.
DR RefSeq; YP_177738.1; NC_000962.3.
DR ProteinModelPortal; P0A638; -.
DR SMR; P0A638; 53-160.
DR STRING; 83332.Rv0558; -.
DR PRIDE; P0A638; -.
DR EnsemblBacteria; AAK44807; AAK44807; MT0584.
DR GeneID; 13318432; -.
DR GeneID; 887591; -.
DR GeneID; 924958; -.
DR KEGG; mtc:MT0584; -.
DR KEGG; mtu:Rv0558; -.
DR KEGG; mtv:RVBD_0558; -.
DR PATRIC; 18122984; VBIMycTub22151_0626.
DR TubercuList; Rv0558; -.
DR eggNOG; COG2226; -.
DR HOGENOM; HOG000249464; -.
DR KO; K03183; -.
DR OMA; PYQYLVE; -.
DR ProtClustDB; PRK00216; -.
DR UniPathway; UPA00079; UER00169.
DR GO; GO:0005886; C:plasma membrane; IDA:MTBBASE.
DR GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
DR GO; GO:0040007; P:growth; IMP:MTBBASE.
DR GO; GO:0009234; P:menaquinone biosynthetic process; IEA:UniProtKB-UniPathway.
DR HAMAP; MF_01813; UbiE_methyltran; 1; -.
DR InterPro; IPR004033; UbiE/COQ5_MeTrFase.
DR InterPro; IPR023576; UbiE/COQ5_MeTrFase_CS.
DR PANTHER; PTHR10108:SF24; PTHR10108:SF24; 1.
DR Pfam; PF01209; Ubie_methyltran; 1.
DR TIGRFAMs; TIGR01934; MenG_MenH_UbiE; 1.
DR PROSITE; PS01183; UBIE_1; 1.
DR PROSITE; PS01184; UBIE_2; 1.
PE 3: Inferred from homology;
KW Complete proteome; Menaquinone biosynthesis; Methyltransferase;
KW Reference proteome; Transferase.
FT CHAIN 1 234 Demethylmenaquinone methyltransferase.
FT /FTId=PRO_0000193297.
SQ SEQUENCE 234 AA; 25299 MW; 220DE28AD89F2ABD CRC64;
MSRAALDKDP RDVASMFDGV ARKYDLTNTV LSLGQDRYWR RATRSALRIG PGQKVLDLAA
GTAVSTVELT KSGAWCVAAD FSVGMLAAGA ARKVPKVAGD ATRLPFGDDV FDAVTISFGL
RNVANQQAAL REMARVTRPG GRLLVCEFST PTNALFATAY KEYLMRALPR VARAVSSNPE
AYEYLAESIR AWPDQAVLAH QISRAGWSGV RWRNLTGGIV ALHAGYKPGK QTPQ
//
