ID CPXR_ECO57 Reviewed; 232 AA.
AC P0AE89; P16244; P76777;
DT 06-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT 06-DEC-2005, sequence version 1.
DT 01-MAY-2013, entry version 58.
DE RecName: Full=Transcriptional regulatory protein CpxR;
GN Name=cpxR; OrderedLocusNames=Z5457, ECs4838;
OS Escherichia coli O157:H7.
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacteriales;
OC Enterobacteriaceae; Escherichia.
OX NCBI_TaxID=83334;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=O157:H7 / EDL933 / ATCC 700927 / EHEC;
RX PubMed=11206551; DOI=10.1038/35054089;
RA Perna N.T., Plunkett G. III, Burland V., Mau B., Glasner J.D.,
RA Rose D.J., Mayhew G.F., Evans P.S., Gregor J., Kirkpatrick H.A.,
RA Posfai G., Hackett J., Klink S., Boutin A., Shao Y., Miller L.,
RA Grotbeck E.J., Davis N.W., Lim A., Dimalanta E.T., Potamousis K.,
RA Apodaca J., Anantharaman T.S., Lin J., Yen G., Schwartz D.C.,
RA Welch R.A., Blattner F.R.;
RT "Genome sequence of enterohaemorrhagic Escherichia coli O157:H7.";
RL Nature 409:529-533(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=O157:H7 / Sakai / RIMD 0509952 / EHEC;
RX PubMed=11258796; DOI=10.1093/dnares/8.1.11;
RA Hayashi T., Makino K., Ohnishi M., Kurokawa K., Ishii K., Yokoyama K.,
RA Han C.-G., Ohtsubo E., Nakayama K., Murata T., Tanaka M., Tobe T.,
RA Iida T., Takami H., Honda T., Sasakawa C., Ogasawara N., Yasunaga T.,
RA Kuhara S., Shiba T., Hattori M., Shinagawa H.;
RT "Complete genome sequence of enterohemorrhagic Escherichia coli
RT O157:H7 and genomic comparison with a laboratory strain K-12.";
RL DNA Res. 8:11-22(2001).
CC -!- FUNCTION: Member of the two-component regulatory system CpxA/CpxR.
CC This system combats a variety of extracytoplasmic protein-mediated
CC toxicities. It performs this function by increasing the synthesis
CC of the periplasmic protease, DegP as well as that of CpxP protein
CC (By similarity).
CC -!- SUBCELLULAR LOCATION: Cytoplasm (Probable).
CC -!- PTM: Phosphorylated by CpxA (Potential).
CC -!- SIMILARITY: Contains 1 response regulatory domain.
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DR EMBL; AE005174; AAG59106.1; -; Genomic_DNA.
DR EMBL; BA000007; BAB38261.1; -; Genomic_DNA.
DR PIR; F86080; F86080.
DR PIR; F91233; F91233.
DR RefSeq; NP_290542.1; NC_002655.2.
DR RefSeq; NP_312865.1; NC_002695.1.
DR ProteinModelPortal; P0AE89; -.
DR SMR; P0AE89; 3-228.
DR STRING; 155864.Z5457; -.
DR EnsemblBacteria; AAG59106; AAG59106; Z5457.
DR EnsemblBacteria; BAB38261; BAB38261; BAB38261.
DR GeneID; 915041; -.
DR GeneID; 960233; -.
DR KEGG; ece:Z5457; -.
DR KEGG; ecs:ECs4838; -.
DR PATRIC; 18359335; VBIEscCol44059_4817.
DR eggNOG; COG0745; -.
DR HOGENOM; HOG000034819; -.
DR KO; K07662; -.
DR OMA; YQTPVIM; -.
DR ProtClustDB; PRK10955; -.
DR BioCyc; ECOL386585:GJFA-4827-MONOMER; -.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0000156; F:phosphorelay response regulator activity; IEA:InterPro.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:GOC.
DR GO; GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.
DR GO; GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
DR Gene3D; 1.10.10.10; -; 1.
DR InterPro; IPR011006; CheY-like_superfamily.
DR InterPro; IPR001867; Sig_transdc_resp-reg_C.
DR InterPro; IPR001789; Sig_transdc_resp-reg_receiver.
DR InterPro; IPR011991; WHTH_DNA-bd_dom.
DR Pfam; PF00072; Response_reg; 1.
DR Pfam; PF00486; Trans_reg_C; 1.
DR SMART; SM00448; REC; 1.
DR SMART; SM00862; Trans_reg_C; 1.
DR SUPFAM; SSF52172; CheY_like; 1.
DR PROSITE; PS50110; RESPONSE_REGULATORY; 1.
PE 3: Inferred from homology;
KW Complete proteome; Cytoplasm; DNA-binding; Phosphoprotein;
KW Transcription; Transcription regulation;
KW Two-component regulatory system.
FT CHAIN 1 232 Transcriptional regulatory protein CpxR.
FT /FTId=PRO_0000081079.
FT DOMAIN 1 115 Response regulatory.
FT MOD_RES 51 51 4-aspartylphosphate (By similarity).
SQ SEQUENCE 232 AA; 26312 MW; 667FC2B246082F46 CRC64;
MNKILLVDDD RELTSLLKEL LEMEGFNVIV AHDGEQALDL LDDSIDLLLL DVMMPKKNGI
DTLKALRQTH QTPVIMLTAR GSELDRVLGL ELGADDYLPK PFNDRELVAR IRAILRRSHW
SEQQQNNDNG SPTLEVDALV LNPGRQEASF DGQTLELTGT EFTLLYLLAQ HLGQVVSREH
LSQEVLGKRL TPFDRAIDMH ISNLRRKLPD RKDGHPWFKT LRGRGYLMVS AS
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