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Database: UniProt
Entry: P0AE89
LinkDB: P0AE89
Original site: P0AE89 
ID   CPXR_ECO57              Reviewed;         232 AA.
AC   P0AE89; P16244; P76777;
DT   06-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT   06-DEC-2005, sequence version 1.
DT   14-MAY-2014, entry version 64.
DE   RecName: Full=Transcriptional regulatory protein CpxR;
GN   Name=cpxR; OrderedLocusNames=Z5457, ECs4838;
OS   Escherichia coli O157:H7.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacteriales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=83334;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=O157:H7 / EDL933 / ATCC 700927 / EHEC;
RX   PubMed=11206551; DOI=10.1038/35054089;
RA   Perna N.T., Plunkett G. III, Burland V., Mau B., Glasner J.D.,
RA   Rose D.J., Mayhew G.F., Evans P.S., Gregor J., Kirkpatrick H.A.,
RA   Posfai G., Hackett J., Klink S., Boutin A., Shao Y., Miller L.,
RA   Grotbeck E.J., Davis N.W., Lim A., Dimalanta E.T., Potamousis K.,
RA   Apodaca J., Anantharaman T.S., Lin J., Yen G., Schwartz D.C.,
RA   Welch R.A., Blattner F.R.;
RT   "Genome sequence of enterohaemorrhagic Escherichia coli O157:H7.";
RL   Nature 409:529-533(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=O157:H7 / Sakai / RIMD 0509952 / EHEC;
RX   PubMed=11258796; DOI=10.1093/dnares/8.1.11;
RA   Hayashi T., Makino K., Ohnishi M., Kurokawa K., Ishii K., Yokoyama K.,
RA   Han C.-G., Ohtsubo E., Nakayama K., Murata T., Tanaka M., Tobe T.,
RA   Iida T., Takami H., Honda T., Sasakawa C., Ogasawara N., Yasunaga T.,
RA   Kuhara S., Shiba T., Hattori M., Shinagawa H.;
RT   "Complete genome sequence of enterohemorrhagic Escherichia coli
RT   O157:H7 and genomic comparison with a laboratory strain K-12.";
RL   DNA Res. 8:11-22(2001).
CC   -!- FUNCTION: Member of the two-component regulatory system CpxA/CpxR.
CC       This system combats a variety of extracytoplasmic protein-mediated
CC       toxicities. It performs this function by increasing the synthesis
CC       of the periplasmic protease, DegP as well as that of CpxP protein
CC       (By similarity).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm (Probable).
CC   -!- PTM: Phosphorylated by CpxA (Potential).
CC   -!- SIMILARITY: Contains 1 response regulatory domain.
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DR   EMBL; AE005174; AAG59106.1; -; Genomic_DNA.
DR   EMBL; BA000007; BAB38261.1; -; Genomic_DNA.
DR   PIR; F86080; F86080.
DR   PIR; F91233; F91233.
DR   RefSeq; NP_290542.1; NC_002655.2.
DR   RefSeq; NP_312865.1; NC_002695.1.
DR   ProteinModelPortal; P0AE89; -.
DR   SMR; P0AE89; 3-228.
DR   STRING; 155864.Z5457; -.
DR   EnsemblBacteria; AAG59106; AAG59106; Z5457.
DR   EnsemblBacteria; BAB38261; BAB38261; BAB38261.
DR   GeneID; 915041; -.
DR   GeneID; 960233; -.
DR   KEGG; ece:Z5457; -.
DR   KEGG; ecs:ECs4838; -.
DR   PATRIC; 18359335; VBIEscCol44059_4817.
DR   eggNOG; COG0745; -.
DR   HOGENOM; HOG000034819; -.
DR   KO; K07662; -.
DR   OMA; HEILSYG; -.
DR   OrthoDB; EOG6G4VQG; -.
DR   BioCyc; ECOL386585:GJFA-4827-MONOMER; -.
DR   BioCyc; ECOO157:CPXR-MONOMER; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000156; F:phosphorelay response regulator activity; IEA:InterPro.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:UniProtKB-KW.
DR   GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR011006; CheY-like_superfamily.
DR   InterPro; IPR001867; Sig_transdc_resp-reg_C.
DR   InterPro; IPR001789; Sig_transdc_resp-reg_receiver.
DR   InterPro; IPR011991; WHTH_DNA-bd_dom.
DR   Pfam; PF00072; Response_reg; 1.
DR   Pfam; PF00486; Trans_reg_C; 1.
DR   SMART; SM00448; REC; 1.
DR   SMART; SM00862; Trans_reg_C; 1.
DR   SUPFAM; SSF52172; SSF52172; 1.
DR   PROSITE; PS50110; RESPONSE_REGULATORY; 1.
PE   3: Inferred from homology;
KW   Complete proteome; Cytoplasm; DNA-binding; Phosphoprotein;
KW   Transcription; Transcription regulation;
KW   Two-component regulatory system.
FT   CHAIN         1    232       Transcriptional regulatory protein CpxR.
FT                                /FTId=PRO_0000081079.
FT   DOMAIN        1    115       Response regulatory.
FT   MOD_RES      51     51       4-aspartylphosphate (By similarity).
SQ   SEQUENCE   232 AA;  26312 MW;  667FC2B246082F46 CRC64;
     MNKILLVDDD RELTSLLKEL LEMEGFNVIV AHDGEQALDL LDDSIDLLLL DVMMPKKNGI
     DTLKALRQTH QTPVIMLTAR GSELDRVLGL ELGADDYLPK PFNDRELVAR IRAILRRSHW
     SEQQQNNDNG SPTLEVDALV LNPGRQEASF DGQTLELTGT EFTLLYLLAQ HLGQVVSREH
     LSQEVLGKRL TPFDRAIDMH ISNLRRKLPD RKDGHPWFKT LRGRGYLMVS AS
//
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