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Database: UniProt
Entry: P0AEX5
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Original site: P0AEX5 
ID   KPPR_ECOLI              Reviewed;         289 AA.
AC   P0AEX5; P37307; P76684; Q2M721;
DT   20-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT   20-DEC-2005, sequence version 1.
DT   16-APR-2014, entry version 64.
DE   RecName: Full=Probable phosphoribulokinase;
DE            Short=PRK;
DE            Short=PRKase;
DE            EC=2.7.1.19;
DE   AltName: Full=Phosphopentokinase;
GN   Name=prkB; Synonyms=yhfF; OrderedLocusNames=b3355, JW3318;
OS   Escherichia coli (strain K12).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacteriales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=83333;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K12 / MG1655 / ATCC 47076;
RX   PubMed=9278503; DOI=10.1126/science.277.5331.1453;
RA   Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V.,
RA   Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F.,
RA   Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J.,
RA   Mau B., Shao Y.;
RT   "The complete genome sequence of Escherichia coli K-12.";
RL   Science 277:1453-1462(1997).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX   PubMed=16738553; DOI=10.1038/msb4100049;
RA   Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S.,
RA   Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.;
RT   "Highly accurate genome sequences of Escherichia coli K-12 strains
RT   MG1655 and W3110.";
RL   Mol. Syst. Biol. 2:E1-E5(2006).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 228-289.
RC   STRAIN=K12;
RX   PubMed=1756168; DOI=10.1016/0167-4781(91)90222-8;
RA   Bhasin R., Freundlich M.;
RT   "The nucleotide sequence of the Escherichia coli crp divergent RNA and
RT   an overlapping ORF.";
RL   Biochim. Biophys. Acta 1129:109-111(1991).
RN   [4]
RP   IDENTIFICATION.
RX   PubMed=7940673; DOI=10.1016/0968-0004(94)90067-1;
RA   Borodovsky M., Koonin E.V., Rudd K.E.;
RT   "New genes in old sequence: a strategy for finding genes in the
RT   bacterial genome.";
RL   Trends Biochem. Sci. 19:309-313(1994).
RN   [5]
RP   IDENTIFICATION.
RX   PubMed=7984428; DOI=10.1093/nar/22.22.4756;
RA   Borodovsky M., Rudd K.E., Koonin E.V.;
RT   "Intrinsic and extrinsic approaches for detecting genes in a bacterial
RT   genome.";
RL   Nucleic Acids Res. 22:4756-4767(1994).
RN   [6]
RP   IDENTIFICATION.
RX   PubMed=7920643; DOI=10.1038/ng0694-205;
RA   Robison K., Gilbert W., Church G.M.;
RT   "Large scale bacterial gene discovery by similarity search.";
RL   Nat. Genet. 7:205-214(1994).
CC   -!- CATALYTIC ACTIVITY: ATP + D-ribulose 5-phosphate = ADP + D-
CC       ribulose 1,5-bisphosphate.
CC   -!- SIMILARITY: Belongs to the phosphoribulokinase family.
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DR   EMBL; U18997; AAA58152.1; ALT_FRAME; Genomic_DNA.
DR   EMBL; U00096; AAC76380.1; -; Genomic_DNA.
DR   EMBL; AP009048; BAE77935.1; -; Genomic_DNA.
DR   EMBL; X61919; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   PIR; F65129; F65129.
DR   RefSeq; NP_417814.1; NC_000913.3.
DR   RefSeq; YP_492076.1; NC_007779.1.
DR   ProteinModelPortal; P0AEX5; -.
DR   SMR; P0AEX5; 2-288.
DR   DIP; DIP-10565N; -.
DR   IntAct; P0AEX5; 4.
DR   MINT; MINT-1286728; -.
DR   STRING; 511145.b3355; -.
DR   PaxDb; P0AEX5; -.
DR   PRIDE; P0AEX5; -.
DR   EnsemblBacteria; AAC76380; AAC76380; b3355.
DR   EnsemblBacteria; BAE77935; BAE77935; BAE77935.
DR   GeneID; 12930596; -.
DR   GeneID; 947862; -.
DR   KEGG; ecj:Y75_p3820; -.
DR   KEGG; eco:b3355; -.
DR   PATRIC; 32122144; VBIEscCol129921_3449.
DR   EchoBASE; EB2268; -.
DR   EcoGene; EG12365; prkB.
DR   eggNOG; COG3954; -.
DR   HOGENOM; HOG000272991; -.
DR   KO; K00855; -.
DR   OMA; LGRHISY; -.
DR   OrthoDB; EOG683S6G; -.
DR   ProtClustDB; PRK15453; -.
DR   BioCyc; EcoCyc:EG12365-MONOMER; -.
DR   BioCyc; ECOL316407:JW3318-MONOMER; -.
DR   PRO; PR:P0AEX5; -.
DR   Genevestigator; P0AEX5; -.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0008974; F:phosphoribulokinase activity; IEA:UniProtKB-EC.
DR   GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR006082; PRK.
DR   InterPro; IPR006083; PRK/URK.
DR   Pfam; PF00485; PRK; 1.
DR   PRINTS; PR00478; PHRIBLKINASE.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   PROSITE; PS00567; PHOSPHORIBULOKINASE; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Complete proteome; Kinase; Nucleotide-binding;
KW   Reference proteome; Transferase.
FT   CHAIN         1    289       Probable phosphoribulokinase.
FT                                /FTId=PRO_0000201952.
FT   NP_BIND      12     20       ATP (By similarity).
FT   CONFLICT    250    250       Q -> L (in Ref. 3).
SQ   SEQUENCE   289 AA;  32344 MW;  A98EE1A322148DAE CRC64;
     MSAKHPVIAV TGSSGAGTTT TSLAFRKIFA QLNLHAAEVE GDSFHRYTRP EMDMAIRKAR
     DAGRHISYFG PEANDFGLLE QTFIEYGQSG KGKSRKYLHT YDEAVPWNQV PGTFTPWQPL
     PEPTDVLFYE GLHGGVVTPQ HNVAQHVDLL VGVVPIVNLE WIQKLIRDTS ERGHSREAVM
     DSVVRSMEDY INYITPQFSR THLNFQRVPT VDTSNPFAAK GIPSLDESFV VIHFRNLEGI
     DFPWLLAMLQ GSFISHINTL VVPGGKMGLA MELIMLPLVQ RLMEGKKIE
//
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