ID NARL_ECOL6 Reviewed; 216 AA.
AC P0AF29; P10957;
DT 20-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT 20-DEC-2005, sequence version 1.
DT 01-MAY-2013, entry version 56.
DE RecName: Full=Nitrate/nitrite response regulator protein NarL;
GN Name=narL; OrderedLocusNames=c1681;
OS Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacteriales;
OC Enterobacteriaceae; Escherichia.
OX NCBI_TaxID=199310;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CFT073 / ATCC 700928 / UPEC;
RX PubMed=12471157; DOI=10.1073/pnas.252529799;
RA Welch R.A., Burland V., Plunkett G. III, Redford P., Roesch P.,
RA Rasko D., Buckles E.L., Liou S.-R., Boutin A., Hackett J., Stroud D.,
RA Mayhew G.F., Rose D.J., Zhou S., Schwartz D.C., Perna N.T.,
RA Mobley H.L.T., Donnenberg M.S., Blattner F.R.;
RT "Extensive mosaic structure revealed by the complete genome sequence
RT of uropathogenic Escherichia coli.";
RL Proc. Natl. Acad. Sci. U.S.A. 99:17020-17024(2002).
CC -!- FUNCTION: This protein activates the expression of the nitrate
CC reductase (narGHJI) and formate dehydrogenase-N (fdnGHI) operons
CC and represses the transcription of the fumarate reductase
CC (frdABCD) operon in response to a nitrate/nitrite induction signal
CC transmitted by either the NarX or NarQ proteins (By similarity).
CC -!- SIMILARITY: Contains 1 HTH luxR-type DNA-binding domain.
CC -!- SIMILARITY: Contains 1 response regulatory domain.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAN80148.1; Type=Erroneous initiation;
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DR EMBL; AE014075; AAN80148.1; ALT_INIT; Genomic_DNA.
DR RefSeq; NP_753586.1; NC_004431.1.
DR ProteinModelPortal; P0AF29; -.
DR SMR; P0AF29; 5-216.
DR STRING; 199310.c1681; -.
DR PRIDE; P0AF29; -.
DR EnsemblBacteria; AAN80148; AAN80148; c1681.
DR GeneID; 1035460; -.
DR KEGG; ecc:c1681; -.
DR PATRIC; 18281282; VBIEscCol75197_1562.
DR HOGENOM; HOG000034813; -.
DR KO; K07684; -.
DR OMA; NHEDDVV; -.
DR ProtClustDB; PRK10651; -.
DR GO; GO:0005622; C:intracellular; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0000156; F:phosphorelay response regulator activity; IEA:InterPro.
DR GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR GO; GO:0003700; F:sequence-specific DNA binding transcription factor activity; IEA:InterPro.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:GOC.
DR GO; GO:0042128; P:nitrate assimilation; IEA:UniProtKB-KW.
DR GO; GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
DR Gene3D; 1.10.10.10; -; 1.
DR InterPro; IPR011006; CheY-like_superfamily.
DR InterPro; IPR016032; Sig_transdc_resp-reg_C-effctor.
DR InterPro; IPR001789; Sig_transdc_resp-reg_receiver.
DR InterPro; IPR000792; Tscrpt_reg_LuxR_C.
DR InterPro; IPR011991; WHTH_DNA-bd_dom.
DR Pfam; PF00196; GerE; 1.
DR Pfam; PF00072; Response_reg; 1.
DR PRINTS; PR00038; HTHLUXR.
DR SMART; SM00421; HTH_LUXR; 1.
DR SMART; SM00448; REC; 1.
DR SUPFAM; SSF46894; Bipartite_resp_reg_C-effector; 1.
DR SUPFAM; SSF52172; CheY_like; 1.
DR PROSITE; PS00622; HTH_LUXR_1; 1.
DR PROSITE; PS50043; HTH_LUXR_2; 1.
DR PROSITE; PS50110; RESPONSE_REGULATORY; 1.
PE 3: Inferred from homology;
KW Activator; ATP-binding; Complete proteome; DNA-binding;
KW Nitrate assimilation; Nucleotide-binding; Phosphoprotein; Repressor;
KW Transcription; Transcription regulation;
KW Two-component regulatory system.
FT CHAIN 1 216 Nitrate/nitrite response regulator
FT protein NarL.
FT /FTId=PRO_0000081147.
FT DOMAIN 8 124 Response regulatory.
FT DOMAIN 149 214 HTH luxR-type.
FT DNA_BIND 173 192 H-T-H motif (By similarity).
FT MOD_RES 59 59 4-aspartylphosphate (By similarity).
SQ SEQUENCE 216 AA; 23927 MW; 7DED78E4EF7EC57D CRC64;
MSNQEPATIL LIDDHPMLRT GVKQLISMAP DITVVGEASN GEQGIELAES LDPDLILLDL
NMPGMNGLET LDKLREKSLS GRIVVFSVSN HEEDVVTALK RGADGYLLKD MEPEDLLKAL
HQAAAGEMVL SEALTPVLAA SLRANRATTE RDVNQLTPRE RDILKLIAQG LPNKMIARRL
DITESTVKVH VKHMLKKMKL KSRVEAAVWV HQERIF
//
