ID   OSTCN_MACEU             Reviewed;          49 AA.
AC   P0C226;
DT   28-NOV-2006, integrated into UniProtKB/Swiss-Prot.
DT   28-NOV-2006, sequence version 1.
DT   06-MAR-2013, entry version 20.
DE   RecName: Full=Osteocalcin;
DE   AltName: Full=Bone Gla protein;
DE            Short=BGP;
DE   AltName: Full=Gamma-carboxyglutamic acid-containing protein;
GN   Name=BGLAP;
OS   Macropus eugenii (Tammar wallaby).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Metatheria; Diprotodontia; Macropodidae; Macropus.
OX   NCBI_TaxID=9315;
RN   [1]
RP   PROTEIN SEQUENCE, HYDROXYLATION AT PRO-9, AND GAMMA-CARBOXYGLUTAMATION
RP   AT GLU-21 AND GLU-24.
RC   TISSUE=Bone;
RX   PubMed=6332627;
RA   Huq N.L., Teh L.-C., Christie D.L., Chapman G.E.;
RT   "The amino acid sequences of goat, pig and wallaby osteocalcins.";
RL   Biochem. Int. 8:521-527(1984).
CC   -!- FUNCTION: Constitutes 1-2% of the total bone protein. It binds
CC       strongly to apatite and calcium.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- PTM: Gamma-carboxyglutamate residues are formed by vitamin K
CC       dependent carboxylation. These residues are essential for the
CC       binding of calcium.
CC   -!- SIMILARITY: Belongs to the osteocalcin/matrix Gla protein family.
CC   -!- SIMILARITY: Contains 1 Gla (gamma-carboxy-glutamate) domain.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   ProteinModelPortal; P0C226; -.
DR   SMR; P0C226; 13-49.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0031214; P:biomineral tissue development; IEA:UniProtKB-KW.
DR   GO; GO:0030500; P:regulation of bone mineralization; IEA:InterPro.
DR   InterPro; IPR000294; GLA_domain.
DR   InterPro; IPR002384; Osteocalcin/MGP.
DR   Pfam; PF00594; Gla; 1.
DR   PRINTS; PR00002; GLABONE.
DR   SMART; SM00069; GLA; 1.
DR   SUPFAM; SSF57630; VitK_dep_GLA; 1.
DR   PROSITE; PS00011; GLA_1; 1.
DR   PROSITE; PS50998; GLA_2; 1.
PE   1: Evidence at protein level;
KW   Biomineralization; Calcium; Direct protein sequencing; Disulfide bond;
KW   Gamma-carboxyglutamic acid; Hydroxylation; Metal-binding; Secreted.
FT   CHAIN         1     49       Osteocalcin.
FT                                /FTId=PRO_0000260272.
FT   DOMAIN        1     47       Gla.
FT   METAL        17     17       Calcium 3 (By similarity).
FT   METAL        21     21       Calcium 2 (By similarity).
FT   METAL        24     24       Calcium 1 (By similarity).
FT   METAL        24     24       Calcium 2 (By similarity).
FT   METAL        30     30       Calcium 1 (By similarity).
FT   MOD_RES       9      9       Hydroxyproline.
FT   MOD_RES      17     17       4-carboxyglutamate (By similarity).
FT   MOD_RES      21     21       4-carboxyglutamate.
FT   MOD_RES      24     24       4-carboxyglutamate.
FT   DISULFID     23     29       By similarity.
SQ   SEQUENCE   49 AA;  5742 MW;  5E20AED4D5FF8678 CRC64;
     YLYQTLGFPA PYPDPQENKR EVCELNPDCD ELADHIGFQE AYRRFYGTA
//