GenomeNet

Database: UniProt
Entry: P0C596
LinkDB: P0C596
Original site: P0C596 
ID   DUPD1_PIG               Reviewed;         222 AA.
AC   P0C596;
DT   24-JUL-2007, integrated into UniProtKB/Swiss-Prot.
DT   24-JUL-2007, sequence version 1.
DT   11-JUN-2014, entry version 35.
DE   RecName: Full=Dual specificity phosphatase DUPD1;
DE            EC=3.1.3.16;
DE            EC=3.1.3.48;
GN   Name=DUPD1;
OS   Sus scrofa (Pig).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Suina; Suidae;
OC   Sus.
OX   NCBI_TaxID=9823;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   Porcine genome sequencing project;
RL   Submitted (JAN-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY: Protein tyrosine phosphate + H(2)O = protein
CC       tyrosine + phosphate.
CC   -!- CATALYTIC ACTIVITY: [a protein]-serine/threonine phosphate + H(2)O
CC       = [a protein]-serine/threonine + phosphate.
CC   -!- SUBUNIT: Homodimer (By similarity).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
CC   -!- SIMILARITY: Belongs to the protein-tyrosine phosphatase family.
CC       Non-receptor class dual specificity subfamily.
CC   -!- SIMILARITY: Contains 1 tyrosine-protein phosphatase domain.
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DR   EMBL; CT737343; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; P0C596; -.
DR   STRING; 9823.ENSSSCP00000011002; -.
DR   PRIDE; P0C596; -.
DR   eggNOG; NOG270281; -.
DR   HOGENOM; HOG000233767; -.
DR   HOVERGEN; HBG001524; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0004725; F:protein tyrosine phosphatase activity; IEA:UniProtKB-EC.
DR   GO; GO:0008138; F:protein tyrosine/serine/threonine phosphatase activity; IEA:InterPro.
DR   Gene3D; 3.90.190.10; -; 1.
DR   InterPro; IPR020417; Atypical_DUSP.
DR   InterPro; IPR020405; Atypical_DUSP_famA.
DR   InterPro; IPR000340; Dual-sp_phosphatase_cat-dom.
DR   InterPro; IPR020422; Dual-sp_phosphatase_subgr_cat.
DR   InterPro; IPR024950; DUSP.
DR   InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR   InterPro; IPR000387; Tyr/Dual-sp_Pase.
DR   InterPro; IPR016130; Tyr_Pase_AS.
DR   PANTHER; PTHR10159; PTHR10159; 1.
DR   Pfam; PF00782; DSPc; 1.
DR   PRINTS; PR01908; ADSPHPHTASE.
DR   PRINTS; PR01909; ADSPHPHTASEA.
DR   SMART; SM00195; DSPc; 1.
DR   SUPFAM; SSF52799; SSF52799; 1.
DR   PROSITE; PS00383; TYR_PHOSPHATASE_1; 1.
DR   PROSITE; PS50056; TYR_PHOSPHATASE_2; 1.
DR   PROSITE; PS50054; TYR_PHOSPHATASE_DUAL; 1.
PE   3: Inferred from homology;
KW   Complete proteome; Cytoplasm; Hydrolase; Protein phosphatase;
KW   Reference proteome.
FT   CHAIN         1    222       Dual specificity phosphatase DUPD1.
FT                                /FTId=PRO_0000295882.
FT   DOMAIN       54    201       Tyrosine-protein phosphatase.
FT   REGION      146    153       Substrate binding (By similarity).
FT   ACT_SITE    147    147       Phosphocysteine intermediate (By
FT                                similarity).
SQ   SEQUENCE   222 AA;  25132 MW;  3BF05F9905E94649 CRC64;
     MTSGESKTSL KNAYPAAKKL LPKVEEEGEA EEYCTPGAFE LERLFWKGSP QYTHVNEVWP
     KLYIGDEATA LDRYGLQKAG FTHVLNAAHG RWNVDTGPDY YRDMAIEYHG VEADDLPTFD
     LSIFFYPAAA FIDAALRYEH SKILVHCAMG RSRSATLVLA YLMIHRNMTL VDAIRQVAKN
     RCVLPNRGFL KQLRELDKQL VQQRRGAQHR GEAGEKAGEK EP
//
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