ID DUPD1_PIG Reviewed; 222 AA.
AC P0C596;
DT 24-JUL-2007, integrated into UniProtKB/Swiss-Prot.
DT 24-JUL-2007, sequence version 1.
DT 06-MAR-2013, entry version 29.
DE RecName: Full=Dual specificity phosphatase DUPD1;
DE EC=3.1.3.16;
DE EC=3.1.3.48;
GN Name=DUPD1;
OS Sus scrofa (Pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Suina; Suidae;
OC Sus.
OX NCBI_TaxID=9823;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Porcine genome sequencing project;
RL Submitted (JAN-2007) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY: Protein tyrosine phosphate + H(2)O = protein
CC tyrosine + phosphate.
CC -!- CATALYTIC ACTIVITY: A phosphoprotein + H(2)O = a protein +
CC phosphate.
CC -!- SUBUNIT: Homodimer (By similarity).
CC -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
CC -!- SIMILARITY: Belongs to the protein-tyrosine phosphatase family.
CC Non-receptor class dual specificity subfamily.
CC -!- SIMILARITY: Contains 1 tyrosine-protein phosphatase domain.
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DR EMBL; CT737343; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR ProteinModelPortal; P0C596; -.
DR PRIDE; P0C596; -.
DR eggNOG; NOG270281; -.
DR HOGENOM; HOG000233767; -.
DR HOVERGEN; HBG001524; -.
DR OrthoDB; EOG4R23W1; -.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0004725; F:protein tyrosine phosphatase activity; IEA:EC.
DR GO; GO:0008138; F:protein tyrosine/serine/threonine phosphatase activity; IEA:InterPro.
DR GO; GO:0035335; P:peptidyl-tyrosine dephosphorylation; IEA:GOC.
DR InterPro; IPR020417; Atypical_DUSP.
DR InterPro; IPR020405; Atypical_DUSP_famA.
DR InterPro; IPR000340; Dual-sp_phosphatase_cat-dom.
DR InterPro; IPR020422; Dual-sp_phosphatase_subgr_cat.
DR InterPro; IPR024950; DUSP.
DR InterPro; IPR000387; Tyr/Dual-sp_Pase.
DR InterPro; IPR016130; Tyr_Pase_AS.
DR PANTHER; PTHR10159; PTHR10159; 1.
DR Pfam; PF00782; DSPc; 1.
DR PRINTS; PR01908; ADSPHPHTASE.
DR PRINTS; PR01909; ADSPHPHTASEA.
DR SMART; SM00195; DSPc; 1.
DR PROSITE; PS00383; TYR_PHOSPHATASE_1; 1.
DR PROSITE; PS50056; TYR_PHOSPHATASE_2; 1.
DR PROSITE; PS50054; TYR_PHOSPHATASE_DUAL; 1.
PE 3: Inferred from homology;
KW Complete proteome; Cytoplasm; Hydrolase; Protein phosphatase;
KW Reference proteome.
FT CHAIN 1 222 Dual specificity phosphatase DUPD1.
FT /FTId=PRO_0000295882.
FT DOMAIN 54 201 Tyrosine-protein phosphatase.
FT REGION 146 153 Substrate binding (By similarity).
FT ACT_SITE 147 147 Phosphocysteine intermediate (By
FT similarity).
SQ SEQUENCE 222 AA; 25132 MW; 3BF05F9905E94649 CRC64;
MTSGESKTSL KNAYPAAKKL LPKVEEEGEA EEYCTPGAFE LERLFWKGSP QYTHVNEVWP
KLYIGDEATA LDRYGLQKAG FTHVLNAAHG RWNVDTGPDY YRDMAIEYHG VEADDLPTFD
LSIFFYPAAA FIDAALRYEH SKILVHCAMG RSRSATLVLA YLMIHRNMTL VDAIRQVAKN
RCVLPNRGFL KQLRELDKQL VQQRRGAQHR GEAGEKAGEK EP
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