ID MDV1_CRYNJ Reviewed; 757 AA.
AC P0CS44; Q55K39; Q5K9G0;
DT 28-JUN-2011, integrated into UniProtKB/Swiss-Prot.
DT 28-JUN-2011, sequence version 1.
DT 27-MAR-2024, entry version 52.
DE RecName: Full=Mitochondrial division protein 1;
GN Name=MDV1; OrderedLocusNames=CNK02070;
OS Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC
OS MYA-565) (Filobasidiella neoformans).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Tremellomycetes;
OC Tremellales; Cryptococcaceae; Cryptococcus;
OC Cryptococcus neoformans species complex.
OX NCBI_TaxID=214684;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JEC21 / ATCC MYA-565;
RX PubMed=15653466; DOI=10.1126/science.1103773;
RA Loftus B.J., Fung E., Roncaglia P., Rowley D., Amedeo P., Bruno D.,
RA Vamathevan J., Miranda M., Anderson I.J., Fraser J.A., Allen J.E.,
RA Bosdet I.E., Brent M.R., Chiu R., Doering T.L., Donlin M.J., D'Souza C.A.,
RA Fox D.S., Grinberg V., Fu J., Fukushima M., Haas B.J., Huang J.C.,
RA Janbon G., Jones S.J.M., Koo H.L., Krzywinski M.I., Kwon-Chung K.J.,
RA Lengeler K.B., Maiti R., Marra M.A., Marra R.E., Mathewson C.A.,
RA Mitchell T.G., Pertea M., Riggs F.R., Salzberg S.L., Schein J.E.,
RA Shvartsbeyn A., Shin H., Shumway M., Specht C.A., Suh B.B., Tenney A.,
RA Utterback T.R., Wickes B.L., Wortman J.R., Wye N.H., Kronstad J.W.,
RA Lodge J.K., Heitman J., Davis R.W., Fraser C.M., Hyman R.W.;
RT "The genome of the basidiomycetous yeast and human pathogen Cryptococcus
RT neoformans.";
RL Science 307:1321-1324(2005).
CC -!- FUNCTION: Involved in mitochondrial fission. Acts as an adapter protein
CC required to form mitochondrial fission complexes. Formation of these
CC complexes is required to promote constriction and fission of the
CC mitochondrial compartment at a late step in mitochondrial division (By
CC similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion outer membrane {ECO:0000250};
CC Peripheral membrane protein {ECO:0000250}; Cytoplasmic side
CC {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the WD repeat MDV1/CAF4 family. {ECO:0000305}.
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DR EMBL; AE017351; AAW46166.1; -; Genomic_DNA.
DR RefSeq; XP_567683.1; XM_567683.1.
DR AlphaFoldDB; P0CS44; -.
DR SMR; P0CS44; -.
DR STRING; 214684.P0CS44; -.
DR PaxDb; 214684-P0CS44; -.
DR EnsemblFungi; AAW46166; AAW46166; CNK02070.
DR GeneID; 3254504; -.
DR KEGG; cne:CNK02070; -.
DR VEuPathDB; FungiDB:CNK02070; -.
DR eggNOG; KOG4155; Eukaryota.
DR HOGENOM; CLU_012350_0_0_1; -.
DR InParanoid; P0CS44; -.
DR OMA; ERLRYMD; -.
DR OrthoDB; 587035at2759; -.
DR Proteomes; UP000002149; Chromosome 11.
DR GO; GO:0005741; C:mitochondrial outer membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR CDD; cd00200; WD40; 1.
DR Gene3D; 6.10.280.220; -; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 3.
DR InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR22847:SF637; WD REPEAT DOMAIN 5; 1.
DR PANTHER; PTHR22847; WD40 REPEAT PROTEIN; 1.
DR Pfam; PF00400; WD40; 4.
DR PRINTS; PR00320; GPROTEINBRPT.
DR SMART; SM00320; WD40; 7.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 4.
DR PROSITE; PS50082; WD_REPEATS_2; 6.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 3: Inferred from homology;
KW Coiled coil; Membrane; Mitochondrion; Mitochondrion outer membrane;
KW Reference proteome; Repeat; WD repeat.
FT CHAIN 1..757
FT /note="Mitochondrial division protein 1"
FT /id="PRO_0000330104"
FT REPEAT 353..394
FT /note="WD 1"
FT REPEAT 396..432
FT /note="WD 2"
FT REPEAT 491..528
FT /note="WD 3"
FT REPEAT 602..645
FT /note="WD 4"
FT REPEAT 648..685
FT /note="WD 5"
FT REPEAT 687..724
FT /note="WD 6"
FT REPEAT 728..757
FT /note="WD 7"
FT REGION 69..88
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 312..336
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 454..489
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 538..564
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 225..300
FT /evidence="ECO:0000255"
FT COMPBIAS 550..564
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 757 AA; 82615 MW; CD0CA06DAE569597 CRC64;
MANHHDHDKP LRSALDPISS PYFSSLNGTL SIAKEVLIGP FQGDHRRSES ARILSDLAPS
LMQPRFLNAA SSSQQSLSKS SHPGAPYPLL RLPTNLPFNK SSRPTASSLA ILEAVDNLAS
LSLGDVSHPQ NGQNSPSLIR GFKATIPSSE LAKQRRRMVR GGIVDEDLGG KIGLKKLGDR
ARGLLTEKGE DEEDGELGVG RHAVKKRRKK RESRRFTEGR HLEGKLRLED LAKQADEIGQ
DKENLHVRQS LIQSEIAEVG AKIDALEDIR RHLEASLLHL QEEDLELDDE LEGVQELMAS
PAIKAAAGAK SLPLSSSGAG ISNKSSRRRK GPAFLPSEHD ELPSGVAFMT LNGHTAPITA
LDFDEPYGML VTAGQDDVVK VWDLCDGEEI GQLRGHRGTV KALQVEDTLC LTGGADGNVR
LWDLRMVEDY EERLHTQLAE LARQDPLERI AEQRAHEEDG EHAEQDDELP DGTLQDPQPG
DGSPCVRTLE GHSKSVTSLY YEDGCLVTGS SDKTIRQWDV ATGQCVLTMD ILWAISNPPP
PPSSVPPQRP PRLSHRSSTS FGSNTYEDIL PSPGASLVGM SGAALLGAAT GQNFAVPTPP
YADGTWEMYQ DFVGGVQFWG YALASGSGDG GVRMWDMRTG QAHRTLIGHT APVTCLQFDE
QYIVTGSLDR TVRIWDLRMG SVSEVHKYEY PVTALQFDSR KVVACTGENG VEVYNRTTHA
HSRLVVNGHT KPAEKMRFID KYLVSGGRDG CAKVWAM
//
