ID COFB_DICDI Reviewed; 137 AA.
AC P0DJ27; P54706; Q54DU6;
DT 19-OCT-2011, integrated into UniProtKB/Swiss-Prot.
DT 19-OCT-2011, sequence version 1.
DT 01-MAY-2013, entry version 16.
DE RecName: Full=Cofilin-1B;
GN Name=cofB; Synonyms=cof2, dcof2; ORFNames=DDB_G0291970;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Mycetozoa; Dictyosteliida; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=AX2;
RX PubMed=7738034; DOI=10.1074/jbc.270.18.10923;
RA Aizawa H., Sutoh K., Tsubuki S., Kawashima S., Ishii A., Yahara I.;
RT "Identification, characterization, and intracellular distribution of
RT cofilin in Dictyostelium discoideum.";
RL J. Biol. Chem. 270:10923-10932(1995).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A.,
RA Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q.,
RA Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F.,
RA Bankier A.T., Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P.,
RA Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P.,
RA Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N.,
RA Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M.,
RA Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I.,
RA Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R.,
RA Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C.,
RA Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D.,
RA Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S.,
RA Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T.,
RA Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A.,
RA Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M.,
RA Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G.,
RA Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
RN [3]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC STRAIN=AX2;
RX PubMed=16926386; DOI=10.1074/mcp.M600113-MCP200;
RA Gotthardt D., Blancheteau V., Bosserhoff A., Ruppert T., Delorenzi M.,
RA Soldati T.;
RT "Proteomics fingerprinting of phagosome maturation and evidence for
RT the role of a Galpha during uptake.";
RL Mol. Cell. Proteomics 5:2228-2243(2006).
CC -!- FUNCTION: Controls reversibly actin polymerization and
CC depolymerization in a pH-sensitive manner. It has the ability to
CC bind G- and F-actin in a 1:1 ratio of cofilin to actin. It is the
CC major component of intranuclear and cytoplasmic actin rods (By
CC similarity).
CC -!- SUBCELLULAR LOCATION: Nucleus matrix (By similarity). Cytoplasm,
CC cytoskeleton (By similarity).
CC -!- SIMILARITY: Belongs to the actin-binding proteins ADF family.
CC -!- SIMILARITY: Contains 1 ADF-H domain.
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DR EMBL; D37981; BAA07199.1; -; Genomic_DNA.
DR EMBL; AAFI02000187; EAL61341.1; -; Genomic_DNA.
DR RefSeq; XP_629776.1; XM_629774.1.
DR RefSeq; XP_642259.1; XM_637167.1.
DR ProteinModelPortal; P0DJ27; -.
DR PRIDE; P0DJ27; -.
DR GeneID; 8621468; -.
DR GeneID; 8628452; -.
DR KEGG; ddi:DDB_G0277833; -.
DR KEGG; ddi:DDB_G0291970; -.
DR KO; K05765; -.
DR GO; GO:0015629; C:actin cytoskeleton; IEA:InterPro.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0016363; C:nuclear matrix; IEA:UniProtKB-SubCell.
DR GO; GO:0030042; P:actin filament depolymerization; IEA:InterPro.
DR GO; GO:0009617; P:response to bacterium; IEP:dictyBase.
DR GO; GO:0030587; P:sorocarp development; TAS:dictyBase.
DR InterPro; IPR002108; Actin-bd_cofilin/tropomyosin.
DR InterPro; IPR017904; ADF/Cofilin/Destrin.
DR PANTHER; PTHR11913; PTHR11913; 1.
DR Pfam; PF00241; Cofilin_ADF; 1.
DR PRINTS; PR00006; COFILIN.
DR SMART; SM00102; ADF; 1.
DR PROSITE; PS51263; ADF_H; 1.
PE 1: Evidence at protein level;
KW Actin-binding; Complete proteome; Cytoplasm; Cytoskeleton; Nucleus;
KW Reference proteome.
FT CHAIN 1 137 Cofilin-1B.
FT /FTId=PRO_0000413616.
FT DOMAIN 2 135 ADF-H.
SQ SEQUENCE 137 AA; 15224 MW; 0C0B0673354F46F3 CRC64;
MSSGIALAPN CVSTFNDLKL GRKYGGIIYR ISDDSKEIIV DSTLPAGCSF DEFTKCLPEN
ECRYVVLDYQ YKEEGAQKSK ICFVAWCPDT ANIKKKMMAT SSKDSLRKAC VGIQVEIQGT
DASEVKDSCF YEKCTKI
//
