ID   CERC_SCHMA              Reviewed;         264 AA.
AC   P12546;
DT   01-OCT-1989, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1989, sequence version 1.
DT   03-APR-2013, entry version 63.
DE   RecName: Full=Cercarial protease;
DE            EC=3.4.21.-;
DE   AltName: Full=Cercarial elastase;
DE   Flags: Precursor;
OS   Schistosoma mansoni (Blood fluke).
OC   Eukaryota; Metazoa; Platyhelminthes; Trematoda; Digenea; Strigeidida;
OC   Schistosomatoidea; Schistosomatidae; Schistosoma.
OX   NCBI_TaxID=6183;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=3166457;
RA   Newport G.R., McKerrow J.H., Hedstrom R., Petitt M., McGarrigle L.,
RA   Barr P.J., Agabian N.;
RT   "Cloning of the proteinase that facilitates infection by schistosome
RT   parasites.";
RL   J. Biol. Chem. 263:13179-13184(1988).
CC   -!- FUNCTION: This protease cleaves elastin and thus facilitates
CC       penetration of schistosome parasite larvae through elastin-rich
CC       tissue of the host.
CC   -!- ENZYME REGULATION: Activated by an autocatalytic mechanism.
CC   -!- TISSUE SPECIFICITY: Acetabular (penetration) glands.
CC   -!- SIMILARITY: Belongs to the peptidase S1 family.
CC   -!- SIMILARITY: Contains 1 peptidase S1 domain.
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DR   EMBL; J03946; AAA29864.1; -; mRNA.
DR   PIR; A28942; A28942.
DR   ProteinModelPortal; P12546; -.
DR   MEROPS; S01.144; -.
DR   GO; GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   InterPro; IPR001254; Peptidase_S1.
DR   InterPro; IPR018114; Peptidase_S1_AS.
DR   InterPro; IPR001314; Peptidase_S1A.
DR   InterPro; IPR009003; Trypsin-like_Pept_dom.
DR   Pfam; PF00089; Trypsin; 1.
DR   PRINTS; PR00722; CHYMOTRYPSIN.
DR   SMART; SM00020; Tryp_SPc; 1.
DR   SUPFAM; SSF50494; Pept_Ser_Cys; 1.
DR   PROSITE; PS50240; TRYPSIN_DOM; 1.
DR   PROSITE; PS00134; TRYPSIN_HIS; 1.
DR   PROSITE; PS00135; TRYPSIN_SER; FALSE_NEG.
PE   2: Evidence at transcript level;
KW   Disulfide bond; Hydrolase; Protease; Serine protease; Signal; Zymogen.
FT   SIGNAL        1     19       Potential.
FT   PROPEP       20     27       Potential.
FT                                /FTId=PRO_0000028440.
FT   CHAIN        28    264       Cercarial protease.
FT                                /FTId=PRO_0000028441.
FT   DOMAIN       28    264       Peptidase S1.
FT   ACT_SITE     68     68       Charge relay system (By similarity).
FT   ACT_SITE    126    126       Charge relay system (By similarity).
FT   ACT_SITE    218    218       Charge relay system (By similarity).
FT   DISULFID     53     69       By similarity.
FT   DISULFID    192    202       By similarity.
SQ   SEQUENCE   264 AA;  28545 MW;  E2E5129A7C5D5010 CRC64;
     MSNRWRFVVV VTLFTYCLTF ERVSTWLIRS GEPVQHPAEF PFIAFLTTER TMCTGSLVST
     RAVLTAGHCV CSPLPVIRVS FLTLRNGDQQ GIHHQPSGVK VAPGYMPSCM SARQRRPIAQ
     TLSGFDIAIV MLAQMVNLQS GIRVISLPQP SDIPPPGTGV FIVGYGRDDN DRDPSRKNGG
     ILKKGRATIM ECRHATNGNP ICVKAGQNFG QLPAPGDSGG PLLPSLQGPV LGVVSHGVTL
     PNLPDIIVEY ASVARMLDFV RSNI
//