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Database: UniProt
Entry: P14062
LinkDB: P14062
Original site: P14062 
ID   6PGD_SALTY              Reviewed;         468 AA.
AC   P14062;
DT   01-JAN-1990, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1990, sequence version 1.
DT   09-JUL-2014, entry version 116.
DE   RecName: Full=6-phosphogluconate dehydrogenase, decarboxylating;
DE            EC=1.1.1.44;
GN   Name=gnd; OrderedLocusNames=STM2081;
OS   Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacteriales;
OC   Enterobacteriaceae; Salmonella.
OX   NCBI_TaxID=99287;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=LT2;
RX   PubMed=2671649; DOI=10.1007/BF00330960;
RA   Reeves P., Stevenson G.;
RT   "Cloning and nucleotide sequence of the Salmonella typhimurium LT2 gnd
RT   gene and its homology with the corresponding sequence of Escherichia
RT   coli K12.";
RL   Mol. Gen. Genet. 217:182-184(1989).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=LT2;
RX   PubMed=1938920;
RA   Dykhuizen D.E., Green L.;
RT   "Recombination in Escherichia coli and the definition of biological
RT   species.";
RL   J. Bacteriol. 173:7257-7268(1991).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=LT2 / SGSC1412 / ATCC 700720;
RX   PubMed=11677609; DOI=10.1038/35101614;
RA   McClelland M., Sanderson K.E., Spieth J., Clifton S.W., Latreille P.,
RA   Courtney L., Porwollik S., Ali J., Dante M., Du F., Hou S., Layman D.,
RA   Leonard S., Nguyen C., Scott K., Holmes A., Grewal N., Mulvaney E.,
RA   Ryan E., Sun H., Florea L., Miller W., Stoneking T., Nhan M.,
RA   Waterston R., Wilson R.K.;
RT   "Complete genome sequence of Salmonella enterica serovar Typhimurium
RT   LT2.";
RL   Nature 413:852-856(2001).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-57.
RC   STRAIN=LT2;
RX   PubMed=1710759; DOI=10.1111/j.1365-2958.1991.tb00741.x;
RA   Jiang X.-M., Neal B., Santiago F., Lee S.J., Romana L.K., Reeves P.R.;
RT   "Structure and sequence of the rfb (O antigen) gene cluster of
RT   Salmonella serovar typhimurium (strain LT2).";
RL   Mol. Microbiol. 5:695-713(1991).
CC   -!- FUNCTION: Catalyzes the oxidative decarboxylation of 6-
CC       phosphogluconate to ribulose 5-phosphate and CO(2), with
CC       concomitant reduction of NADP to NADPH (By similarity).
CC   -!- CATALYTIC ACTIVITY: 6-phospho-D-gluconate + NADP(+) = D-ribulose
CC       5-phosphate + CO(2) + NADPH.
CC   -!- PATHWAY: Carbohydrate degradation; pentose phosphate pathway; D-
CC       ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage):
CC       step 3/3.
CC   -!- SUBUNIT: Homodimer (By similarity).
CC   -!- SIMILARITY: Belongs to the 6-phosphogluconate dehydrogenase
CC       family.
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DR   EMBL; X15651; CAA33677.1; -; Genomic_DNA.
DR   EMBL; M64332; AAA27137.1; -; Genomic_DNA.
DR   EMBL; AE006468; AAL20985.1; -; Genomic_DNA.
DR   EMBL; X56793; CAA40131.1; -; Genomic_DNA.
DR   PIR; S04397; S04397.
DR   RefSeq; NP_461026.1; NC_003197.1.
DR   ProteinModelPortal; P14062; -.
DR   SMR; P14062; 1-466.
DR   STRING; 99287.STM2081; -.
DR   PaxDb; P14062; -.
DR   PRIDE; P14062; -.
DR   EnsemblBacteria; AAL20985; AAL20985; STM2081.
DR   GeneID; 1253602; -.
DR   KEGG; stm:STM2081; -.
DR   PATRIC; 32382745; VBISalEnt20916_2203.
DR   eggNOG; COG0362; -.
DR   HOGENOM; HOG000255147; -.
DR   KO; K00033; -.
DR   OMA; DKDGVFH; -.
DR   OrthoDB; EOG6MSS4W; -.
DR   PhylomeDB; P14062; -.
DR   BioCyc; SENT99287:GCTI-2093-MONOMER; -.
DR   UniPathway; UPA00115; UER00410.
DR   GO; GO:0050661; F:NADP binding; IEA:InterPro.
DR   GO; GO:0004616; F:phosphogluconate dehydrogenase (decarboxylating) activity; ISS:UniProtKB.
DR   GO; GO:0019521; P:D-gluconate metabolic process; IEA:UniProtKB-KW.
DR   GO; GO:0006098; P:pentose-phosphate shunt; ISS:UniProtKB.
DR   Gene3D; 1.10.1040.10; -; 1.
DR   Gene3D; 1.20.5.320; -; 1.
DR   Gene3D; 3.40.50.720; -; 1.
DR   InterPro; IPR008927; 6-PGluconate_DH_C-like.
DR   InterPro; IPR006114; 6PGDH_C.
DR   InterPro; IPR006113; 6PGDH_decarbox.
DR   InterPro; IPR006115; 6PGDH_NADP-bd.
DR   InterPro; IPR006184; 6PGdom_BS.
DR   InterPro; IPR013328; DH_multihelical.
DR   InterPro; IPR012284; Fibritin/6PGD_C-extension.
DR   InterPro; IPR016040; NAD(P)-bd_dom.
DR   Pfam; PF00393; 6PGD; 1.
DR   Pfam; PF03446; NAD_binding_2; 1.
DR   PIRSF; PIRSF000109; 6PGD; 1.
DR   SUPFAM; SSF48179; SSF48179; 1.
DR   TIGRFAMs; TIGR00873; gnd; 1.
DR   PROSITE; PS00461; 6PGD; 1.
PE   3: Inferred from homology;
KW   Complete proteome; Gluconate utilization; NADP; Oxidoreductase;
KW   Pentose shunt; Reference proteome.
FT   CHAIN         1    468       6-phosphogluconate dehydrogenase,
FT                                decarboxylating.
FT                                /FTId=PRO_0000090047.
FT   NP_BIND      10     15       NADP (By similarity).
FT   NP_BIND      33     35       NADP (By similarity).
FT   NP_BIND      74     76       NADP (By similarity).
FT   REGION      128    130       Substrate binding (By similarity).
FT   REGION      186    187       Substrate binding (By similarity).
FT   ACT_SITE    183    183       Proton acceptor (By similarity).
FT   ACT_SITE    190    190       Proton donor (By similarity).
FT   BINDING     102    102       NADP (By similarity).
FT   BINDING     102    102       Substrate (By similarity).
FT   BINDING     191    191       Substrate (By similarity).
FT   BINDING     260    260       Substrate; via amide nitrogen (By
FT                                similarity).
FT   BINDING     287    287       Substrate (By similarity).
FT   BINDING     445    445       Substrate; shared with dimeric partner
FT                                (By similarity).
FT   BINDING     451    451       Substrate; shared with dimeric partner
FT                                (By similarity).
SQ   SEQUENCE   468 AA;  51395 MW;  D8EBB53A2DAADBF7 CRC64;
     MSKQQIGVVG MAVMGRNLAL NIESRGYTVS VFNRSREKTE EVIAENPGKK LVPYYTVKEF
     VESLETPRRI LLMVKAGAGT DAAIDSLKPY LEKGDIIIDG GNTFFQDTIR RNRELSAEGF
     NFIGTGVSGG EEGALKGPSI MPGGQKDAYE LVAPILTKIA AVAEDGEPCV TYIGADGAGH
     YVKMVHNGIE YGDMQLIAEA YSLLKGGLNL SNEELANTFT EWNNGELSSY LIDITKDIFT
     KKDEDGNYLV DVILDEAANK GTGKWTSQSA LDLGEPLSLI TESVFARYIS SLKAQRVAAS
     KVLSGPKAQP AGDKAEFIEK VRRALYLGKI VSYAQGFSQL RAASDEYHWD LNYGEIAKIF
     RAGCIIRAQF LQKITDAYAE NADIANLLLA PYFKKIADEY QQALRDVVAY AVQNGIPVPT
     FSAAVAYYDS YRAAVLPANL IQAQRDYFGA HTYKRTDKEG IFHTEWLE
//
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