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Database: UniProt
Entry: P14995
LinkDB: P14995
Original site: P14995 
ID   OTC_PACTA               Reviewed;         347 AA.
AC   P14995;
DT   01-APR-1990, integrated into UniProtKB/Swiss-Prot.
DT   01-APR-1990, sequence version 1.
DT   29-OCT-2014, entry version 93.
DE   RecName: Full=Ornithine carbamoyltransferase, mitochondrial;
DE            EC=2.1.3.3;
DE   AltName: Full=Ornithine transcarbamylase;
DE            Short=OTCase;
DE   Flags: Precursor;
GN   Name=OTC;
OS   Pachysolen tannophilus (Yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina;
OC   Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Pachysolen.
OX   NCBI_TaxID=4918;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 32691 / BCRC 20329 / CBS 4044 / DSM 70352 / NBRC 1007 /
RC   NRRL Y-2460;
RX   PubMed=2327179; DOI=10.1002/yea.320060208;
RA   Skrzypek M., Borsuk P., Maleszka R.;
RT   "Cloning and sequencing of the ornithine carbamoyltransferase gene
RT   from Pachysolen tannophilus.";
RL   Yeast 6:141-148(1990).
CC   -!- CATALYTIC ACTIVITY: Carbamoyl phosphate + L-ornithine = phosphate
CC       + L-citrulline.
CC   -!- PATHWAY: Amino-acid biosynthesis; L-arginine biosynthesis; L-
CC       arginine from L-ornithine and carbamoyl phosphate: step 1/3.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion matrix.
CC   -!- SIMILARITY: Belongs to the ATCase/OTCase family. {ECO:0000305}.
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DR   EMBL; X15412; CAA33458.1; -; Genomic_DNA.
DR   PIR; S08643; OWCKPT.
DR   ProteinModelPortal; P14995; -.
DR   UniPathway; UPA00068; UER00112.
DR   GO; GO:0005739; C:mitochondrion; IEA:UniProtKB-KW.
DR   GO; GO:0016597; F:amino acid binding; IEA:InterPro.
DR   GO; GO:0004585; F:ornithine carbamoyltransferase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006526; P:arginine biosynthetic process; IEA:UniProtKB-UniPathway.
DR   Gene3D; 3.40.50.1370; -; 2.
DR   InterPro; IPR006132; Asp/Orn_carbamoyltranf_P-bd.
DR   InterPro; IPR006130; Asp/Orn_carbamoylTrfase.
DR   InterPro; IPR006131; Asp_carbamoyltransf_Asp/Orn-bd.
DR   InterPro; IPR002292; Orn/put_carbamltrans.
DR   Pfam; PF00185; OTCace; 1.
DR   Pfam; PF02729; OTCace_N; 1.
DR   PRINTS; PR00100; AOTCASE.
DR   PRINTS; PR00102; OTCASE.
DR   SUPFAM; SSF53671; SSF53671; 1.
DR   TIGRFAMs; TIGR00658; orni_carb_tr; 1.
DR   PROSITE; PS00097; CARBAMOYLTRANSFERASE; 1.
PE   3: Inferred from homology;
KW   Amino-acid biosynthesis; Arginine biosynthesis; Mitochondrion;
KW   Transferase; Transit peptide.
FT   TRANSIT       1     25       Mitochondrion.
FT   CHAIN        26    347       Ornithine carbamoyltransferase,
FT                                mitochondrial.
FT                                /FTId=PRO_0000020345.
FT   REGION       84     88       Ornithine and carbamoyl phosphate
FT                                binding. {ECO:0000250}.
FT   REGION      162    165       Ornithine and carbamoyl phosphate
FT                                binding. {ECO:0000250}.
FT   REGION      258    262       Ornithine binding. {ECO:0000250}.
FT   REGION      299    302       Ornithine binding. {ECO:0000250}.
FT   ACT_SITE    300    300       {ECO:0000250}.
FT   BINDING     135    135       Carbamoyl phosphate. {ECO:0000250}.
FT   BINDING     135    135       Ornithine. {ECO:0000250}.
FT   BINDING     162    162       Carbamoyl phosphate. {ECO:0000250}.
FT   BINDING     194    194       Ornithine. {ECO:0000250}.
FT   BINDING     328    328       Carbamoyl phosphate. {ECO:0000250}.
FT   BINDING     328    328       Ornithine. {ECO:0000250}.
SQ   SEQUENCE   347 AA;  38313 MW;  7B89324C829F7CB4 CRC64;
     MINSISNTVL LKSVVSKRFF SSSAKMSSQA KPRHLVSMLE LSIKELESLV NRAAYHKQQI
     RSGLVNTTQP LSGKTVSLIF NKRSTRTRVS SEGAAAYLGG CPMFLGKDDI QLGVNESLHD
     TTKIISSMTS SIFARVNKHS DIQEMCKYSS VPIINALCDT FHPLQAITDI LTIKESFGNT
     TKGLKLAWIG DVNNVINDLC IAALKSGIDV SIAVPSGLKF EELILSGAKE ISAENGTTLK
     ITNDPLEAIN GANVIVTDTW ISMGQEDERL QKLKQFEGFQ ITKEMISKGK AAENWKFMHC
     LPRHPEEVHD EVFYDEERSL VFEEGENRLY AAIAVLEGFV VNKGKLL
//
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