ID OTC_PACTA Reviewed; 347 AA.
AC P14995;
DT 01-APR-1990, integrated into UniProtKB/Swiss-Prot.
DT 01-APR-1990, sequence version 1.
DT 03-APR-2013, entry version 88.
DE RecName: Full=Ornithine carbamoyltransferase, mitochondrial;
DE EC=2.1.3.3;
DE AltName: Full=Ornithine transcarbamylase;
DE Short=OTCase;
DE Flags: Precursor;
GN Name=OTC;
OS Pachysolen tannophilus (Yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina;
OC Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Pachysolen.
OX NCBI_TaxID=4918;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ATCC 32691 / BCRC 20329 / CBS 4044 / DSM 70352 / NBRC 1007 /
RC NRRL Y-2460;
RX PubMed=2327179; DOI=10.1002/yea.320060208;
RA Skrzypek M., Borsuk P., Maleszka R.;
RT "Cloning and sequencing of the ornithine carbamoyltransferase gene
RT from Pachysolen tannophilus.";
RL Yeast 6:141-148(1990).
CC -!- CATALYTIC ACTIVITY: Carbamoyl phosphate + L-ornithine = phosphate
CC + L-citrulline.
CC -!- PATHWAY: Amino-acid biosynthesis; L-arginine biosynthesis; L-
CC arginine from L-ornithine and carbamoyl phosphate: step 1/3.
CC -!- SUBCELLULAR LOCATION: Mitochondrion matrix.
CC -!- SIMILARITY: Belongs to the ATCase/OTCase family.
CC -----------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution-NoDerivs License
CC -----------------------------------------------------------------------
DR EMBL; X15412; CAA33458.1; -; Genomic_DNA.
DR PIR; S08643; OWCKPT.
DR ProteinModelPortal; P14995; -.
DR UniPathway; UPA00068; UER00112.
DR GO; GO:0005759; C:mitochondrial matrix; IEA:UniProtKB-SubCell.
DR GO; GO:0016597; F:amino acid binding; IEA:InterPro.
DR GO; GO:0004585; F:ornithine carbamoyltransferase activity; IEA:EC.
DR GO; GO:0006526; P:arginine biosynthetic process; IEA:UniProtKB-UniPathway.
DR GO; GO:0006591; P:ornithine metabolic process; IEA:GOC.
DR InterPro; IPR006132; Asp/Orn_carbamoyltranf_P-bd.
DR InterPro; IPR006130; Asp/Orn_carbamoylTrfase.
DR InterPro; IPR006131; Asp_carbamoyltransf_Asp/Orn-bd.
DR InterPro; IPR002292; Orn/put_carbamltrans.
DR Pfam; PF00185; OTCace; 1.
DR Pfam; PF02729; OTCace_N; 1.
DR PRINTS; PR00100; AOTCASE.
DR PRINTS; PR00102; OTCASE.
DR SUPFAM; SSF53671; Asp/Orn_carbamoyltranf; 1.
DR TIGRFAMs; TIGR00658; orni_carb_tr; 1.
DR PROSITE; PS00097; CARBAMOYLTRANSFERASE; 1.
PE 3: Inferred from homology;
KW Amino-acid biosynthesis; Arginine biosynthesis; Mitochondrion;
KW Transferase; Transit peptide.
FT TRANSIT 1 25 Mitochondrion.
FT CHAIN 26 347 Ornithine carbamoyltransferase,
FT mitochondrial.
FT /FTId=PRO_0000020345.
FT REGION 84 88 Ornithine and carbamoyl phosphate binding
FT (By similarity).
FT REGION 162 165 Ornithine and carbamoyl phosphate binding
FT (By similarity).
FT REGION 258 262 Ornithine binding (By similarity).
FT REGION 299 302 Ornithine binding (By similarity).
FT ACT_SITE 300 300 By similarity.
FT BINDING 135 135 Carbamoyl phosphate (By similarity).
FT BINDING 135 135 Ornithine (By similarity).
FT BINDING 162 162 Carbamoyl phosphate (By similarity).
FT BINDING 194 194 Ornithine (By similarity).
FT BINDING 328 328 Carbamoyl phosphate (By similarity).
FT BINDING 328 328 Ornithine (By similarity).
SQ SEQUENCE 347 AA; 38313 MW; 7B89324C829F7CB4 CRC64;
MINSISNTVL LKSVVSKRFF SSSAKMSSQA KPRHLVSMLE LSIKELESLV NRAAYHKQQI
RSGLVNTTQP LSGKTVSLIF NKRSTRTRVS SEGAAAYLGG CPMFLGKDDI QLGVNESLHD
TTKIISSMTS SIFARVNKHS DIQEMCKYSS VPIINALCDT FHPLQAITDI LTIKESFGNT
TKGLKLAWIG DVNNVINDLC IAALKSGIDV SIAVPSGLKF EELILSGAKE ISAENGTTLK
ITNDPLEAIN GANVIVTDTW ISMGQEDERL QKLKQFEGFQ ITKEMISKGK AAENWKFMHC
LPRHPEEVHD EVFYDEERSL VFEEGENRLY AAIAVLEGFV VNKGKLL
//
