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Database: UniProt
Entry: P18506
LinkDB: P18506
Original site: P18506 
ID   GBRD_RAT                Reviewed;         449 AA.
AC   P18506;
DT   01-NOV-1990, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-1994, sequence version 2.
DT   11-JUN-2014, entry version 119.
DE   RecName: Full=Gamma-aminobutyric acid receptor subunit delta;
DE   AltName: Full=GABA(A) receptor subunit delta;
DE   Flags: Precursor;
GN   Name=Gabrd;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;
OC   Muroidea; Muridae; Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE.
RC   TISSUE=Brain;
RX   PubMed=2561970; DOI=10.1016/0896-6273(89)90257-2;
RA   Shivers B.D., Killisch I., Sprengel R., Sontheimer H., Koehler M.,
RA   Schofield P.R., Seeburg P.H.;
RT   "Two novel GABAA receptor subunits exist in distinct neuronal
RT   subpopulations.";
RL   Neuron 3:327-337(1989).
RN   [2]
RP   NUCLEOTIDE SEQUENCE.
RC   TISSUE=Brain;
RX   PubMed=1690000; DOI=10.1016/0006-291X(90)91747-G;
RA   Zhao Z.Y., Joho R.H.;
RT   "Isolation of distantly related members in a multigene family using
RT   the polymerase chain reaction technique.";
RL   Biochem. Biophys. Res. Commun. 167:174-182(1990).
RN   [3]
RP   ERRATUM.
RA   Zhao Z.Y., Joho R.H.;
RL   Biochem. Biophys. Res. Commun. 168:887-887(1990).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [5]
RP   NUCLEOTIDE SEQUENCE OF 1-22.
RC   STRAIN=Sprague-Dawley; TISSUE=Testis;
RX   PubMed=8195163;
RA   Motejlek K., Hauselmann R., Leitgeb S., Luescher B.;
RT   "BSF1, a novel brain-specific DNA-binding protein recognizing a
RT   tandemly repeated purine DNA element in the GABAA receptor delta
RT   subunit gene.";
RL   J. Biol. Chem. 269:15265-15273(1994).
CC   -!- FUNCTION: GABA, the major inhibitory neurotransmitter in the
CC       vertebrate brain, mediates neuronal inhibition by binding to the
CC       GABA/benzodiazepine receptor and opening an integral chloride
CC       channel.
CC   -!- SUBUNIT: Generally pentameric. There are five types of GABA(A)
CC       receptor chains: alpha, beta, gamma, delta, and rho.
CC   -!- SUBCELLULAR LOCATION: Cell junction, synapse, postsynaptic cell
CC       membrane; Multi-pass membrane protein. Cell membrane; Multi-pass
CC       membrane protein.
CC   -!- SIMILARITY: Belongs to the ligand-gated ion channel (TC 1.A.9)
CC       family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily.
CC       GABRD sub-subfamily.
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DR   EMBL; L08496; AAC42035.1; -; Genomic_DNA.
DR   EMBL; BC087714; AAH87714.1; -; mRNA.
DR   EMBL; M35162; AAA41182.1; -; mRNA.
DR   PIR; A34625; A34625.
DR   RefSeq; NP_058985.1; NM_017289.1.
DR   UniGene; Rn.10927; -.
DR   ProteinModelPortal; P18506; -.
DR   STRING; 10116.ENSRNOP00000022246; -.
DR   BindingDB; P18506; -.
DR   ChEMBL; CHEMBL2096683; -.
DR   GuidetoPHARMACOLOGY; 416; -.
DR   PaxDb; P18506; -.
DR   Ensembl; ENSRNOT00000022246; ENSRNOP00000022246; ENSRNOG00000016385.
DR   GeneID; 29689; -.
DR   KEGG; rno:29689; -.
DR   CTD; 2563; -.
DR   RGD; 61901; Gabrd.
DR   eggNOG; NOG308574; -.
DR   GeneTree; ENSGT00630000089571; -.
DR   HOGENOM; HOG000231335; -.
DR   HOVERGEN; HBG051707; -.
DR   InParanoid; P18506; -.
DR   KO; K05184; -.
DR   OMA; EYTMTVF; -.
DR   OrthoDB; EOG712TVZ; -.
DR   PhylomeDB; P18506; -.
DR   TreeFam; TF315453; -.
DR   NextBio; 610071; -.
DR   PRO; PR:P18506; -.
DR   Genevestigator; P18506; -.
DR   GO; GO:0030054; C:cell junction; IEA:UniProtKB-KW.
DR   GO; GO:0034707; C:chloride channel complex; IEA:UniProtKB-KW.
DR   GO; GO:0045211; C:postsynaptic membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005254; F:chloride channel activity; IEA:UniProtKB-KW.
DR   GO; GO:0005230; F:extracellular ligand-gated ion channel activity; IEA:InterPro.
DR   GO; GO:0004890; F:GABA-A receptor activity; IDA:RGD.
DR   GO; GO:0007165; P:signal transduction; IDA:GOC.
DR   GO; GO:0007268; P:synaptic transmission; IDA:RGD.
DR   Gene3D; 2.70.170.10; -; 1.
DR   InterPro; IPR006028; GABAA/Glycine_rcpt.
DR   InterPro; IPR008098; GABAAd_rcpt.
DR   InterPro; IPR006202; Neur_chan_lig-bd.
DR   InterPro; IPR006201; Neur_channel.
DR   InterPro; IPR006029; Neurotrans-gated_channel_TM.
DR   InterPro; IPR018000; Neurotransmitter_ion_chnl_CS.
DR   PANTHER; PTHR18945; PTHR18945; 1.
DR   Pfam; PF02931; Neur_chan_LBD; 1.
DR   Pfam; PF02932; Neur_chan_memb; 1.
DR   PRINTS; PR01722; GABAARDELTA.
DR   PRINTS; PR00253; GABAARECEPTR.
DR   PRINTS; PR00252; NRIONCHANNEL.
DR   SUPFAM; SSF63712; SSF63712; 1.
DR   SUPFAM; SSF90112; SSF90112; 1.
DR   TIGRFAMs; TIGR00860; LIC; 1.
DR   PROSITE; PS00236; NEUROTR_ION_CHANNEL; 1.
PE   2: Evidence at transcript level;
KW   Cell junction; Cell membrane; Chloride; Chloride channel;
KW   Complete proteome; Disulfide bond; Glycoprotein; Ion channel;
KW   Ion transport; Membrane; Postsynaptic cell membrane;
KW   Reference proteome; Signal; Synapse; Transmembrane;
KW   Transmembrane helix; Transport.
FT   SIGNAL        1     16
FT   CHAIN        17    449       Gamma-aminobutyric acid receptor subunit
FT                                delta.
FT                                /FTId=PRO_0000000470.
FT   TOPO_DOM     17    248       Extracellular (Probable).
FT   TRANSMEM    249    271       Helical; (Probable).
FT   TRANSMEM    275    297       Helical; (Probable).
FT   TRANSMEM    309    331       Helical; (Probable).
FT   TOPO_DOM    332    426       Cytoplasmic (Probable).
FT   TRANSMEM    427    449       Helical; (Probable).
FT   CARBOHYD    103    103       N-linked (GlcNAc...) (Potential).
FT   CARBOHYD    106    106       N-linked (GlcNAc...) (Potential).
FT   DISULFID    164    178       By similarity.
SQ   SEQUENCE   449 AA;  50566 MW;  64BDBCDEEB2C70AF CRC64;
     MDVLGWLLLP LLLLCTQPHH GARAMNDIGD YVGSNLEISW LPNLDGLMEG YARNFRPGIG
     GPPVNVALAL EVASIDHISE ANMEYTMTVF LHQSWRDSRL SYNHTNETLG LDSRFVDKLW
     LPDTFIVNAK SAWFHDVTVE NKLIRLQPDG VILYSIRITS TVACDMDLAK YPMDEQECML
     DLESYGYSSE DIVYYWSENQ EQIHGLDRLQ LAQFTITSYR FTTELMNFKS AGQFPRLSLH
     FQLRRNRGVY IIQSYMPSVL LVAMSWVSFW ISQAAVPARV SLGITTVLTM TTLMVSARSS
     LPRASAIKAL DVYFWICYVF VFAALVEYAF AHFNADYRKK RKAKVKVTKP RAEMDVRNAI
     VLFSLSAAGV SQELAISRRQ GRVPGNLMGS YRSVEVEAKK EGGSRPGGPG GIRSRLKPID
     ADTIDIYARA VFPAAFAAVN IIYWAAYTM
//
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