ID ACT2_ARTSX Reviewed; 376 AA.
AC P18601;
DT 01-NOV-1990, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1990, sequence version 1.
DT 03-APR-2013, entry version 67.
DE RecName: Full=Actin, clone 211;
DE Flags: Precursor;
OS Artemia sp. (Brine shrimp).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Crustacea; Branchiopoda;
OC Anostraca; Artemiidae; Artemia.
OX NCBI_TaxID=6662;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=2402445; DOI=10.1093/nar/18.17.5219;
RA Macias M.-T., Sastre L.;
RT "Molecular cloning and expression of four actin isoforms during
RT Artemia development.";
RL Nucleic Acids Res. 18:5219-5225(1990).
CC -!- FUNCTION: Actins are highly conserved proteins that are involved
CC in various types of cell motility and are ubiquitously expressed
CC in all eukaryotic cells.
CC -!- FUNCTION: Multiple isoforms are involved in various cellular
CC functions such as cytoskeleton structure, cell mobility,
CC chromosome movement and muscle contraction.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton.
CC -!- PTM: Oxidation of Met-45 to form methionine sulfoxide promotes
CC actin filament depolymerization. Methionine sulfoxide is produced
CC stereospecifically, but it is not known whether the (S)-S-oxide or
CC the (R)-S-oxide is produced (By similarity).
CC -!- MISCELLANEOUS: There are at least 4 actin isoforms expressed
CC during artemia development.
CC -!- SIMILARITY: Belongs to the actin family.
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DR EMBL; X52603; CAA36836.1; -; mRNA.
DR PIR; S11451; S11451.
DR ProteinModelPortal; P18601; -.
DR SMR; P18601; 3-376.
DR PRIDE; P18601; -.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR InterPro; IPR004000; Actin-related.
DR InterPro; IPR020902; Actin/actin-like_CS.
DR InterPro; IPR004001; Actin_CS.
DR PANTHER; PTHR11937; PTHR11937; 1.
DR Pfam; PF00022; Actin; 1.
DR PRINTS; PR00190; ACTIN.
DR SMART; SM00268; ACTIN; 1.
DR PROSITE; PS00406; ACTINS_1; 1.
DR PROSITE; PS00432; ACTINS_2; 1.
DR PROSITE; PS01132; ACTINS_ACT_LIKE; 1.
PE 2: Evidence at transcript level;
KW Acetylation; ATP-binding; Cytoplasm; Cytoskeleton; Nucleotide-binding;
KW Oxidation.
FT PROPEP 1 2 Removed in mature form (By similarity).
FT /FTId=PRO_0000000612.
FT CHAIN 3 376 Actin, clone 211.
FT /FTId=PRO_0000000613.
FT MOD_RES 3 3 N-acetylaspartate (By similarity).
FT MOD_RES 45 45 Methionine sulfoxide (By similarity).
FT MOD_RES 48 48 Methionine sulfoxide (By similarity).
SQ SEQUENCE 376 AA; 41784 MW; 7EF88D8ADF3BD19B CRC64;
MCDDDVAALV VDNGSGMCKA GFAGDDAPRA VFPSIVGRPR HQGVMVGMGQ KDSYVGDEAQ
SKRGILTLKY PIEHGIITNW DDMEKIWHHT FYNELRVAPE EHPILLTEAP LNPKANREKM
TQIMFETFNS PAMYVAIQAV LSIYASGRTT GIVLDSGDGV SHTVPIYEGY ALPHAILRLD
LAGRDLIDYL MKILTERGYS FTTTAEREIV RDIKEKLCYV ALDFEQEMAT AAASTSLEKS
YELPDGQVIT IGNERFRCPE ALFQPSFLGM ESCGIHETVY NSIMKCDVDI RKDLYANTVL
SGGTTMYPGI ADRMQKEITA LAPSTIKIKI IAPPERKYSV WIGGSILASL STFQQMWISK
QEYDESGPGI VHRKCF
//
