ID HXD3_RAT Reviewed; 114 AA.
AC P18867;
DT 01-NOV-1990, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1990, sequence version 1.
DT 08-NOV-2023, entry version 127.
DE RecName: Full=Homeobox protein Hox-D3;
DE AltName: Full=Homeobox protein R6;
DE Flags: Fragment;
GN Name=Hoxd3; Synonyms=Hoxd-3;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=Sprague-Dawley;
RX PubMed=2907739; DOI=10.1242/dev.103.3.601;
RA Falzon M., Chung S.Y.;
RT "The expression of rat homeobox-containing genes is developmentally
RT regulated and tissue specific.";
RL Development 103:601-610(1988).
CC -!- FUNCTION: Sequence-specific transcription factor which is part of a
CC developmental regulatory system that provides cells with specific
CC positional identities on the anterior-posterior axis.
CC -!- SUBCELLULAR LOCATION: Nucleus.
CC -!- TISSUE SPECIFICITY: Predominantly spinal cord and kidney.
CC -!- SIMILARITY: Belongs to the Antp homeobox family. {ECO:0000305}.
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DR EMBL; M37569; AAA41345.1; -; mRNA.
DR PIR; E43559; E43559.
DR AlphaFoldDB; P18867; -.
DR SMR; P18867; -.
DR STRING; 10116.ENSRNOP00000034938; -.
DR PaxDb; 10116-ENSRNOP00000034938; -.
DR UCSC; RGD:1588601; rat.
DR AGR; RGD:1588601; -.
DR RGD; 1588601; Hoxd3.
DR eggNOG; KOG0489; Eukaryota.
DR InParanoid; P18867; -.
DR Proteomes; UP000002494; Unplaced.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; ISO:RGD.
DR GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; ISO:RGD.
DR GO; GO:1990837; F:sequence-specific double-stranded DNA binding; ISO:RGD.
DR GO; GO:0009952; P:anterior/posterior pattern specification; ISO:RGD.
DR GO; GO:0051216; P:cartilage development; ISO:RGD.
DR GO; GO:0007160; P:cell-matrix adhesion; ISO:RGD.
DR GO; GO:0006351; P:DNA-templated transcription; ISO:RGD.
DR GO; GO:0048704; P:embryonic skeletal system morphogenesis; ISO:RGD.
DR GO; GO:0021615; P:glossopharyngeal nerve morphogenesis; ISO:RGD.
DR GO; GO:0007219; P:Notch signaling pathway; ISO:RGD.
DR GO; GO:0010628; P:positive regulation of gene expression; ISO:RGD.
DR GO; GO:0045666; P:positive regulation of neuron differentiation; ISO:RGD.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; ISO:RGD.
DR GO; GO:0030878; P:thyroid gland development; ISO:RGD.
DR CDD; cd00086; homeodomain; 1.
DR Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR020479; Homeobox_metazoa.
DR PANTHER; PTHR45664:SF5; HOMEOBOX PROTEIN HOX-D3; 1.
DR PANTHER; PTHR45664; PROTEIN ZERKNUELLT 1-RELATED; 1.
DR Pfam; PF00046; Homeodomain; 1.
DR PRINTS; PR00024; HOMEOBOX.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; Homeodomain-like; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 2: Evidence at transcript level;
KW Developmental protein; DNA-binding; Homeobox; Nucleus; Reference proteome;
KW Transcription; Transcription regulation.
FT CHAIN <1..>114
FT /note="Homeobox protein Hox-D3"
FT /id="PRO_0000200206"
FT DNA_BIND 11..70
FT /note="Homeobox"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT REGION 70..93
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT NON_TER 114
SQ SEQUENCE 114 AA; 13044 MW; C4192BE1F2C7F591 CRC64;
TGRTRAHRAR HPRGCTAYTS AQLVELEKEF HFNRYLCRRR RVEMANLLNL TERQIKIWFQ
NRRMKYKKDQ KAKGILHSPA GQSPERTPPL GGAAATCLLR PAAAVPAWPT THPS
//
