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Database: UniProt
Entry: P19019
LinkDB: P19019
Original site: P19019 
ID   GBRB3_CHICK             Reviewed;         476 AA.
AC   P19019;
DT   01-NOV-1990, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1990, sequence version 1.
DT   29-OCT-2014, entry version 112.
DE   RecName: Full=Gamma-aminobutyric acid receptor subunit beta-3;
DE   AltName: Full=GABA(A) receptor subunit beta-3;
DE   Flags: Precursor;
GN   Name=GABRB3;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Testudines + Archosauria group; Archosauria; Dinosauria; Saurischia;
OC   Theropoda; Coelurosauria; Aves; Neognathae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=Commercial Rhode Island cross; TISSUE=Brain;
RX   PubMed=2170940; DOI=10.1093/nar/18.18.5557;
RA   Bateson A.N., Harvey R.J., Blocks C.C.M., Darlison M.G.;
RT   "Sequence of the chicken GABAA receptor beta 3-subunit cDNA.";
RL   Nucleic Acids Res. 18:5557-5557(1990).
CC   -!- FUNCTION: GABA, the major inhibitory neurotransmitter in the
CC       vertebrate brain, mediates neuronal inhibition by binding to the
CC       GABA/benzodiazepine receptor and opening an integral chloride
CC       channel.
CC   -!- SUBUNIT: Generally pentameric. There are five types of GABA(A)
CC       receptor chains: alpha, beta, gamma, delta, and rho.
CC   -!- SUBCELLULAR LOCATION: Cell junction, synapse, postsynaptic cell
CC       membrane; Multi-pass membrane protein. Cell membrane; Multi-pass
CC       membrane protein.
CC   -!- SIMILARITY: Belongs to the ligand-gated ion channel (TC 1.A.9)
CC       family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily.
CC       GABRB3 sub-subfamily. {ECO:0000305}.
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DR   EMBL; X54243; CAA38147.1; -; mRNA.
DR   PIR; S11440; S11440.
DR   RefSeq; NP_990677.1; NM_205346.3.
DR   UniGene; Gga.747; -.
DR   ProteinModelPortal; P19019; -.
DR   SMR; P19019; 274-330.
DR   STRING; 9031.ENSGALP00000026978; -.
DR   PaxDb; P19019; -.
DR   Ensembl; ENSGALT00000027028; ENSGALP00000026977; ENSGALG00000016745.
DR   GeneID; 396290; -.
DR   KEGG; gga:396290; -.
DR   CTD; 2562; -.
DR   eggNOG; NOG77438; -.
DR   GeneTree; ENSGT00760000118821; -.
DR   HOGENOM; HOG000231335; -.
DR   HOVERGEN; HBG051707; -.
DR   InParanoid; P19019; -.
DR   KO; K05181; -.
DR   PhylomeDB; P19019; -.
DR   Reactome; REACT_197080; GABA A receptor activation.
DR   Reactome; REACT_197085; Ligand-gated ion channel transport.
DR   NextBio; 20816341; -.
DR   PRO; PR:P19019; -.
DR   GO; GO:0030054; C:cell junction; IEA:UniProtKB-KW.
DR   GO; GO:0034707; C:chloride channel complex; IEA:UniProtKB-KW.
DR   GO; GO:0045211; C:postsynaptic membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005254; F:chloride channel activity; IEA:UniProtKB-KW.
DR   GO; GO:0005230; F:extracellular ligand-gated ion channel activity; IEA:InterPro.
DR   GO; GO:0004890; F:GABA-A receptor activity; IEA:InterPro.
DR   GO; GO:0090102; P:cochlea development; IEA:Ensembl.
DR   GO; GO:0060119; P:inner ear receptor cell development; IEA:Ensembl.
DR   GO; GO:0060384; P:innervation; IEA:Ensembl.
DR   GO; GO:0043524; P:negative regulation of neuron apoptotic process; IEA:Ensembl.
DR   GO; GO:0007605; P:sensory perception of sound; IEA:Ensembl.
DR   Gene3D; 2.70.170.10; -; 1.
DR   InterPro; IPR006028; GABAA/Glycine_rcpt.
DR   InterPro; IPR002289; GABAAb_rcpt.
DR   InterPro; IPR006202; Neur_chan_lig-bd.
DR   InterPro; IPR006201; Neur_channel.
DR   InterPro; IPR006029; Neurotrans-gated_channel_TM.
DR   InterPro; IPR018000; Neurotransmitter_ion_chnl_CS.
DR   PANTHER; PTHR18945; PTHR18945; 1.
DR   Pfam; PF02931; Neur_chan_LBD; 1.
DR   Pfam; PF02932; Neur_chan_memb; 1.
DR   PRINTS; PR01160; GABAARBETA.
DR   PRINTS; PR00253; GABAARECEPTR.
DR   PRINTS; PR00252; NRIONCHANNEL.
DR   SUPFAM; SSF63712; SSF63712; 1.
DR   SUPFAM; SSF90112; SSF90112; 1.
DR   TIGRFAMs; TIGR00860; LIC; 1.
DR   PROSITE; PS00236; NEUROTR_ION_CHANNEL; 1.
PE   2: Evidence at transcript level;
KW   Cell junction; Cell membrane; Chloride; Chloride channel;
KW   Complete proteome; Disulfide bond; Glycoprotein; Ion channel;
KW   Ion transport; Ligand-gated ion channel; Membrane;
KW   Postsynaptic cell membrane; Receptor; Reference proteome; Signal;
KW   Synapse; Transmembrane; Transmembrane helix; Transport.
FT   SIGNAL        1     25       {ECO:0000255}.
FT   CHAIN        26    476       Gamma-aminobutyric acid receptor subunit
FT                                beta-3.
FT                                /FTId=PRO_0000000465.
FT   TOPO_DOM     26    245       Extracellular. {ECO:0000305}.
FT   TRANSMEM    246    267       Helical. {ECO:0000305}.
FT   TRANSMEM    271    293       Helical. {ECO:0000305}.
FT   TRANSMEM    305    327       Helical. {ECO:0000305}.
FT   TOPO_DOM    328    453       Cytoplasmic. {ECO:0000305}.
FT   TRANSMEM    454    475       Helical. {ECO:0000305}.
FT   CARBOHYD     33     33       N-linked (GlcNAc...). {ECO:0000255}.
FT   CARBOHYD    105    105       N-linked (GlcNAc...). {ECO:0000255}.
FT   CARBOHYD    174    174       N-linked (GlcNAc...). {ECO:0000255}.
FT   DISULFID    161    175       {ECO:0000250}.
SQ   SEQUENCE   476 AA;  54433 MW;  8DD0AB7CF7BB3698 CRC64;
     MWGFGGGRIF GIFSAPVLVA VVCCAQSVND PGNMSFVKET VDKLLKGYDI RLRPDFGGPP
     VCVGMNIDIA SIDMVSEVNM DYTLTMYFQQ YWRDKRLAYA GIPLNLTLDN RVADQLWVPD
     TYFLNDKKSF VHGVTVKNRM IRLHPDGTVL YGLRITTTAA CMMDLRRYPL DEQNCTLEIE
     SYGYTTDDIE FYWRGGDNAV TGVERIELPQ FSIVEYRLVS KNVVFATGAY PRLSLSFRLK
     RNIGYFILQT YMPSILITIL SWVSFWINYD ASAARVALGI TTVLTMTTIN THLRETLPKI
     PYVKAIDMYL MGCFVFVFLA LLEYAFVNYI FFGKGPQRQK KLAEKSAKAN NDRSRFEGSR
     VDTHGNILLT SLEIHNEVAS NEVTTSVTDA RNSTISFDNS GIQYRKQSSH RESLGRRSSD
     RTGSHSKRGH LRRRSSQLKI KIPDLTDVNA IDRWSRMVFP FTFSLFNLIY WLYYVN
//
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