ID GBRB3_CHICK Reviewed; 476 AA.
AC P19019;
DT 01-NOV-1990, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1990, sequence version 1.
DT 03-APR-2013, entry version 100.
DE RecName: Full=Gamma-aminobutyric acid receptor subunit beta-3;
DE AltName: Full=GABA(A) receptor subunit beta-3;
DE Flags: Precursor;
GN Name=GABRB3;
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves;
OC Neognathae; Galliformes; Phasianidae; Phasianinae; Gallus.
OX NCBI_TaxID=9031;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=Commercial Rhode Island cross; TISSUE=Brain;
RX PubMed=2170940; DOI=10.1093/nar/18.18.5557;
RA Bateson A.N., Harvey R.J., Blocks C.C.M., Darlison M.G.;
RT "Sequence of the chicken GABAA receptor beta 3-subunit cDNA.";
RL Nucleic Acids Res. 18:5557-5557(1990).
CC -!- FUNCTION: GABA, the major inhibitory neurotransmitter in the
CC vertebrate brain, mediates neuronal inhibition by binding to the
CC GABA/benzodiazepine receptor and opening an integral chloride
CC channel.
CC -!- SUBUNIT: Generally pentameric. There are five types of GABA(A)
CC receptor chains: alpha, beta, gamma, delta, and rho.
CC -!- SUBCELLULAR LOCATION: Cell junction, synapse, postsynaptic cell
CC membrane; Multi-pass membrane protein. Cell membrane; Multi-pass
CC membrane protein.
CC -!- SIMILARITY: Belongs to the ligand-gated ion channel (TC 1.A.9)
CC family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily.
CC GABRB3 sub-subfamily.
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DR EMBL; X54243; CAA38147.1; -; mRNA.
DR IPI; IPI00591128; -.
DR PIR; S11440; S11440.
DR RefSeq; NP_990677.1; NM_205346.2.
DR UniGene; Gga.747; -.
DR ProteinModelPortal; P19019; -.
DR SMR; P19019; 274-330.
DR STRING; 9031.ENSGALP00000026978; -.
DR PaxDb; P19019; -.
DR GeneID; 396290; -.
DR KEGG; gga:396290; -.
DR CTD; 2562; -.
DR eggNOG; NOG77438; -.
DR HOGENOM; HOG000231335; -.
DR HOVERGEN; HBG051707; -.
DR InParanoid; P19019; -.
DR KO; K05181; -.
DR OrthoDB; EOG45756F; -.
DR NextBio; 20816341; -.
DR ArrayExpress; P19019; -.
DR GO; GO:0030054; C:cell junction; IEA:UniProtKB-KW.
DR GO; GO:0034707; C:chloride channel complex; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0045211; C:postsynaptic membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005254; F:chloride channel activity; IEA:UniProtKB-KW.
DR GO; GO:0005230; F:extracellular ligand-gated ion channel activity; IEA:InterPro.
DR GO; GO:0004890; F:GABA-A receptor activity; IEA:InterPro.
DR GO; GO:0090102; P:cochlea development; IEA:Compara.
DR GO; GO:0060119; P:inner ear receptor cell development; IEA:Compara.
DR GO; GO:0060384; P:innervation; IEA:Compara.
DR GO; GO:0007605; P:sensory perception of sound; IEA:Compara.
DR Gene3D; 2.70.170.10; -; 1.
DR InterPro; IPR006028; GABAA_rcpt.
DR InterPro; IPR002289; GABAAb_rcpt.
DR InterPro; IPR006202; Neur_chan_lig-bd.
DR InterPro; IPR006201; Neur_channel.
DR InterPro; IPR006029; Neurotrans-gated_channel_TM.
DR InterPro; IPR018000; Neurotransmitter_ion_chnl_CS.
DR PANTHER; PTHR18945; PTHR18945; 1.
DR Pfam; PF02931; Neur_chan_LBD; 1.
DR Pfam; PF02932; Neur_chan_memb; 1.
DR PRINTS; PR01160; GABAARBETA.
DR PRINTS; PR00253; GABAARECEPTR.
DR PRINTS; PR00252; NRIONCHANNEL.
DR SUPFAM; SSF90112; Neu_channel_TM; 1.
DR SUPFAM; SSF63712; Neur_chan_LBD; 1.
DR TIGRFAMs; TIGR00860; LIC; 1.
DR PROSITE; PS00236; NEUROTR_ION_CHANNEL; 1.
PE 2: Evidence at transcript level;
KW Cell junction; Cell membrane; Chloride; Chloride channel;
KW Complete proteome; Disulfide bond; Glycoprotein; Ion channel;
KW Ion transport; Ligand-gated ion channel; Membrane;
KW Postsynaptic cell membrane; Receptor; Reference proteome; Signal;
KW Synapse; Transmembrane; Transmembrane helix; Transport.
FT SIGNAL 1 25 Potential.
FT CHAIN 26 476 Gamma-aminobutyric acid receptor subunit
FT beta-3.
FT /FTId=PRO_0000000465.
FT TOPO_DOM 26 245 Extracellular (Probable).
FT TRANSMEM 246 267 Helical; (Probable).
FT TRANSMEM 271 293 Helical; (Probable).
FT TRANSMEM 305 327 Helical; (Probable).
FT TOPO_DOM 328 453 Cytoplasmic (Probable).
FT TRANSMEM 454 475 Helical; (Probable).
FT CARBOHYD 33 33 N-linked (GlcNAc...) (Potential).
FT CARBOHYD 105 105 N-linked (GlcNAc...) (Potential).
FT CARBOHYD 174 174 N-linked (GlcNAc...) (Potential).
FT DISULFID 161 175 By similarity.
SQ SEQUENCE 476 AA; 54433 MW; 8DD0AB7CF7BB3698 CRC64;
MWGFGGGRIF GIFSAPVLVA VVCCAQSVND PGNMSFVKET VDKLLKGYDI RLRPDFGGPP
VCVGMNIDIA SIDMVSEVNM DYTLTMYFQQ YWRDKRLAYA GIPLNLTLDN RVADQLWVPD
TYFLNDKKSF VHGVTVKNRM IRLHPDGTVL YGLRITTTAA CMMDLRRYPL DEQNCTLEIE
SYGYTTDDIE FYWRGGDNAV TGVERIELPQ FSIVEYRLVS KNVVFATGAY PRLSLSFRLK
RNIGYFILQT YMPSILITIL SWVSFWINYD ASAARVALGI TTVLTMTTIN THLRETLPKI
PYVKAIDMYL MGCFVFVFLA LLEYAFVNYI FFGKGPQRQK KLAEKSAKAN NDRSRFEGSR
VDTHGNILLT SLEIHNEVAS NEVTTSVTDA RNSTISFDNS GIQYRKQSSH RESLGRRSSD
RTGSHSKRGH LRRRSSQLKI KIPDLTDVNA IDRWSRMVFP FTFSLFNLIY WLYYVN
//
