ID MLR2_CAEEL Reviewed; 170 AA.
AC P19626;
DT 01-FEB-1991, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1991, sequence version 1.
DT 27-MAR-2024, entry version 169.
DE RecName: Full=Myosin regulatory light chain 2;
GN Name=mlc-2; ORFNames=C36E6.5;
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=3244358; DOI=10.1128/mcb.8.12.5339-5349.1988;
RA Cummins C., Anderson P.;
RT "Regulatory myosin light-chain genes of Caenorhabditis elegans.";
RL Mol. Cell. Biol. 8:5339-5349(1988).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
CC -!- SUBUNIT: Myosin is a hexamer of 2 heavy chains and 4 light chains (two
CC regulatory light chains and two essential light chains).
CC -!- MISCELLANEOUS: This chain binds calcium.
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DR EMBL; M23366; AAA28114.1; -; Genomic_DNA.
DR EMBL; FO080802; CCD66902.1; -; Genomic_DNA.
DR PIR; B31377; B31377.
DR RefSeq; NP_510828.1; NM_078427.5.
DR AlphaFoldDB; P19626; -.
DR SMR; P19626; -.
DR BioGRID; 46650; 14.
DR DIP; DIP-24755N; -.
DR IntAct; P19626; 1.
DR STRING; 6239.C36E6.5.1; -.
DR World-2DPAGE; 0020:P19626; -.
DR EPD; P19626; -.
DR PaxDb; 6239-C36E6-5; -.
DR PeptideAtlas; P19626; -.
DR EnsemblMetazoa; C36E6.5.1; C36E6.5.1; WBGene00003370.
DR GeneID; 181775; -.
DR KEGG; cel:CELE_C36E6.5; -.
DR UCSC; C36E6.5.1; c. elegans.
DR AGR; WB:WBGene00003370; -.
DR WormBase; C36E6.5; CE20542; WBGene00003370; mlc-2.
DR eggNOG; KOG0031; Eukaryota.
DR GeneTree; ENSGT00970000196646; -.
DR HOGENOM; CLU_061288_9_3_1; -.
DR InParanoid; P19626; -.
DR OMA; VIMGAFK; -.
DR OrthoDB; 312751at2759; -.
DR PhylomeDB; P19626; -.
DR Reactome; R-CEL-390522; Striated Muscle Contraction.
DR Reactome; R-CEL-445355; Smooth Muscle Contraction.
DR Reactome; R-CEL-5627123; RHO GTPases activate PAKs.
DR SignaLink; P19626; -.
DR PRO; PR:P19626; -.
DR Proteomes; UP000001940; Chromosome X.
DR Bgee; WBGene00003370; Expressed in larva and 10 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0016460; C:myosin II complex; IBA:GO_Central.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0032036; F:myosin heavy chain binding; IBA:GO_Central.
DR GO; GO:0040011; P:locomotion; IGI:WormBase.
DR GO; GO:0002119; P:nematode larval development; IMP:WormBase.
DR GO; GO:0009791; P:post-embryonic development; IBA:GO_Central.
DR GO; GO:0006937; P:regulation of muscle contraction; IGI:WormBase.
DR GO; GO:0043051; P:regulation of nematode pharyngeal pumping; IMP:WormBase.
DR CDD; cd00051; EFh; 1.
DR Gene3D; 1.10.238.10; EF-hand; 2.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR InterPro; IPR002048; EF_hand_dom.
DR PANTHER; PTHR23049:SF7; MYOSIN REGULATORY LIGHT CHAIN 1-RELATED; 1.
DR PANTHER; PTHR23049; MYOSIN REGULATORY LIGHT CHAIN 2; 1.
DR Pfam; PF13405; EF-hand_6; 1.
DR SMART; SM00054; EFh; 2.
DR SUPFAM; SSF47473; EF-hand; 1.
DR PROSITE; PS00018; EF_HAND_1; 1.
DR PROSITE; PS50222; EF_HAND_2; 2.
PE 4: Predicted;
KW Calcium; Metal-binding; Motor protein; Myosin; Reference proteome; Repeat.
FT CHAIN 1..170
FT /note="Myosin regulatory light chain 2"
FT /id="PRO_0000198761"
FT DOMAIN 24..59
FT /note="EF-hand 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT DOMAIN 93..128
FT /note="EF-hand 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT REGION 1..22
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 37
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 39
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 41
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 48
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
SQ SEQUENCE 170 AA; 18603 MW; 66D3FEC68660DF38 CRC64;
MSKAAKKKSS KKRSGSEAAQ FDQKTIQEFK EAFGIMDQNK DGIIDKSDLK DLYASMGQIA
PDSQIDAMIK EASGPINFTV FLTLFGERLT GTDPEATIVG AFAMFDKKDC GKIKEDDLIK
ILQNKRGEPL DEDEVKAMYK GKPPIEGGEV DYKAFAHLIT TGAQDELASA
//
