ID LIGC_TRAVE Reviewed; 372 AA.
AC P20013;
DT 01-FEB-1991, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-1994, sequence version 2.
DT 03-APR-2013, entry version 81.
DE RecName: Full=Ligninase C;
DE EC=1.11.1.14;
DE AltName: Full=Diarylpropane peroxidase;
DE AltName: Full=Lignin peroxidase;
DE Flags: Precursor;
OS Trametes versicolor (White-rot fungus) (Coriolus versicolor).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina;
OC Agaricomycetes; Polyporales; Trametes.
OX NCBI_TaxID=5325;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=PRL 572;
RX PubMed=1581393; DOI=10.1016/0300-9084(92)90043-E;
RA Joensson L.J., Nyman P.O.;
RT "Characterization of a lignin peroxidase gene from the white-rot
RT fungus Trametes versicolor.";
RL Biochimie 74:177-182(1992).
RN [2]
RP PROTEIN SEQUENCE OF 27-38.
RX PubMed=2707445; DOI=10.1016/0014-5793(89)81258-X;
RA Joensson L.J., Karlsson O., Lundquist K., Nyman P.O.;
RT "Trametes versicolor ligninase: isozyme sequence homology and
RT substrate specificity.";
RL FEBS Lett. 247:143-146(1989).
CC -!- FUNCTION: Depolymerization of lignin. Catalyzes the C(alpha)-
CC C(beta) cleavage of the propyl side chains of lignin.
CC -!- CATALYTIC ACTIVITY: (3,4-dimethoxyphenyl)methanol + H(2)O(2) =
CC 3,4-dimethoxybenzaldehyde + 2 H(2)O.
CC -!- COFACTOR: Binds 2 calcium ions per subunit (By similarity).
CC -!- PATHWAY: Secondary metabolite metabolism; lignin degradation.
CC -!- DEVELOPMENTAL STAGE: Ligninases are expressed during secondary
CC metabolism, and are triggered by nutrient limitation.
CC -!- SIMILARITY: Belongs to the peroxidase family. Ligninase subfamily.
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DR EMBL; M64993; AAA34049.1; -; Genomic_DNA.
DR PIR; S32581; S32581.
DR ProteinModelPortal; P20013; -.
DR mycoCLAP; LPOC_TRAVE; -.
DR PeroxiBase; 2420; TvLiP12_PRL572.
DR UniPathway; UPA00892; -.
DR GO; GO:0016690; F:diarylpropane peroxidase activity; IEA:EC.
DR GO; GO:0020037; F:heme binding; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0042744; P:hydrogen peroxide catabolic process; IEA:UniProtKB-KW.
DR GO; GO:0046274; P:lignin catabolic process; IEA:UniProtKB-UniPathway.
DR InterPro; IPR010255; Haem_peroxidase.
DR InterPro; IPR002016; Haem_peroxidase_pln/fun/bac.
DR InterPro; IPR001621; Ligninase.
DR InterPro; IPR024589; Ligninase_C.
DR InterPro; IPR019794; Peroxidases_AS.
DR Pfam; PF11895; DUF3415; 1.
DR Pfam; PF00141; peroxidase; 1.
DR PRINTS; PR00462; LIGNINASE.
DR PRINTS; PR00458; PEROXIDASE.
DR SUPFAM; SSF48113; Peroxidase_super; 1.
DR PROSITE; PS00435; PEROXIDASE_1; FALSE_NEG.
DR PROSITE; PS00436; PEROXIDASE_2; 1.
DR PROSITE; PS50873; PEROXIDASE_4; 1.
PE 1: Evidence at protein level;
KW Calcium; Direct protein sequencing; Glycoprotein; Heme;
KW Hydrogen peroxide; Iron; Lignin degradation; Metal-binding;
KW Oxidoreductase; Peroxidase; Signal.
FT SIGNAL 1 26
FT CHAIN 27 372 Ligninase C.
FT /FTId=PRO_0000023777.
FT ACT_SITE 74 74 Proton acceptor (By similarity).
FT METAL 75 75 Calcium 1 (By similarity).
FT METAL 93 93 Calcium 1; via carbonyl oxygen (By
FT similarity).
FT METAL 95 95 Calcium 1 (By similarity).
FT METAL 97 97 Calcium 1 (By similarity).
FT METAL 205 205 Iron (heme axial ligand) (By similarity).
FT METAL 206 206 Calcium 2 (By similarity).
FT METAL 223 223 Calcium 2 (By similarity).
FT METAL 225 225 Calcium 2 (By similarity).
FT METAL 228 228 Calcium 2; via carbonyl oxygen (By
FT similarity).
FT METAL 230 230 Calcium 2 (By similarity).
FT SITE 70 70 Transition state stabilizer (By
FT similarity).
FT CARBOHYD 129 129 N-linked (GlcNAc...) (Potential).
SQ SEQUENCE 372 AA; 39625 MW; 9F7A06AABAA9B25A CRC64;
MAFKSLLSFV SVIGALQGAN AALTRRVACP DGVNTATNAA CCQLFAVRED LQQNLFHGGL
CTAEAHESLR LTFHDAIAIS PALEAQGIFG GGGADGSIAI FPEIETNFHP NIGLDEIIEL
QKPFIARHNI SVADFIQFAG AIGASNCAGA PQLAAFVGRK DATQPAPDGL VPEPFHTPDQ
IFDRLADASQ GEFDPILTVW LLTAHTVAAA NDVDPTKSGL PFDSTPELWD TQFFLETQLR
GTSFPGSGGN QGEVESPLAG EMRLQSDHTI ARDSRTACEW QSFVDNQPKA QQMFQFVFHD
LSIFGQDINT LVDCTEVVPI PADPQGHTHF PAGLSNADIE QACAETPFPT FPTDPGPKTA
VAPVPKPPAA RK
//
