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Database: UniProt
Entry: P23683
LinkDB: P23683
Original site: P23683 
ID   EVX1_MOUSE              Reviewed;         416 AA.
AC   P23683;
DT   01-NOV-1991, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1991, sequence version 1.
DT   09-JUL-2014, entry version 111.
DE   RecName: Full=Homeobox even-skipped homolog protein 1;
DE   AltName: Full=EVX-1;
GN   Name=Evx1;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;
OC   Muroidea; Muridae; Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=BALB/c; TISSUE=Liver;
RX   PubMed=1971786;
RA   Bastian H., Gruss P.;
RT   "A murine even-skipped homologue, Evx 1, is expressed during early
RT   embryogenesis and neurogenesis in a biphasic manner.";
RL   EMBO J. 9:1839-1852(1990).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=BALB/c;
RX   PubMed=1349539; DOI=10.1016/0012-1606(92)90232-6;
RA   Dush M.K., Martin G.R.;
RT   "Analysis of mouse Evx genes: Evx-1 displays graded expression in the
RT   primitive streak.";
RL   Dev. Biol. 151:273-287(1992).
CC   -!- FUNCTION: May play a role in the specification of neuronal cell
CC       types. May play a role in the dorsoventral specification of
CC       mesodermal cell fate.
CC   -!- SUBCELLULAR LOCATION: Nucleus.
CC   -!- DEVELOPMENTAL STAGE: Shows a graded distribution in the primitive
CC       streak and in cells lateral to it. It is not detected in cells
CC       along the A-P axis of the embryo anterior to the primitive streak,
CC       except at E7.5 when there is transient expression in the head
CC       process. The highest levels of expression are found within the
CC       proximal (posterior) portion of the primitive streak and cells
CC       near it, with expression levels decreasing more distally
CC       (anteriorly).
CC   -!- SIMILARITY: Belongs to the even-skipped homeobox family.
CC   -!- SIMILARITY: Contains 1 homeobox DNA-binding domain.
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DR   EMBL; X54239; CAA38145.1; -; mRNA.
DR   CCDS; CCDS20149.1; -.
DR   RefSeq; NP_031992.1; NM_007966.4.
DR   UniGene; Mm.389754; -.
DR   ProteinModelPortal; P23683; -.
DR   SMR; P23683; 185-241.
DR   STRING; 10090.ENSMUSP00000031787; -.
DR   PRIDE; P23683; -.
DR   Ensembl; ENSMUST00000031787; ENSMUSP00000031787; ENSMUSG00000005503.
DR   GeneID; 14028; -.
DR   KEGG; mmu:14028; -.
DR   UCSC; uc009byv.1; mouse.
DR   CTD; 2128; -.
DR   MGI; MGI:95461; Evx1.
DR   eggNOG; NOG298527; -.
DR   GeneTree; ENSGT00750000117293; -.
DR   HOGENOM; HOG000231897; -.
DR   HOVERGEN; HBG005620; -.
DR   InParanoid; P23683; -.
DR   KO; K09320; -.
DR   OMA; HMGLGAT; -.
DR   OrthoDB; EOG7M98GX; -.
DR   PhylomeDB; P23683; -.
DR   TreeFam; TF315938; -.
DR   NextBio; 284956; -.
DR   PRO; PR:P23683; -.
DR   Bgee; P23683; -.
DR   CleanEx; MM_EVX1; -.
DR   Genevestigator; P23683; -.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR   GO; GO:0003700; F:sequence-specific DNA binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0009792; P:embryo development ending in birth or egg hatching; IMP:MGI.
DR   GO; GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IDA:MGI.
DR   GO; GO:0021913; P:regulation of transcription from RNA polymerase II promoter involved in ventral spinal cord interneuron specification; IMP:MGI.
DR   Gene3D; 1.10.10.60; -; 1.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR020479; Homeobox_metazoa.
DR   InterPro; IPR009057; Homeodomain-like.
DR   Pfam; PF00046; Homeobox; 1.
DR   PRINTS; PR00024; HOMEOBOX.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
PE   2: Evidence at transcript level;
KW   Complete proteome; Developmental protein; DNA-binding; Homeobox;
KW   Nucleus; Reference proteome.
FT   CHAIN         1    416       Homeobox even-skipped homolog protein 1.
FT                                /FTId=PRO_0000048871.
FT   DNA_BIND    183    242       Homeobox.
FT   COMPBIAS    114    124       Asp/Glu-rich (acidic).
FT   COMPBIAS    289    297       Ala-rich.
FT   COMPBIAS    341    349       Ala-rich.
FT   COMPBIAS    369    375       Ala-rich.
SQ   SEQUENCE   416 AA;  43198 MW;  9F0EE4F3677CD3EE CRC64;
     MESRKDMVMF LDGGQLGTLV GKRVSNLSEA VSSPLPEPPE KMVPHGCLSP RAGPPTSRER
     GGGGQEEEPV DGLAGSAAGL GAEPRSAGAA MLGPGPPVPS ADSLSGQGQP SSSDTESDFY
     EEIEVSCTPD CATGNAEYQH SKAPGSDALG SSPTSGSEAP KSNGGSGGSG SQGTLACSAS
     DQMRRYRTAF TREQIARLEK EFYRENYVSR PRRCELAAAL NLPETTIKVW FQNRRMKDKR
     QRLAMTWPHP ADPAFYTYMM SHAAAAGGLP YPFPSHLPLP YYSPVGLGAA SAASAAASPF
     SGPLRPLDTF RVLSQPYPRP ELLCAFRHPP LYPGPAHGLG ASAAAAAAAG PCSCLACHSG
     PANGLAPRAA AAAAASDFTC ASTSRSDSFL TFAPSVLSKA SSVAALDQRE EVPLTR
//
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