ID EVX1_MOUSE Reviewed; 416 AA.
AC P23683;
DT 01-NOV-1991, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1991, sequence version 1.
DT 03-APR-2013, entry version 102.
DE RecName: Full=Homeobox even-skipped homolog protein 1;
DE AltName: Full=EVX-1;
GN Name=Evx1;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;
OC Muroidea; Muridae; Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=BALB/c; TISSUE=Liver;
RX PubMed=1971786;
RA Bastian H., Gruss P.;
RT "A murine even-skipped homologue, Evx 1, is expressed during early
RT embryogenesis and neurogenesis in a biphasic manner.";
RL EMBO J. 9:1839-1852(1990).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=BALB/c;
RX PubMed=1349539; DOI=10.1016/0012-1606(92)90232-6;
RA Dush M.K., Martin G.R.;
RT "Analysis of mouse Evx genes: Evx-1 displays graded expression in the
RT primitive streak.";
RL Dev. Biol. 151:273-287(1992).
CC -!- FUNCTION: May play a role in the specification of neuronal cell
CC types. May play a role in the dorsoventral specification of
CC mesodermal cell fate.
CC -!- SUBCELLULAR LOCATION: Nucleus.
CC -!- DEVELOPMENTAL STAGE: Shows a graded distribution in the primitive
CC streak and in cells lateral to it. It is not detected in cells
CC along the A-P axis of the embryo anterior to the primitive streak,
CC except at E7.5 when there is transient expression in the head
CC process. The highest levels of expression are found within the
CC proximal (posterior) portion of the primitive streak and cells
CC near it, with expression levels decreasing more distally
CC (anteriorly).
CC -!- SIMILARITY: Belongs to the even-skipped homeobox family.
CC -!- SIMILARITY: Contains 1 homeobox DNA-binding domain.
CC -----------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution-NoDerivs License
CC -----------------------------------------------------------------------
DR EMBL; X54239; CAA38145.1; -; mRNA.
DR IPI; IPI00134754; -.
DR RefSeq; NP_031992.1; NM_007966.4.
DR UniGene; Mm.389754; -.
DR ProteinModelPortal; P23683; -.
DR SMR; P23683; 185-241.
DR PRIDE; P23683; -.
DR Ensembl; ENSMUST00000031787; ENSMUSP00000031787; ENSMUSG00000005503.
DR GeneID; 14028; -.
DR KEGG; mmu:14028; -.
DR UCSC; uc009byv.1; mouse.
DR CTD; 2128; -.
DR MGI; MGI:95461; Evx1.
DR eggNOG; NOG298527; -.
DR GeneTree; ENSGT00690000102189; -.
DR HOGENOM; HOG000231897; -.
DR HOVERGEN; HBG005620; -.
DR InParanoid; P23683; -.
DR KO; K09320; -.
DR OMA; LACHSGP; -.
DR NextBio; 284956; -.
DR ArrayExpress; P23683; -.
DR Bgee; P23683; -.
DR CleanEx; MM_EVX1; -.
DR Genevestigator; P23683; -.
DR GermOnline; ENSMUSG00000005503; Mus musculus.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR GO; GO:0003700; F:sequence-specific DNA binding transcription factor activity; IEA:InterPro.
DR GO; GO:0009792; P:embryo development ending in birth or egg hatching; IMP:MGI.
DR GO; GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IDA:MGI.
DR GO; GO:0021913; P:regulation of transcription from RNA polymerase II promoter involved in ventral spinal cord interneuron specification; IMP:MGI.
DR Gene3D; 1.10.10.60; -; 1.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR020479; Homeobox_metazoa.
DR InterPro; IPR001356; Homeodomain.
DR InterPro; IPR009057; Homeodomain-like.
DR Pfam; PF00046; Homeobox; 1.
DR PRINTS; PR00024; HOMEOBOX.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; Homeodomain_like; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 2: Evidence at transcript level;
KW Complete proteome; Developmental protein; DNA-binding; Homeobox;
KW Nucleus; Reference proteome.
FT CHAIN 1 416 Homeobox even-skipped homolog protein 1.
FT /FTId=PRO_0000048871.
FT DNA_BIND 183 242 Homeobox.
FT COMPBIAS 114 124 Asp/Glu-rich (acidic).
FT COMPBIAS 289 297 Ala-rich.
FT COMPBIAS 341 349 Ala-rich.
FT COMPBIAS 369 375 Ala-rich.
SQ SEQUENCE 416 AA; 43198 MW; 9F0EE4F3677CD3EE CRC64;
MESRKDMVMF LDGGQLGTLV GKRVSNLSEA VSSPLPEPPE KMVPHGCLSP RAGPPTSRER
GGGGQEEEPV DGLAGSAAGL GAEPRSAGAA MLGPGPPVPS ADSLSGQGQP SSSDTESDFY
EEIEVSCTPD CATGNAEYQH SKAPGSDALG SSPTSGSEAP KSNGGSGGSG SQGTLACSAS
DQMRRYRTAF TREQIARLEK EFYRENYVSR PRRCELAAAL NLPETTIKVW FQNRRMKDKR
QRLAMTWPHP ADPAFYTYMM SHAAAAGGLP YPFPSHLPLP YYSPVGLGAA SAASAAASPF
SGPLRPLDTF RVLSQPYPRP ELLCAFRHPP LYPGPAHGLG ASAAAAAAAG PCSCLACHSG
PANGLAPRAA AAAAASDFTC ASTSRSDSFL TFAPSVLSKA SSVAALDQRE EVPLTR
//
