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Database: UniProt
Entry: P23842
LinkDB: P23842
Original site: P23842 
ID   YFEA_ECOLI              Reviewed;         729 AA.
AC   P23842; P76529; P76954;
DT   01-NOV-1991, integrated into UniProtKB/Swiss-Prot.
DT   27-APR-2001, sequence version 2.
DT   11-JUN-2014, entry version 117.
DE   RecName: Full=Uncharacterized protein YfeA;
GN   Name=yfeA; OrderedLocusNames=b2395, JW5391;
OS   Escherichia coli (strain K12).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacteriales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=83333;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX   PubMed=9205837; DOI=10.1093/dnares/4.2.91;
RA   Yamamoto Y., Aiba H., Baba T., Hayashi K., Inada T., Isono K.,
RA   Itoh T., Kimura S., Kitagawa M., Makino K., Miki T., Mitsuhashi N.,
RA   Mizobuchi K., Mori H., Nakade S., Nakamura Y., Nashimoto H.,
RA   Oshima T., Oyama S., Saito N., Sampei G., Satoh Y., Sivasundaram S.,
RA   Tagami H., Takahashi H., Takeda J., Takemoto K., Uehara K., Wada C.,
RA   Yamagata S., Horiuchi T.;
RT   "Construction of a contiguous 874-kb sequence of the Escherichia coli-
RT   K12 genome corresponding to 50.0-68.8 min on the linkage map and
RT   analysis of its sequence features.";
RL   DNA Res. 4:91-113(1997).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K12 / MG1655 / ATCC 47076;
RX   PubMed=9278503; DOI=10.1126/science.277.5331.1453;
RA   Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V.,
RA   Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F.,
RA   Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J.,
RA   Mau B., Shao Y.;
RT   "The complete genome sequence of Escherichia coli K-12.";
RL   Science 277:1453-1462(1997).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX   PubMed=16738553; DOI=10.1038/msb4100049;
RA   Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S.,
RA   Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.;
RT   "Highly accurate genome sequences of Escherichia coli K-12 strains
RT   MG1655 and W3110.";
RL   Mol. Syst. Biol. 2:E1-E5(2006).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-153.
RC   STRAIN=K12;
RX   PubMed=2201776; DOI=10.1016/0022-2836(90)90339-N;
RA   Brun Y.V., Breton R., Lanouette P., Lapointe J.;
RT   "Precise mapping and comparison of two evolutionarily related regions
RT   of the Escherichia coli K-12 chromosome. Evolution of valU and lysT
RT   from an ancestral tRNA operon.";
RL   J. Mol. Biol. 214:825-843(1990).
RN   [5]
RP   INDUCTION, AND RPOS-REPRESSION.
RC   STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX   PubMed=19332833; DOI=10.1099/mic.0.024257-0;
RA   Sommerfeldt N., Possling A., Becker G., Pesavento C., Tschowri N.,
RA   Hengge R.;
RT   "Gene expression patterns and differential input into curli fimbriae
RT   regulation of all GGDEF/EAL domain proteins in Escherichia coli.";
RL   Microbiology 155:1318-1331(2009).
CC   -!- INDUCTION: Expressed during exponential and post-exponential
CC       growth at both 28 and 37 degrees Celsius. Repressed by RpoS.
CC   -!- SIMILARITY: Contains 1 EAL domain.
CC   -!- SIMILARITY: Contains 1 GGDEF domain.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAA65719.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
CC       Sequence=AAA65719.1; Type=Frameshift; Positions=112;
CC       Sequence=CAA45395.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
CC       Sequence=CAA45395.1; Type=Frameshift; Positions=112;
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DR   EMBL; U00096; AAC75454.2; -; Genomic_DNA.
DR   EMBL; AP009048; BAA16267.2; -; Genomic_DNA.
DR   EMBL; M13687; AAA65719.1; ALT_SEQ; Genomic_DNA.
DR   EMBL; X63976; CAA45395.1; ALT_SEQ; Genomic_DNA.
DR   PIR; H65013; H65013.
DR   PIR; S11411; S11411.
DR   RefSeq; NP_416896.4; NC_000913.3.
DR   RefSeq; YP_490636.1; NC_007779.1.
DR   ProteinModelPortal; P23842; -.
DR   DIP; DIP-12011N; -.
DR   IntAct; P23842; 1.
DR   MINT; MINT-1223642; -.
DR   STRING; 511145.b2395; -.
DR   EnsemblBacteria; AAC75454; AAC75454; b2395.
DR   EnsemblBacteria; BAA16267; BAA16267; BAA16267.
DR   GeneID; 12930192; -.
DR   GeneID; 946864; -.
DR   KEGG; ecj:Y75_p2361; -.
DR   KEGG; eco:b2395; -.
DR   PATRIC; 32120167; VBIEscCol129921_2492.
DR   EchoBASE; EB1135; -.
DR   EcoGene; EG11145; yfeA.
DR   eggNOG; COG2199; -.
DR   HOGENOM; HOG000122953; -.
DR   OMA; SVRFDMQ; -.
DR   OrthoDB; EOG69GZGV; -.
DR   PhylomeDB; P23842; -.
DR   BioCyc; EcoCyc:EG11145-MONOMER; -.
DR   BioCyc; ECOL316407:JW5391-MONOMER; -.
DR   PRO; PR:P23842; -.
DR   Genevestigator; P23842; -.
DR   GO; GO:0016849; F:phosphorus-oxygen lyase activity; IEA:InterPro.
DR   GO; GO:0009190; P:cyclic nucleotide biosynthetic process; IEA:InterPro.
DR   GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR   Gene3D; 3.20.20.450; -; 1.
DR   InterPro; IPR001054; A/G_cyclase.
DR   InterPro; IPR001633; Diguanylate_PEstase_EAL_dom.
DR   InterPro; IPR000160; GGDEF_dom.
DR   InterPro; IPR007895; MASE1.
DR   Pfam; PF00563; EAL; 1.
DR   Pfam; PF05231; MASE1; 1.
DR   SMART; SM00052; EAL; 1.
DR   SMART; SM00267; GGDEF; 1.
DR   SUPFAM; SSF141868; SSF141868; 1.
DR   SUPFAM; SSF55073; SSF55073; 1.
DR   PROSITE; PS50883; EAL; 1.
DR   PROSITE; PS50887; GGDEF; 1.
PE   2: Evidence at transcript level;
KW   Complete proteome; Reference proteome.
FT   CHAIN         1    729       Uncharacterized protein YfeA.
FT                                /FTId=PRO_0000169216.
FT   DOMAIN      348    476       GGDEF.
FT   DOMAIN      488    729       EAL.
SQ   SEQUENCE   729 AA;  83524 MW;  F1CF1AA15D592650 CRC64;
     MFVEHNLIKN IKIFTLAFTL TVVLIQLSRF ISPLAIIHSS YIFLAWMPLC VMLSILFIFG
     WRGVVPVLCG MFCTNLWNFH LSFLQTAVML GSQTFVVLCA CAILRWQLGT RWRYGLTSRY
     VWQRLFWLGL VTPIGIKCSM YLVGSFFDFP LKISTFFGDA DAIFTVVDLL SLFTAVLIYN
     MLFYYLTRMI VSPHFAQILW RRDIAPSLGK EKRAFTLSWL AALSVLLLLL CTPYENDFIA
     GYLVPVFFII FTLGVGKLRY PFLNLTWAVS TLCLLNYNQN FLQGVETEYS LAFILAVLIS
     FSVCLLYMVR IYHRSEWLNR RWHLQALTDP LTLLPNFRAL EQAPEQEAGK SFCCLRIDNL
     EFMSRHYGLM MRVHCIRSIC RTLLPLMQEN EKLYQLPGSE LLLVLSGPET EGRLQHMVNI
     LNSRQIHWNN TGLDMGYGAA WGRFDGNQET LQPLLGQLSW LAEQSCAHHH VLALDSREEM
     VSGQTTKQVL LLNTIRTALD QGDLLLYAQP IRNKEGEGYD EILARLKYDG GIMTPDKFLP
     LIAQFNLSAR FDLQVLESLL KWLATHPCDK KGPRFSVNLM PLTLLQKNIA GRIIRLFKRY
     HISPQAVILE ITEEQAFSNA ESSMYNIEQL HKFGFRIAID DFGTGYANYE RLKRLQADII
     KIDGVFVKDI VTNTLDAMIV RSITDLAKAK SLSVVAEFVE TQQQQALLHK LGVQYLQGYL
     IGRPQPLAD
//
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