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Database: UniProt
Entry: P23902
LinkDB: P23902
Original site: P23902 
ID   KASC1_HORVU             Reviewed;         462 AA.
AC   P23902;
DT   01-NOV-1991, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1991, sequence version 1.
DT   16-OCT-2013, entry version 78.
DE   RecName: Full=3-oxoacyl-[acyl-carrier-protein] synthase I, chloroplastic;
DE            EC=2.3.1.41;
DE   AltName: Full=Beta-ketoacyl-ACP synthase I;
DE            Short=KAS I;
DE   Flags: Precursor;
GN   Name=KAS12;
OS   Hordeum vulgare (Barley).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliophyta; Liliopsida; Poales; Poaceae; BEP clade;
OC   Pooideae; Triticeae; Hordeum.
OX   NCBI_TaxID=4513;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND PARTIAL PROTEIN SEQUENCE.
RC   STRAIN=cv. Bonus;
RX   PubMed=2034657; DOI=10.1073/pnas.88.10.4114;
RA   Siggaard-Andersen M., Kauppinen S., von Wettstein-Knowles P.;
RT   "Primary structure of a cerulenin-binding beta-ketoacyl-[acyl carrier
RT   protein] synthase from barley chloroplasts.";
RL   Proc. Natl. Acad. Sci. U.S.A. 88:4114-4118(1991).
CC   -!- FUNCTION: Catalyzes the condensation reaction of fatty acid
CC       synthesis by the addition to an acyl acceptor of two carbons from
CC       malonyl-ACP. Specific for elongation from C-10 to unsaturated C-16
CC       and C-18 fatty acids.
CC   -!- CATALYTIC ACTIVITY: Acyl-[acyl-carrier-protein] + malonyl-[acyl-
CC       carrier-protein] = 3-oxoacyl-[acyl-carrier-protein] + CO(2) +
CC       [acyl-carrier-protein].
CC   -!- SUBUNIT: Homodimer.
CC   -!- SUBCELLULAR LOCATION: Plastid, chloroplast.
CC   -!- SIMILARITY: Belongs to the beta-ketoacyl-ACP synthases family.
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DR   EMBL; M60410; AAA32968.1; -; mRNA.
DR   PIR; A39356; A39356.
DR   UniGene; Hv.115; -.
DR   ProteinModelPortal; P23902; -.
DR   PRIDE; P23902; -.
DR   Gramene; P23902; -.
DR   Genevestigator; P23902; -.
DR   GO; GO:0009507; C:chloroplast; IEA:UniProtKB-SubCell.
DR   GO; GO:0004315; F:3-oxoacyl-[acyl-carrier-protein] synthase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006633; P:fatty acid biosynthetic process; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.47.10; -; 2.
DR   InterPro; IPR017568; 3-oxoacyl-ACP_synth-2.
DR   InterPro; IPR018201; Ketoacyl_synth_AS.
DR   InterPro; IPR014031; Ketoacyl_synth_C.
DR   InterPro; IPR014030; Ketoacyl_synth_N.
DR   InterPro; IPR016039; Thiolase-like.
DR   InterPro; IPR016038; Thiolase-like_subgr.
DR   Pfam; PF00109; ketoacyl-synt; 1.
DR   Pfam; PF02801; Ketoacyl-synt_C; 1.
DR   PIRSF; PIRSF000447; KAS_II; 1.
DR   SUPFAM; SSF53901; SSF53901; 2.
DR   TIGRFAMs; TIGR03150; fabF; 1.
DR   PROSITE; PS00606; B_KETOACYL_SYNTHASE; 1.
PE   1: Evidence at protein level;
KW   Acyltransferase; Chloroplast; Direct protein sequencing;
KW   Fatty acid biosynthesis; Fatty acid metabolism; Lipid biosynthesis;
KW   Lipid metabolism; Plastid; Transferase; Transit peptide.
FT   TRANSIT       1     35       Chloroplast.
FT   CHAIN        36    462       3-oxoacyl-[acyl-carrier-protein] synthase
FT                                I, chloroplastic.
FT                                /FTId=PRO_0000000587.
FT   ACT_SITE    213    213       By similarity.
SQ   SEQUENCE   462 AA;  49016 MW;  BDFA3622263A7764 CRC64;
     MHAHAAHALG LRVPPPAFPR RRARPRRRPA AAVLATSAAP QRETDPRKRV VITGMGLASV
     FGSDVDTFYD RLLAGESGVG PIDRFDASSF PTRFAGQIRG FSSEGYIDGK NDRRLDDCIR
     YCILSGKKAL ESAGLGAGSD AHVKLDVGRA GVLVGTGMGG LSVFSDGVQN LIEKGYRKIS
     PFFIPYAITN MGSALLAIDV GFMGPNYSIS TACATSNYCF YAAANHIRRG EADIIVAGGT
     EAAIIPIGLG GFVACRALSQ RNDDPITACR PWDKERDGFV MGEGAGVLVM ESLEHAMKRD
     APIIAEYLGG AVNCDAYHMT DPRADGLGVS SCITMSLRDA GVAPEEVNYI NAHATSTLAG
     DLAEVRAIKQ VFKNPSEIKI NSTKSMIGHC LGAAGGLEAI ATIKSITTGW VHPTINQFNP
     EPEVDFDTVA NEKKQHEVNV GISNSFGFGG HNSVVVFAPF KP
//
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