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Database: UniProt
Entry: P25377
LinkDB: P25377
Original site: P25377 
ID   ADH7_YEAST              Reviewed;         361 AA.
AC   P25377; D6VRA5;
DT   01-MAY-1992, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1992, sequence version 1.
DT   14-MAY-2014, entry version 113.
DE   RecName: Full=NADP-dependent alcohol dehydrogenase 7;
DE            EC=1.1.1.2;
DE   AltName: Full=NADP-dependent alcohol dehydrogenase VII;
DE            Short=ADHVII;
GN   Name=ADH7; OrderedLocusNames=YCR105W;
OS   Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina;
OC   Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX   NCBI_TaxID=559292;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 204508 / S288c;
RX   PubMed=1574125; DOI=10.1038/357038a0;
RA   Oliver S.G., van der Aart Q.J.M., Agostoni-Carbone M.L., Aigle M.,
RA   Alberghina L., Alexandraki D., Antoine G., Anwar R., Ballesta J.P.G.,
RA   Benit P., Berben G., Bergantino E., Biteau N., Bolle P.-A.,
RA   Bolotin-Fukuhara M., Brown A., Brown A.J.P., Buhler J.-M., Carcano C.,
RA   Carignani G., Cederberg H., Chanet R., Contreras R., Crouzet M.,
RA   Daignan-Fornier B., Defoor E., Delgado M.D., Demolder J., Doira C.,
RA   Dubois E., Dujon B., Duesterhoeft A., Erdmann D., Esteban M.,
RA   Fabre F., Fairhead C., Faye G., Feldmann H., Fiers W.,
RA   Francingues-Gaillard M.-C., Franco L., Frontali L., Fukuhara H.,
RA   Fuller L.J., Galland P., Gent M.E., Gigot D., Gilliquet V.,
RA   Glansdorff N., Goffeau A., Grenson M., Grisanti P., Grivell L.A.,
RA   de Haan M., Haasemann M., Hatat D., Hoenicka J., Hegemann J.H.,
RA   Herbert C.J., Hilger F., Hohmann S., Hollenberg C.P., Huse K.,
RA   Iborra F., Indge K.J., Isono K., Jacq C., Jacquet M., James C.M.,
RA   Jauniaux J.-C., Jia Y., Jimenez A., Kelly A., Kleinhans U., Kreisl P.,
RA   Lanfranchi G., Lewis C., van der Linden C.G., Lucchini G.,
RA   Lutzenkirchen K., Maat M.J., Mallet L., Mannhaupt G., Martegani E.,
RA   Mathieu A., Maurer C.T.C., McConnell D., McKee R.A., Messenguy F.,
RA   Mewes H.-W., Molemans F., Montague M.A., Muzi Falconi M., Navas L.,
RA   Newlon C.S., Noone D., Pallier C., Panzeri L., Pearson B.M., Perea J.,
RA   Philippsen P., Pierard A., Planta R.J., Plevani P., Poetsch B.,
RA   Pohl F.M., Purnelle B., Ramezani Rad M., Rasmussen S.W., Raynal A.,
RA   Remacha M.A., Richterich P., Roberts A.B., Rodriguez F., Sanz E.,
RA   Schaaff-Gerstenschlaeger I., Scherens B., Schweitzer B., Shu Y.,
RA   Skala J., Slonimski P.P., Sor F., Soustelle C., Spiegelberg R.,
RA   Stateva L.I., Steensma H.Y., Steiner S., Thierry A., Thireos G.,
RA   Tzermia M., Urrestarazu L.A., Valle G., Vetter I.,
RA   van Vliet-Reedijk J.C., Voet M., Volckaert G., Vreken P., Wang H.,
RA   Warmington J.R., von Wettstein D., Wicksteed B.L., Wilson C.,
RA   Wurst H., Xu G., Yoshikawa A., Zimmermann F.K., Sgouros J.G.;
RT   "The complete DNA sequence of yeast chromosome III.";
RL   Nature 357:38-46(1992).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=ATCC 204508 / S288c;
RX   PubMed=24374639; DOI=10.1534/g3.113.008995;
RA   Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA   Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA   Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M.,
RA   Cherry J.M.;
RT   "The reference genome sequence of Saccharomyces cerevisiae: Then and
RT   now.";
RL   G3 (Bethesda) 4:389-398(2014).
RN   [3]
RP   CHARACTERIZATION, AND SUBUNIT.
RX   PubMed=12423374; DOI=10.1046/j.1432-1033.2002.03296.x;
RA   Larroy C., Pares X., Biosca J.A.;
RT   "Characterization of a Saccharomyces cerevisiae NADP(H)-dependent
RT   alcohol dehydrogenase (ADHVII), a member of the cinnamyl alcohol
RT   dehydrogenase family.";
RL   Eur. J. Biochem. 269:5738-5745(2002).
RN   [4]
RP   LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
RX   PubMed=14562106; DOI=10.1038/nature02046;
RA   Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A.,
RA   Dephoure N., O'Shea E.K., Weissman J.S.;
RT   "Global analysis of protein expression in yeast.";
RL   Nature 425:737-741(2003).
RN   [5]
RP   PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-316, AND IDENTIFICATION
RP   BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=17287358; DOI=10.1073/pnas.0607084104;
RA   Chi A., Huttenhower C., Geer L.Y., Coon J.J., Syka J.E.P., Bai D.L.,
RA   Shabanowitz J., Burke D.J., Troyanskaya O.G., Hunt D.F.;
RT   "Analysis of phosphorylation sites on proteins from Saccharomyces
RT   cerevisiae by electron transfer dissociation (ETD) mass
RT   spectrometry.";
RL   Proc. Natl. Acad. Sci. U.S.A. 104:2193-2198(2007).
CC   -!- FUNCTION: NADP-dependent alcohol dehydrogenase with a broad
CC       substrate specificity.
CC   -!- CATALYTIC ACTIVITY: An alcohol + NADP(+) = an aldehyde + NADPH.
CC   -!- COFACTOR: Binds 2 zinc ions per subunit (By similarity).
CC   -!- SUBUNIT: Homodimer.
CC   -!- MISCELLANEOUS: Present with 2870 molecules/cell in log phase SD
CC       medium.
CC   -!- SIMILARITY: Belongs to the zinc-containing alcohol dehydrogenase
CC       family.
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DR   EMBL; X59720; CAA42237.1; -; Genomic_DNA.
DR   EMBL; BK006937; DAA07574.1; -; Genomic_DNA.
DR   PIR; S19417; S19417.
DR   RefSeq; NP_010030.1; NM_001178812.1.
DR   ProteinModelPortal; P25377; -.
DR   SMR; P25377; 1-359.
DR   BioGrid; 31077; 14.
DR   DIP; DIP-7661N; -.
DR   MINT; MINT-2789097; -.
DR   STRING; 4932.YCR105W; -.
DR   PaxDb; P25377; -.
DR   EnsemblFungi; YCR105W; YCR105W; YCR105W.
DR   GeneID; 850469; -.
DR   KEGG; sce:YCR105W; -.
DR   CYGD; YCR105w; -.
DR   SGD; S000000702; ADH7.
DR   eggNOG; COG1064; -.
DR   GeneTree; ENSGT00750000118226; -.
DR   HOGENOM; HOG000294667; -.
DR   KO; K00002; -.
DR   OrthoDB; EOG757D7B; -.
DR   BioCyc; YEAST:YCR105W-MONOMER; -.
DR   NextBio; 966116; -.
DR   Genevestigator; P25377; -.
DR   GO; GO:0008106; F:alcohol dehydrogenase (NADP+) activity; IDA:SGD.
DR   GO; GO:0048037; F:cofactor binding; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0006066; P:alcohol metabolic process; IDA:SGD.
DR   Gene3D; 3.40.50.720; -; 1.
DR   Gene3D; 3.90.180.10; -; 1.
DR   InterPro; IPR013149; ADH_C.
DR   InterPro; IPR013154; ADH_GroES-like.
DR   InterPro; IPR002085; ADH_SF_Zn-type.
DR   InterPro; IPR002328; ADH_Zn_CS.
DR   InterPro; IPR006140; D-isomer_2_OHA_DH_NAD-bd.
DR   InterPro; IPR011032; GroES-like.
DR   InterPro; IPR016040; NAD(P)-bd_dom.
DR   PANTHER; PTHR11695; PTHR11695; 1.
DR   Pfam; PF08240; ADH_N; 1.
DR   Pfam; PF00107; ADH_zinc_N; 1.
DR   SUPFAM; SSF50129; SSF50129; 1.
DR   PROSITE; PS00059; ADH_ZINC; 1.
PE   1: Evidence at protein level;
KW   Complete proteome; Metal-binding; NADP; Oxidoreductase;
KW   Phosphoprotein; Reference proteome; Zinc.
FT   CHAIN         1    361       NADP-dependent alcohol dehydrogenase 7.
FT                                /FTId=PRO_0000160735.
FT   NP_BIND     188    193       NAD (By similarity).
FT   NP_BIND     276    278       NAD (By similarity).
FT   METAL        46     46       Zinc 1; catalytic (By similarity).
FT   METAL        68     68       Zinc 1; catalytic (By similarity).
FT   METAL       100    100       Zinc 2 (By similarity).
FT   METAL       103    103       Zinc 2 (By similarity).
FT   METAL       106    106       Zinc 2 (By similarity).
FT   METAL       114    114       Zinc 2 (By similarity).
FT   METAL       164    164       Zinc 1; catalytic (By similarity).
FT   BINDING     216    216       NAD (By similarity).
FT   BINDING     349    349       NAD (By similarity).
FT   MOD_RES     316    316       Phosphoserine.
SQ   SEQUENCE   361 AA;  39348 MW;  BFB0E6C5F93D3F07 CRC64;
     MLYPEKFQGI GISNAKDWKH PKLVSFDPKP FGDHDVDVEI EACGICGSDF HIAVGNWGPV
     PENQILGHEI IGRVVKVGSK CHTGVKIGDR VGVGAQALAC FECERCKSDN EQYCTNDHVL
     TMWTPYKDGY ISQGGFASHV RLHEHFAIQI PENIPSPLAA PLLCGGITVF SPLLRNGCGP
     GKRVGIVGIG GIGHMGILLA KAMGAEVYAF SRGHSKREDS MKLGADHYIA MLEDKGWTEQ
     YSNALDLLVV CSSSLSKVNF DSIVKIMKIG GSIVSIAAPE VNEKLVLKPL GLMGVSISSS
     AIGSRKEIEQ LLKLVSEKNV KIWVEKLPIS EEGVSHAFTR MESGDVKYRF TLVDYDKKFH
     K
//
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