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Database: UniProt
Entry: P26421
LinkDB: P26421
Original site: P26421 
ID   LACC_STRMU              Reviewed;         310 AA.
AC   P26421;
DT   01-AUG-1992, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1992, sequence version 1.
DT   19-FEB-2014, entry version 101.
DE   RecName: Full=Tagatose-6-phosphate kinase;
DE            EC=2.7.1.144;
DE   AltName: Full=Phosphotagatokinase;
GN   Name=lacC; OrderedLocusNames=SMU_1494;
OS   Streptococcus mutans serotype c (strain ATCC 700610 / UA159).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC   Streptococcus.
OX   NCBI_TaxID=210007;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=1400164;
RA   Rosey E.L., Stewart G.C.;
RT   "Nucleotide and deduced amino acid sequences of the lacR, lacABCD, and
RT   lacFE genes encoding the repressor, tagatose 6-phosphate gene cluster,
RT   and sugar-specific phosphotransferase system components of the lactose
RT   operon of Streptococcus mutans.";
RL   J. Bacteriol. 174:6159-6170(1992).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700610 / UA159;
RX   PubMed=12397186; DOI=10.1073/pnas.172501299;
RA   Ajdic D.J., McShan W.M., McLaughlin R.E., Savic G., Chang J.,
RA   Carson M.B., Primeaux C., Tian R., Kenton S., Jia H.G., Lin S.P.,
RA   Qian Y., Li S., Zhu H., Najar F.Z., Lai H., White J., Roe B.A.,
RA   Ferretti J.J.;
RT   "Genome sequence of Streptococcus mutans UA159, a cariogenic dental
RT   pathogen.";
RL   Proc. Natl. Acad. Sci. U.S.A. 99:14434-14439(2002).
CC   -!- CATALYTIC ACTIVITY: ATP + D-tagatose 6-phosphate = ADP + D-
CC       tagatose 1,6-bisphosphate.
CC   -!- PATHWAY: Carbohydrate metabolism; D-tagatose 6-phosphate
CC       degradation; D-glyceraldehyde 3-phosphate and glycerone phosphate
CC       from D-tagatose 6-phosphate: step 1/2.
CC   -!- SIMILARITY: Belongs to the carbohydrate kinase PfkB family. LacC
CC       subfamily.
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DR   EMBL; M80797; AAA26906.1; -; Genomic_DNA.
DR   EMBL; AE014133; AAN59148.1; -; Genomic_DNA.
DR   PIR; E43258; E43258.
DR   RefSeq; NP_721842.1; NC_004350.2.
DR   ProteinModelPortal; P26421; -.
DR   SMR; P26421; 1-310.
DR   STRING; 210007.SMU.1494; -.
DR   EnsemblBacteria; AAN59148; AAN59148; SMU_1494.
DR   GeneID; 1028736; -.
DR   KEGG; smu:SMU_1494; -.
DR   PATRIC; 19665003; VBIStrMut61772_1330.
DR   eggNOG; COG1105; -.
DR   KO; K00917; -.
DR   OMA; NTMEAET; -.
DR   OrthoDB; EOG61KBKF; -.
DR   ProtClustDB; CLSK2462152; -.
DR   BioCyc; SMUT210007:GC7Z-1403-MONOMER; -.
DR   UniPathway; UPA00704; UER00715.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0009024; F:tagatose-6-phosphate kinase activity; ISA:CACAO.
DR   GO; GO:2001059; P:D-tagatose 6-phosphate catabolic process; IEA:UniProtKB-UniPathway.
DR   GO; GO:0019512; P:lactose catabolic process via tagatose-6-phosphate; IEA:InterPro.
DR   HAMAP; MF_01557; LacC; 1.
DR   InterPro; IPR002173; Carboh/pur_kinase_PfkB_CS.
DR   InterPro; IPR005926; LacC.
DR   InterPro; IPR011611; PfkB_dom.
DR   InterPro; IPR017583; Tagatose/fructose_Pkinase.
DR   Pfam; PF00294; PfkB; 1.
DR   PIRSF; PIRSF000535; 1PFK/6PFK/LacC; 1.
DR   TIGRFAMs; TIGR03168; 1-PFK; 1.
DR   TIGRFAMs; TIGR01231; lacC; 1.
DR   PROSITE; PS00583; PFKB_KINASES_1; 1.
DR   PROSITE; PS00584; PFKB_KINASES_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Complete proteome; Kinase; Lactose metabolism;
KW   Nucleotide-binding; Transferase.
FT   CHAIN         1    310       Tagatose-6-phosphate kinase.
FT                                /FTId=PRO_0000203930.
SQ   SEQUENCE   310 AA;  33363 MW;  3A77E913FC7B0D4E CRC64;
     MMLTVTMNPS IDIAYQLDDL KVDTVNRVIE THKTPGGKGL NVTRVLSQLG DDVLASGLLG
     GKLGEFLEAE LDKSAIKHSF YKISAETRNC IAILHGGYQT EILEQGPYVS AKESKGFLEF
     FEKLLPKLEV VAISGSLPKG VPVDYYSQMI AICKQHQVPI VLDCSGQALL EVLNGAAKPT
     VIKPNTEELS QIMEREITND VAVLKHALAS PIFSGIDWII VSLGSQGAFA KHGQTFYKVT
     IPKIAVVNPV GSGDSTVAGI TSALAAGASD EKLLKKANTL GMLNAQEKLT GHVNLENYDN
     LYQQIEVAEV
//
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