ID OPS1_DROPS Reviewed; 373 AA.
AC P28678; Q294T3; Q56RD3; Q8I154; Q8STC6;
DT 01-DEC-1992, integrated into UniProtKB/Swiss-Prot.
DT 16-DEC-2008, sequence version 4.
DT 01-MAY-2013, entry version 92.
DE RecName: Full=Opsin Rh1;
DE AltName: Full=Outer R1-R6 photoreceptor cells opsin;
GN Name=ninaE; Synonyms=Rh1; ORFNames=GA18249;
OS Drosophila pseudoobscura pseudoobscura (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
OC Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha;
OC Ephydroidea; Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=46245;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=Apple Hill;
RX PubMed=1398053;
RA Carulli J.P., Hartl D.L.;
RT "Variable rates of evolution among Drosophila opsin genes.";
RL Genetics 132:193-204(1992).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=Tucson 14011-0121.4;
RX PubMed=12537575;
RA Bergman C.M., Pfeiffer B.D., Rincon-Limas D.E., Hoskins R.A.,
RA Gnirke A., Mungall C.J., Wang A.M., Kronmiller B., Pacleb J.M.,
RA Park S., Stapleton M., Wan K.H., George R.A., de Jong P.J., Botas J.,
RA Rubin G.M., Celniker S.E.;
RT "Assessing the impact of comparative genomic sequence data on the
RT functional annotation of the Drosophila genome.";
RL Genome Biol. 3:RESEARCH0086.1-RESEARCH0086.20(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=15545653; DOI=10.1534/genetics.104.033068;
RA Bartolome C., Maside X., Yi S., Grant A.L., Charlesworth B.;
RT "Patterns of selection on synonymous and nonsynonymous variants in
RT Drosophila miranda.";
RL Genetics 169:1495-1507(2005).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MV2-25 / Tucson 14011-0121.94;
RX PubMed=15632085; DOI=10.1101/gr.3059305;
RA Richards S., Liu Y., Bettencourt B.R., Hradecky P., Letovsky S.,
RA Nielsen R., Thornton K., Hubisz M.J., Chen R., Meisel R.P.,
RA Couronne O., Hua S., Smith M.A., Zhang P., Liu J., Bussemaker H.J.,
RA van Batenburg M.F., Howells S.L., Scherer S.E., Sodergren E.,
RA Matthews B.B., Crosby M.A., Schroeder A.J., Ortiz-Barrientos D.,
RA Rives C.M., Metzker M.L., Muzny D.M., Scott G., Steffen D.,
RA Wheeler D.A., Worley K.C., Havlak P., Durbin K.J., Egan A., Gill R.,
RA Hume J., Morgan M.B., Miner G., Hamilton C., Huang Y., Waldron L.,
RA Verduzco D., Clerc-Blankenburg K.P., Dubchak I., Noor M.A.F.,
RA Anderson W., White K.P., Clark A.G., Schaeffer S.W., Gelbart W.M.,
RA Weinstock G.M., Gibbs R.A.;
RT "Comparative genome sequencing of Drosophila pseudoobscura:
RT chromosomal, gene, and cis-element evolution.";
RL Genome Res. 15:1-18(2005).
RN [5]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 30-341.
RC STRAIN=Abajo36, AF2, AFC12, AFC3, AFC7, Flagstaff14, Flagstaff16,
RC Flagstaff18, Flagstaff5, Mather10, Mather17, Mather32, Mather48,
RC Mather52, MSH10, MSH21, and MSH32;
RX PubMed=11919289;
RA Machado C.A., Kliman R.M., Markert J.A., Hey J.;
RT "Inferring the history of speciation from multilocus DNA sequence
RT data: the case of Drosophila pseudoobscura and close relatives.";
RL Mol. Biol. Evol. 19:472-488(2002).
CC -!- FUNCTION: Visual pigments are the light-absorbing molecules that
CC mediate vision. They consist of an apoprotein, opsin, covalently
CC linked to cis-retinal.
CC -!- BIOPHYSICOCHEMICAL PROPERTIES:
CC Absorption:
CC Abs(max)=480 nm;
CC -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
CC -!- PTM: Phosphorylated on some or all of the serine and threonine
CC residues present in the C-terminal region.
CC -!- MISCELLANEOUS: Each Drosophila eye is composed of 800 facets or
CC ommatidia. Each ommatidium contains 8 photoreceptor cells (R1-R8),
CC the R1 to R6 cells are outer cells, while R7 and R8 are inner
CC cells.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC Opsin subfamily.
CC -----------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution-NoDerivs License
CC -----------------------------------------------------------------------
DR EMBL; X65877; CAA46708.1; -; Genomic_DNA.
DR EMBL; AY190960; AAO01119.1; -; Genomic_DNA.
DR EMBL; AY754574; AAX13149.1; -; Genomic_DNA.
DR EMBL; CM000070; EAL28881.2; -; Genomic_DNA.
DR EMBL; AF450965; AAM09428.1; -; Genomic_DNA.
DR EMBL; AF450966; AAM09429.1; -; Genomic_DNA.
DR EMBL; AF450967; AAM09430.1; -; Genomic_DNA.
DR EMBL; AF450968; AAM09431.1; -; Genomic_DNA.
DR EMBL; AF450969; AAM09432.1; -; Genomic_DNA.
DR EMBL; AF450970; AAM09433.1; -; Genomic_DNA.
DR EMBL; AF450971; AAM09434.1; -; Genomic_DNA.
DR EMBL; AF450972; AAM09435.1; -; Genomic_DNA.
DR EMBL; AF450973; AAM09436.1; -; Genomic_DNA.
DR EMBL; AF450974; AAM09437.1; -; Genomic_DNA.
DR EMBL; AF450975; AAM09438.1; -; Genomic_DNA.
DR EMBL; AF450976; AAM09439.1; -; Genomic_DNA.
DR EMBL; AF450977; AAM09440.1; -; Genomic_DNA.
DR EMBL; AF450978; AAM09441.1; -; Genomic_DNA.
DR EMBL; AF450979; AAM09442.1; -; Genomic_DNA.
DR EMBL; AF450980; AAM09443.1; -; Genomic_DNA.
DR EMBL; AF450981; AAM09444.1; -; Genomic_DNA.
DR PIR; S40691; S40691.
DR RefSeq; XP_001359729.2; XM_001359692.2.
DR ProteinModelPortal; P28678; -.
DR DIP; DIP-769N; -.
DR STRING; 7237.FBpp0284713; -.
DR EnsemblMetazoa; FBtr0286275; FBpp0284713; FBgn0012733.
DR GeneID; 4802902; -.
DR KEGG; dpo:Dpse_GA18249; -.
DR FlyBase; FBgn0012733; Dpse\ninaE.
DR eggNOG; NOG255465; -.
DR InParanoid; P28678; -.
DR KO; K13802; -.
DR OrthoDB; EOG451C6G; -.
DR GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
DR GO; GO:0004930; F:G-protein coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0009881; F:photoreceptor activity; IEA:UniProtKB-KW.
DR GO; GO:0007602; P:phototransduction; IEA:UniProtKB-KW.
DR GO; GO:0018298; P:protein-chromophore linkage; IEA:UniProtKB-KW.
DR GO; GO:0007601; P:visual perception; IEA:UniProtKB-KW.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR001760; Opsin.
DR InterPro; IPR001735; Opsin_RH1/RH2.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00238; OPSIN.
DR PRINTS; PR00576; OPSINRH1RH2.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
DR PROSITE; PS00238; OPSIN; 1.
PE 1: Evidence at protein level;
KW Chromophore; Complete proteome; Disulfide bond;
KW G-protein coupled receptor; Glycoprotein; Membrane; Phosphoprotein;
KW Photoreceptor protein; Receptor; Reference proteome; Retinal protein;
KW Sensory transduction; Transducer; Transmembrane; Transmembrane helix;
KW Vision.
FT CHAIN 1 373 Opsin Rh1.
FT /FTId=PRO_0000197623.
FT TOPO_DOM 1 54 Extracellular (Potential).
FT TRANSMEM 55 75 Helical; Name=1; (Potential).
FT TOPO_DOM 76 86 Cytoplasmic (Potential).
FT TRANSMEM 87 107 Helical; Name=2; (Potential).
FT TOPO_DOM 108 124 Extracellular (Potential).
FT TRANSMEM 125 145 Helical; Name=3; (Potential).
FT TOPO_DOM 146 162 Cytoplasmic (Potential).
FT TRANSMEM 163 183 Helical; Name=4; (Potential).
FT TOPO_DOM 184 219 Extracellular (Potential).
FT TRANSMEM 220 240 Helical; Name=5; (Potential).
FT TOPO_DOM 241 276 Cytoplasmic (Potential).
FT TRANSMEM 277 297 Helical; Name=6; (Potential).
FT TOPO_DOM 298 308 Extracellular (Potential).
FT TRANSMEM 309 331 Helical; Name=7; (Potential).
FT TOPO_DOM 332 373 Cytoplasmic (Potential).
FT MOD_RES 319 319 N6-(retinylidene)lysine.
FT CARBOHYD 20 20 N-linked (GlcNAc...) (Potential).
FT CARBOHYD 196 196 N-linked (GlcNAc...) (Potential).
FT DISULFID 123 200 Potential.
FT CONFLICT 1 2 MD -> CC (in Ref. 3; AAX13149).
FT CONFLICT 14 14 H -> Q (in Ref. 1; CAA46708).
FT CONFLICT 18 18 L -> P (in Ref. 1; CAA46708).
FT CONFLICT 40 40 N -> D (in Ref. 1; CAA46708).
FT CONFLICT 178 178 S -> T (in Ref. 1; CAA46708).
FT CONFLICT 181 181 C -> CC (in Ref. 1; CAA46708).
FT CONFLICT 366 366 N -> T (in Ref. 1; CAA46708).
SQ SEQUENCE 373 AA; 41524 MW; 80E580372EC4EABB CRC64;
MDSFAAVATQ LGPHFAALSN GSVVDKVTPD MAHLISPYWN QFPAMDPIWA KILTAYMIII
GMISWCGNGV VIYIFATTKS LRTPANLLVI NLAISDFGIM ITNTPMMGIN LYFETWVLGP
MMCDIYAGLG SAFGCSSIWS MCMISLDRYQ VIVKGMAGRP MTIPLALGKI AYIWFMSSIW
CLAPVFGWSR YVPEGNLTSC GIDYLERDWN PRSYLIFYSI FVYYIPLFLI CYSYWFIIAA
VSAHEKAMRE QAKKMNVKSL RSSEDADKSA EGKLAKVALV TISLWFMAWT PYLVINCMGL
FKFEGLTPLN TIWGACFAKS AACYNPIVYG ISHPKYRLAL KEKCPCCVFG KVDDGKSSEA
QSQATNSEAE SKA
//
