Database: UniProt
Entry: P29653
LinkDB: P29653
Original site: P29653 
ID   COX1_SALTR              Reviewed;         109 AA.
AC   P29653;
DT   01-APR-1993, integrated into UniProtKB/Swiss-Prot.
DT   01-APR-1993, sequence version 1.
DT   25-OCT-2017, entry version 89.
DE   RecName: Full=Cytochrome c oxidase subunit 1;
DE            EC=;
DE   AltName: Full=Cytochrome c oxidase polypeptide I;
DE   Flags: Fragment;
GN   Name=mt-co1; Synonyms=coi, coxi, mtco1;
OS   Salmo trutta (Brown trout).
OG   Mitochondrion.
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii;
OC   Salmoniformes; Salmonidae; Salmoninae; Salmo.
OX   NCBI_TaxID=8032;
RN   [1]
RX   PubMed=1663569;
RA   Normark B.B., McCune A.R., Harrison R.G.;
RT   "Phylogenetic relationships of neopterygian fishes, inferred from
RT   mitochondrial DNA sequences.";
RL   Mol. Biol. Evol. 8:819-834(1991).
CC   -!- FUNCTION: Cytochrome c oxidase is the component of the respiratory
CC       chain that catalyzes the reduction of oxygen to water. Subunits 1-
CC       3 form the functional core of the enzyme complex. CO I is the
CC       catalytic subunit of the enzyme. Electrons originating in
CC       cytochrome c are transferred via the copper A center of subunit 2
CC       and heme A of subunit 1 to the bimetallic center formed by heme A3
CC       and copper B.
CC   -!- CATALYTIC ACTIVITY: 4 ferrocytochrome c + O(2) + 4 H(+) = 4
CC       ferricytochrome c + 2 H(2)O.
CC   -!- PATHWAY: Energy metabolism; oxidative phosphorylation.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane; Multi-pass
CC       membrane protein.
CC   -!- SIMILARITY: Belongs to the heme-copper respiratory oxidase family.
CC       {ECO:0000305}.
DR   EMBL; M64917; AAB01484.1; -; Genomic_DNA.
DR   ProteinModelPortal; P29653; -.
DR   UniPathway; UPA00705; -.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0045277; C:respiratory chain complex IV; ISS:UniProtKB.
DR   GO; GO:0004129; F:cytochrome-c oxidase activity; IEA:UniProtKB-EC.
DR   GO; GO:0020037; F:heme binding; IEA:InterPro.
DR   GO; GO:0005506; F:iron ion binding; IEA:InterPro.
DR   GO; GO:0009060; P:aerobic respiration; IEA:InterPro.
DR   GO; GO:0006119; P:oxidative phosphorylation; IEA:UniProtKB-UniPathway.
DR   Gene3D;; -; 1.
DR   InterPro; IPR023616; Cyt_c_oxase-like_su1_dom.
DR   InterPro; IPR036927; Cyt_c_oxase-like_su1_sf.
DR   InterPro; IPR000883; Cyt_C_Oxase_1.
DR   InterPro; IPR023615; Cyt_c_Oxase_su1_BS.
DR   PANTHER; PTHR10422; PTHR10422; 1.
DR   Pfam; PF00115; COX1; 1.
DR   SUPFAM; SSF81442; SSF81442; 1.
DR   PROSITE; PS50855; COX1; 1.
DR   PROSITE; PS00077; COX1_CUB; 1.
PE   3: Inferred from homology;
KW   Copper; Electron transport; Heme; Iron; Membrane; Metal-binding;
KW   Mitochondrion; Mitochondrion inner membrane; Oxidoreductase;
KW   Respiratory chain; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN        <1   >109       Cytochrome c oxidase subunit 1.
FT                                /FTId=PRO_0000183412.
FT   TRANSMEM      1     21       Helical. {ECO:0000255}.
FT   TRANSMEM     34     54       Helical. {ECO:0000255}.
FT   TRANSMEM     76     96       Helical. {ECO:0000255}.
FT   METAL         6      6       Copper B. {ECO:0000305}.
FT   METAL        10     10       Copper B. {ECO:0000305}.
FT   METAL        56     56       Copper B. {ECO:0000305}.
FT   METAL        57     57       Copper B. {ECO:0000305}.
FT   CROSSLNK      6     10       1'-histidyl-3'-tyrosine (His-Tyr).
FT                                {ECO:0000250}.
FT   NON_TER       1      1
FT   NON_TER     109    109
SQ   SEQUENCE   109 AA;  12251 MW;  0A513F2CE5B85C25 CRC64;
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