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Database: UniProt
Entry: P31257
LinkDB: P31257
Original site: P31257 
ID   HXC10_MOUSE             Reviewed;         342 AA.
AC   P31257; P31312; Q7TMT7;
DT   01-JUL-1993, integrated into UniProtKB/Swiss-Prot.
DT   01-JUL-1993, sequence version 1.
DT   07-JUN-2017, entry version 140.
DE   RecName: Full=Homeobox protein Hox-C10;
DE   AltName: Full=Homeobox protein Hox-3.6;
GN   Name=Hoxc10; Synonyms=Hox-3.6, Hoxc-10;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
OC   Muroidea; Muridae; Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=CD-1;
RX   PubMed=1353983; DOI=10.1016/0925-4773(92)90077-W;
RA   Peterson R.L., Jacobs D.F., Awgulewitsch A.;
RT   "Hox-3.6: isolation and characterization of a new murine homeobox gene
RT   located in the 5' region of the Hox-3 cluster.";
RL   Mech. Dev. 37:151-166(1992).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=C3H/He; TISSUE=Mesenchymal stem cell;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [3]
RP   NUCLEOTIDE SEQUENCE OF 268-327.
RX   PubMed=1683707; DOI=10.1073/pnas.88.23.10706;
RA   Singh G., Kaur S., Stock J.L., Jenkins N.A., Gilbert D.J.,
RA   Copeland N.G., Potter S.S.;
RT   "Identification of 10 murine homeobox genes.";
RL   Proc. Natl. Acad. Sci. U.S.A. 88:10706-10710(1991).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 289-313.
RX   PubMed=1720547; DOI=10.1073/pnas.88.23.10711;
RA   Murtha M.T., Leckman J.F., Ruddle F.H.;
RT   "Detection of homeobox genes in development and evolution.";
RL   Proc. Natl. Acad. Sci. U.S.A. 88:10711-10715(1991).
CC   -!- FUNCTION: Sequence-specific transcription factor which is part of
CC       a developmental regulatory system that provides cells with
CC       specific positional identities on the anterior-posterior axis.
CC   -!- SUBCELLULAR LOCATION: Nucleus.
CC   -!- SIMILARITY: Belongs to the Abd-B homeobox family. {ECO:0000305}.
DR   EMBL; X63507; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC053405; AAH53405.1; -; mRNA.
DR   EMBL; M81658; AAA63310.1; -; Genomic_DNA.
DR   CCDS; CCDS57014.1; -.
DR   PIR; A56552; A56552.
DR   RefSeq; NP_034592.2; NM_010462.5.
DR   UniGene; Mm.31665; -.
DR   ProteinModelPortal; P31257; -.
DR   SMR; P31257; -.
DR   STRING; 10090.ENSMUSP00000001699; -.
DR   PhosphoSitePlus; P31257; -.
DR   MaxQB; P31257; -.
DR   PaxDb; P31257; -.
DR   PRIDE; P31257; -.
DR   Ensembl; ENSMUST00000001699; ENSMUSP00000001699; ENSMUSG00000022484.
DR   GeneID; 209448; -.
DR   KEGG; mmu:209448; -.
DR   UCSC; uc007xwz.2; mouse.
DR   CTD; 3226; -.
DR   MGI; MGI:96192; Hoxc10.
DR   eggNOG; KOG0487; Eukaryota.
DR   eggNOG; ENOG4111FJP; LUCA.
DR   GeneTree; ENSGT00760000118834; -.
DR   HOGENOM; HOG000231182; -.
DR   HOVERGEN; HBG052934; -.
DR   InParanoid; P31257; -.
DR   KO; K17444; -.
DR   OMA; CPRNVTP; -.
DR   OrthoDB; EOG091G0LON; -.
DR   PhylomeDB; P31257; -.
DR   TreeFam; TF317819; -.
DR   PRO; PR:P31257; -.
DR   Proteomes; UP000000589; Chromosome 15.
DR   Bgee; ENSMUSG00000022484; -.
DR   CleanEx; MM_HOXC10; -.
DR   Genevisible; P31257; MM.
DR   GO; GO:0019907; C:cyclin-dependent protein kinase activating kinase holoenzyme complex; IEA:Ensembl.
DR   GO; GO:0016604; C:nuclear body; ISO:MGI.
DR   GO; GO:0000977; F:RNA polymerase II regulatory region sequence-specific DNA binding; ISO:MGI.
DR   GO; GO:0001228; F:transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding; ISO:MGI.
DR   GO; GO:0009952; P:anterior/posterior pattern specification; IGI:MGI.
DR   GO; GO:0030326; P:embryonic limb morphogenesis; IGI:MGI.
DR   GO; GO:0050905; P:neuromuscular process; IGI:MGI.
DR   GO; GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; ISO:MGI.
DR   GO; GO:0009954; P:proximal/distal pattern formation; IGI:MGI.
DR   GO; GO:0001501; P:skeletal system development; IGI:MGI.
DR   GO; GO:0021520; P:spinal cord motor neuron cell fate specification; IGI:MGI.
DR   InterPro; IPR009057; Homeobox-like.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR020479; Homeobox_metazoa.
DR   Pfam; PF00046; Homeobox; 1.
DR   PRINTS; PR00024; HOMEOBOX.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
PE   2: Evidence at transcript level;
KW   Complete proteome; Developmental protein; DNA-binding; Homeobox;
KW   Isopeptide bond; Nucleus; Phosphoprotein; Reference proteome;
KW   Transcription; Transcription regulation; Ubl conjugation.
FT   CHAIN         1    342       Homeobox protein Hox-C10.
FT                                /FTId=PRO_0000200191.
FT   DNA_BIND    268    327       Homeobox. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00108}.
FT   MOD_RES       8      8       Phosphothreonine.
FT                                {ECO:0000250|UniProtKB:Q9NYD6}.
FT   MOD_RES     189    189       Phosphoserine.
FT                                {ECO:0000250|UniProtKB:Q9NYD6}.
FT   CROSSLNK    254    254       Glycyl lysine isopeptide (Lys-Gly)
FT                                (interchain with G-Cter in SUMO2).
FT                                {ECO:0000250|UniProtKB:Q9NYD6}.
FT   CONFLICT    182    182       P -> S (in Ref. 2; AAH53405).
FT                                {ECO:0000305}.
SQ   SEQUENCE   342 AA;  38196 MW;  7BB2E117A768F52B CRC64;
     MTCPRNVTPN SYAEPLAAPG GGERYNRNAG MYMQSGSDFN CGVMRGCGLA PSLSKRDEGG
     SPNLALNTYP SYLSQLDSWG DPKAAYRLEQ PVGRPLSSCS YPPSVKEENV CCMYSAEKRA
     KSGPEAALYS HPLPESCLGE HEVPVPSYYR ASPSYSALDK TPHCAGANEF EAPFEQRASL
     NPRTEHLESP QLGGKVSFPE TPKSDSQTPS PNEIKTEQSL AGPKASPSES EKERAKTADS
     SPDTSDNEAK EEIKAENTTG NWLTAKSGRK KRCPYTKHQT LELEKEFLFN MYLTRERRLE
     ISKTINLTDR QVKIWFQNRR MKLKKMNREN RIRELTSNFN FT
//
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