ID HXC10_MOUSE Reviewed; 342 AA.
AC P31257; P31312; Q7TMT7;
DT 01-JUL-1993, integrated into UniProtKB/Swiss-Prot.
DT 01-JUL-1993, sequence version 1.
DT 28-MAR-2018, entry version 147.
DE RecName: Full=Homeobox protein Hox-C10;
DE AltName: Full=Homeobox protein Hox-3.6;
GN Name=Hoxc10; Synonyms=Hox-3.6, Hoxc-10;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
OC Muroidea; Muridae; Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=CD-1;
RX PubMed=1353983; DOI=10.1016/0925-4773(92)90077-W;
RA Peterson R.L., Jacobs D.F., Awgulewitsch A.;
RT "Hox-3.6: isolation and characterization of a new murine homeobox gene
RT located in the 5' region of the Hox-3 cluster.";
RL Mech. Dev. 37:151-166(1992).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C3H/He; TISSUE=Mesenchymal stem cell;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE OF 268-327.
RX PubMed=1683707; DOI=10.1073/pnas.88.23.10706;
RA Singh G., Kaur S., Stock J.L., Jenkins N.A., Gilbert D.J.,
RA Copeland N.G., Potter S.S.;
RT "Identification of 10 murine homeobox genes.";
RL Proc. Natl. Acad. Sci. U.S.A. 88:10706-10710(1991).
RN [4]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 289-313.
RX PubMed=1720547; DOI=10.1073/pnas.88.23.10711;
RA Murtha M.T., Leckman J.F., Ruddle F.H.;
RT "Detection of homeobox genes in development and evolution.";
RL Proc. Natl. Acad. Sci. U.S.A. 88:10711-10715(1991).
CC -!- FUNCTION: Sequence-specific transcription factor which is part of
CC a developmental regulatory system that provides cells with
CC specific positional identities on the anterior-posterior axis.
CC -!- SUBCELLULAR LOCATION: Nucleus.
CC -!- SIMILARITY: Belongs to the Abd-B homeobox family. {ECO:0000305}.
DR EMBL; X63507; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC053405; AAH53405.1; -; mRNA.
DR EMBL; M81658; AAA63310.1; -; Genomic_DNA.
DR CCDS; CCDS57014.1; -.
DR PIR; A56552; A56552.
DR RefSeq; NP_034592.2; NM_010462.5.
DR UniGene; Mm.31665; -.
DR ProteinModelPortal; P31257; -.
DR SMR; P31257; -.
DR STRING; 10090.ENSMUSP00000001699; -.
DR PhosphoSitePlus; P31257; -.
DR MaxQB; P31257; -.
DR PaxDb; P31257; -.
DR PRIDE; P31257; -.
DR Ensembl; ENSMUST00000001699; ENSMUSP00000001699; ENSMUSG00000022484.
DR GeneID; 209448; -.
DR KEGG; mmu:209448; -.
DR UCSC; uc007xwz.2; mouse.
DR CTD; 3226; -.
DR MGI; MGI:96192; Hoxc10.
DR eggNOG; KOG0487; Eukaryota.
DR eggNOG; ENOG4111FJP; LUCA.
DR GeneTree; ENSGT00910000143984; -.
DR HOGENOM; HOG000231182; -.
DR HOVERGEN; HBG052934; -.
DR InParanoid; P31257; -.
DR KO; K17444; -.
DR OMA; CPRNVTP; -.
DR OrthoDB; EOG091G0LON; -.
DR PhylomeDB; P31257; -.
DR TreeFam; TF317819; -.
DR PRO; PR:P31257; -.
DR Proteomes; UP000000589; Chromosome 15.
DR Bgee; ENSMUSG00000022484; -.
DR CleanEx; MM_HOXC10; -.
DR Genevisible; P31257; MM.
DR GO; GO:0019907; C:cyclin-dependent protein kinase activating kinase holoenzyme complex; IEA:Ensembl.
DR GO; GO:0016604; C:nuclear body; ISO:MGI.
DR GO; GO:0005654; C:nucleoplasm; ISO:MGI.
DR GO; GO:0000977; F:RNA polymerase II regulatory region sequence-specific DNA binding; ISO:MGI.
DR GO; GO:0001228; F:transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding; ISO:MGI.
DR GO; GO:0009952; P:anterior/posterior pattern specification; IGI:MGI.
DR GO; GO:0030326; P:embryonic limb morphogenesis; IGI:MGI.
DR GO; GO:0050905; P:neuromuscular process; IGI:MGI.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; ISO:MGI.
DR GO; GO:0009954; P:proximal/distal pattern formation; IGI:MGI.
DR GO; GO:0001501; P:skeletal system development; IGI:MGI.
DR GO; GO:0021520; P:spinal cord motor neuron cell fate specification; IGI:MGI.
DR CDD; cd00086; homeodomain; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR020479; Homeobox_metazoa.
DR Pfam; PF00046; Homeobox; 1.
DR PRINTS; PR00024; HOMEOBOX.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; SSF46689; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 2: Evidence at transcript level;
KW Complete proteome; Developmental protein; DNA-binding; Homeobox;
KW Isopeptide bond; Nucleus; Phosphoprotein; Reference proteome;
KW Transcription; Transcription regulation; Ubl conjugation.
FT CHAIN 1 342 Homeobox protein Hox-C10.
FT /FTId=PRO_0000200191.
FT DNA_BIND 268 327 Homeobox. {ECO:0000255|PROSITE-
FT ProRule:PRU00108}.
FT MOD_RES 8 8 Phosphothreonine.
FT {ECO:0000250|UniProtKB:Q9NYD6}.
FT MOD_RES 189 189 Phosphoserine.
FT {ECO:0000250|UniProtKB:Q9NYD6}.
FT CROSSLNK 106 106 Glycyl lysine isopeptide (Lys-Gly)
FT (interchain with G-Cter in SUMO2).
FT {ECO:0000250|UniProtKB:Q9NYD6}.
FT CROSSLNK 195 195 Glycyl lysine isopeptide (Lys-Gly)
FT (interchain with G-Cter in SUMO2).
FT {ECO:0000250|UniProtKB:Q9NYD6}.
FT CROSSLNK 254 254 Glycyl lysine isopeptide (Lys-Gly)
FT (interchain with G-Cter in SUMO2).
FT {ECO:0000250|UniProtKB:Q9NYD6}.
FT CONFLICT 182 182 P -> S (in Ref. 2; AAH53405).
FT {ECO:0000305}.
SQ SEQUENCE 342 AA; 38196 MW; 7BB2E117A768F52B CRC64;
MTCPRNVTPN SYAEPLAAPG GGERYNRNAG MYMQSGSDFN CGVMRGCGLA PSLSKRDEGG
SPNLALNTYP SYLSQLDSWG DPKAAYRLEQ PVGRPLSSCS YPPSVKEENV CCMYSAEKRA
KSGPEAALYS HPLPESCLGE HEVPVPSYYR ASPSYSALDK TPHCAGANEF EAPFEQRASL
NPRTEHLESP QLGGKVSFPE TPKSDSQTPS PNEIKTEQSL AGPKASPSES EKERAKTADS
SPDTSDNEAK EEIKAENTTG NWLTAKSGRK KRCPYTKHQT LELEKEFLFN MYLTRERRLE
ISKTINLTDR QVKIWFQNRR MKLKKMNREN RIRELTSNFN FT
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