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Database: UniProt
Entry: P34575
LinkDB: P34575
Original site: P34575 
ID   CISY_CAEEL              Reviewed;         468 AA.
AC   P34575;
DT   01-FEB-1994, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1994, sequence version 1.
DT   26-NOV-2014, entry version 106.
DE   RecName: Full=Probable citrate synthase, mitochondrial;
DE            EC=2.3.3.16;
DE   Flags: Precursor;
GN   Name=cts-1; ORFNames=T20G5.2;
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for
RT   investigating biology.";
RL   Science 282:2012-2018(1998).
CC   -!- CATALYTIC ACTIVITY: Acetyl-CoA + H(2)O + oxaloacetate = citrate +
CC       CoA. {ECO:0000255|PROSITE-ProRule:PRU10117}.
CC   -!- PATHWAY: Carbohydrate metabolism; tricarboxylic acid cycle;
CC       isocitrate from oxaloacetate: step 1/2.
CC   -!- SUBUNIT: Homodimer. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion matrix {ECO:0000250}.
CC   -!- MISCELLANEOUS: Citrate synthase is found in nearly all cells
CC       capable of oxidative metabolism.
CC   -!- SIMILARITY: Belongs to the citrate synthase family. {ECO:0000305}.
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DR   EMBL; Z30423; CAA83004.1; -; Genomic_DNA.
DR   PIR; S42370; S42370.
DR   RefSeq; NP_499264.1; NM_066863.6.
DR   UniGene; Cel.17843; -.
DR   ProteinModelPortal; P34575; -.
DR   SMR; P34575; 32-462.
DR   STRING; 6239.T20G5.2.2; -.
DR   World-2DPAGE; 0020:P34575; -.
DR   PaxDb; P34575; -.
DR   EnsemblMetazoa; T20G5.2; T20G5.2; WBGene00000833.
DR   GeneID; 176437; -.
DR   KEGG; cel:CELE_T20G5.2; -.
DR   UCSC; T20G5.2.1; c. elegans.
DR   CTD; 176437; -.
DR   WormBase; T20G5.2; CE00513; WBGene00000833; cts-1.
DR   eggNOG; COG0372; -.
DR   GeneTree; ENSGT00390000006813; -.
DR   HOGENOM; HOG000130831; -.
DR   InParanoid; P34575; -.
DR   KO; K01647; -.
DR   OMA; ELIYEDC; -.
DR   PhylomeDB; P34575; -.
DR   Reactome; REACT_232421; Citric acid cycle (TCA cycle).
DR   UniPathway; UPA00223; UER00717.
DR   NextBio; 892576; -.
DR   PRO; PR:P34575; -.
DR   GO; GO:0005759; C:mitochondrial matrix; ISS:UniProtKB.
DR   GO; GO:0005739; C:mitochondrion; IDA:WormBase.
DR   GO; GO:0004108; F:citrate (Si)-synthase activity; ISS:UniProtKB.
DR   GO; GO:0005975; P:carbohydrate metabolic process; ISS:UniProtKB.
DR   GO; GO:0044262; P:cellular carbohydrate metabolic process; IEA:InterPro.
DR   GO; GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-UniPathway.
DR   Gene3D; 1.10.580.10; -; 1.
DR   InterPro; IPR016142; Citrate_synth-like_lrg_a-sub.
DR   InterPro; IPR002020; Citrate_synthase-like.
DR   InterPro; IPR016141; Citrate_synthase-like_core.
DR   InterPro; IPR019810; Citrate_synthase_AS.
DR   InterPro; IPR010109; Citrate_synthase_euk.
DR   PANTHER; PTHR11739; PTHR11739; 1.
DR   Pfam; PF00285; Citrate_synt; 1.
DR   PRINTS; PR00143; CITRTSNTHASE.
DR   SUPFAM; SSF48256; SSF48256; 1.
DR   TIGRFAMs; TIGR01793; cit_synth_euk; 1.
DR   PROSITE; PS00480; CITRATE_SYNTHASE; 1.
PE   1: Evidence at protein level;
KW   Complete proteome; Mitochondrion; Reference proteome; Transferase;
KW   Transit peptide; Tricarboxylic acid cycle.
FT   TRANSIT       1      ?       Mitochondrion. {ECO:0000255}.
FT   CHAIN         ?    468       Probable citrate synthase, mitochondrial.
FT                                /FTId=PRO_0000005470.
FT   ACT_SITE    303    303       {ECO:0000255|PROSITE-ProRule:PRU10117}.
FT   ACT_SITE    349    349       {ECO:0000255|PROSITE-ProRule:PRU10117}.
FT   ACT_SITE    404    404       {ECO:0000255|PROSITE-ProRule:PRU10117}.
SQ   SEQUENCE   468 AA;  51540 MW;  CDE40CCA5729B9EA CRC64;
     MSLSGMAIRR LITKGVIPVC QVAPLSTSAE GSTNLKEVLS KKIPAHNAKV KSFRTEHGST
     VVQNVNIDMI YGGMRSMKGM VTETSVLDPE EGIRFRGYSI PECQKLLPKA KGGEEPLPEA
     IWWLLCTGDV PSEAQTAAIT KEWNARADLP THVVRMLDNF PDNLHPMAQF IAAIAALNNE
     SKFAGAYARG VAKASYWEYA YEDSMDLLAK LPTVAAIIYR NLYRDGSAVS VIDPKKDWSA
     NFSSMLGYDD PLFAELMRLY LVIHSDHEGG NVSAHTSHLV GSALSDPYLS FSAAMAGLAG
     PLHGLANQEV LVFLNKIVGE IGFNYTEEQL KEWVWKHLKS GQVVPGYGHA VLRKTDPRYE
     CQREFALKHL PNDDLFKLVS TLYKITPGIL LEQGKAKNPW PNVDSHSGVL LQYFGMTEMS
     FYTVLFGVSR ALGCLSQLIW ARGMGLPLER PKSHSTDGLI KLALAAKK
//
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