ID CISY_CAEEL Reviewed; 468 AA.
AC P34575;
DT 01-FEB-1994, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1994, sequence version 1.
DT 01-MAY-2013, entry version 99.
DE RecName: Full=Probable citrate synthase, mitochondrial;
DE EC=2.3.3.1;
DE Flags: Precursor;
GN Name=cts-1; ORFNames=T20G5.2;
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for
RT investigating biology.";
RL Science 282:2012-2018(1998).
CC -!- CATALYTIC ACTIVITY: Acetyl-CoA + H(2)O + oxaloacetate = citrate +
CC CoA.
CC -!- PATHWAY: Carbohydrate metabolism; tricarboxylic acid cycle;
CC isocitrate from oxaloacetate: step 1/2.
CC -!- SUBUNIT: Homodimer (By similarity).
CC -!- SUBCELLULAR LOCATION: Mitochondrion matrix (By similarity).
CC -!- MISCELLANEOUS: Citrate synthase is found in nearly all cells
CC capable of oxidative metabolism.
CC -!- SIMILARITY: Belongs to the citrate synthase family.
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DR EMBL; Z30423; CAA83004.1; -; Genomic_DNA.
DR PIR; S42370; S42370.
DR RefSeq; NP_499264.1; NM_066863.6.
DR ProteinModelPortal; P34575; -.
DR SMR; P34575; 32-462.
DR STRING; 6239.T20G5.2.2; -.
DR World-2DPAGE; 0020:P34575; -.
DR PaxDb; P34575; -.
DR EnsemblMetazoa; T20G5.2.1; T20G5.2.1; T20G5.2.
DR EnsemblMetazoa; T20G5.2.2; T20G5.2.2; T20G5.2.
DR GeneID; 176437; -.
DR KEGG; cel:CELE_T20G5.2; -.
DR UCSC; T20G5.2.1; c. elegans.
DR CTD; 176437; -.
DR WormBase; T20G5.2; CE00513; WBGene00000833; cts-1.
DR eggNOG; COG0372; -.
DR GeneTree; ENSGT00390000006813; -.
DR HOGENOM; HOG000130831; -.
DR InParanoid; P34575; -.
DR KO; K01647; -.
DR OMA; ELIYEDC; -.
DR UniPathway; UPA00223; UER00717.
DR NextBio; 892576; -.
DR GO; GO:0005759; C:mitochondrial matrix; ISS:UniProtKB.
DR GO; GO:0004108; F:citrate (Si)-synthase activity; ISS:UniProtKB.
DR GO; GO:0005975; P:carbohydrate metabolic process; ISS:UniProtKB.
DR GO; GO:0044262; P:cellular carbohydrate metabolic process; IEA:InterPro.
DR GO; GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-UniPathway.
DR Gene3D; 1.10.580.10; -; 1.
DR InterPro; IPR016142; Citrate_synth-like_lrg_a-sub.
DR InterPro; IPR002020; Citrate_synthase-like.
DR InterPro; IPR016141; Citrate_synthase-like_core.
DR InterPro; IPR019810; Citrate_synthase_AS.
DR InterPro; IPR010109; Citrate_synthase_euk.
DR PANTHER; PTHR11739; PTHR11739; 1.
DR Pfam; PF00285; Citrate_synt; 1.
DR PRINTS; PR00143; CITRTSNTHASE.
DR SUPFAM; SSF48256; Citrate_synthase_core; 1.
DR TIGRFAMs; TIGR01793; cit_synth_euk; 1.
DR PROSITE; PS00480; CITRATE_SYNTHASE; 1.
PE 1: Evidence at protein level;
KW Complete proteome; Mitochondrion; Reference proteome; Transferase;
KW Transit peptide; Tricarboxylic acid cycle.
FT TRANSIT 1 ? Mitochondrion (Potential).
FT CHAIN ? 468 Probable citrate synthase, mitochondrial.
FT /FTId=PRO_0000005470.
FT ACT_SITE 303 303 By similarity.
FT ACT_SITE 349 349 By similarity.
FT ACT_SITE 404 404 By similarity.
SQ SEQUENCE 468 AA; 51540 MW; CDE40CCA5729B9EA CRC64;
MSLSGMAIRR LITKGVIPVC QVAPLSTSAE GSTNLKEVLS KKIPAHNAKV KSFRTEHGST
VVQNVNIDMI YGGMRSMKGM VTETSVLDPE EGIRFRGYSI PECQKLLPKA KGGEEPLPEA
IWWLLCTGDV PSEAQTAAIT KEWNARADLP THVVRMLDNF PDNLHPMAQF IAAIAALNNE
SKFAGAYARG VAKASYWEYA YEDSMDLLAK LPTVAAIIYR NLYRDGSAVS VIDPKKDWSA
NFSSMLGYDD PLFAELMRLY LVIHSDHEGG NVSAHTSHLV GSALSDPYLS FSAAMAGLAG
PLHGLANQEV LVFLNKIVGE IGFNYTEEQL KEWVWKHLKS GQVVPGYGHA VLRKTDPRYE
CQREFALKHL PNDDLFKLVS TLYKITPGIL LEQGKAKNPW PNVDSHSGVL LQYFGMTEMS
FYTVLFGVSR ALGCLSQLIW ARGMGLPLER PKSHSTDGLI KLALAAKK
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