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Database: UniProt
Entry: P34970
LinkDB: P34970
Original site: P34970 
ID   AA1R_RABIT              Reviewed;         328 AA.
AC   P34970;
DT   01-FEB-1994, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1994, sequence version 1.
DT   29-OCT-2014, entry version 89.
DE   RecName: Full=Adenosine receptor A1;
GN   Name=ADORA1;
OS   Oryctolagus cuniculus (Rabbit).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae;
OC   Oryctolagus.
OX   NCBI_TaxID=9986;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Kidney;
RX   PubMed=8514195; DOI=10.1016/0378-1119(93)90576-O;
RA   Bhattacharya S., Dewitt D.L., Burnatowska-Hledin M., Smith W.L.,
RA   Spielman W.S.;
RT   "Cloning of an adenosine A1 receptor-encoding gene from rabbit.";
RL   Gene 128:285-288(1993).
CC   -!- FUNCTION: Receptor for adenosine. The activity of this receptor is
CC       mediated by G proteins which inhibit adenylyl cyclase.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC       {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR   EMBL; L01700; AAA31148.1; -; mRNA.
DR   PIR; JN0675; JN0675.
DR   RefSeq; NP_001164544.1; NM_001171073.1.
DR   UniGene; Ocu.7475; -.
DR   ProteinModelPortal; P34970; -.
DR   STRING; 9986.ENSOCUP00000009475; -.
DR   BindingDB; P34970; -.
DR   GeneID; 100328615; -.
DR   CTD; 134; -.
DR   eggNOG; NOG284456; -.
DR   HOGENOM; HOG000015770; -.
DR   HOVERGEN; HBG106962; -.
DR   InParanoid; P34970; -.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR   GO; GO:0001609; F:G-protein coupled adenosine receptor activity; IEA:InterPro.
DR   GO; GO:0050728; P:negative regulation of inflammatory response; IEA:Ensembl.
DR   GO; GO:0002686; P:negative regulation of leukocyte migration; IEA:Ensembl.
DR   GO; GO:0070256; P:negative regulation of mucus secretion; IEA:Ensembl.
DR   GO; GO:0060079; P:regulation of excitatory postsynaptic membrane potential; IEA:Ensembl.
DR   GO; GO:0003093; P:regulation of glomerular filtration; IEA:Ensembl.
DR   GO; GO:0051930; P:regulation of sensory perception of pain; IEA:Ensembl.
DR   Gene3D; 1.20.1070.10; -; 1.
DR   InterPro; IPR001068; Adeno_A1_rcpt.
DR   InterPro; IPR001634; Adenosn_rcpt.
DR   InterPro; IPR000276; GPCR_Rhodpsn.
DR   InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR   Pfam; PF00001; 7tm_1; 1.
DR   PRINTS; PR00552; ADENOSINEA1R.
DR   PRINTS; PR00424; ADENOSINER.
DR   PRINTS; PR00237; GPCRRHODOPSN.
DR   PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; Complete proteome; Disulfide bond;
KW   G-protein coupled receptor; Glycoprotein; Lipoprotein; Membrane;
KW   Palmitate; Receptor; Reference proteome; Transducer; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN         1    328       Adenosine receptor A1.
FT                                /FTId=PRO_0000068993.
FT   TOPO_DOM      1     10       Extracellular. {ECO:0000255}.
FT   TRANSMEM     11     33       Helical; Name=1. {ECO:0000255}.
FT   TOPO_DOM     34     46       Cytoplasmic. {ECO:0000255}.
FT   TRANSMEM     47     69       Helical; Name=2. {ECO:0000255}.
FT   TOPO_DOM     70     80       Extracellular. {ECO:0000255}.
FT   TRANSMEM     81    102       Helical; Name=3. {ECO:0000255}.
FT   TOPO_DOM    103    123       Cytoplasmic. {ECO:0000255}.
FT   TRANSMEM    124    146       Helical; Name=4. {ECO:0000255}.
FT   TOPO_DOM    147    176       Extracellular. {ECO:0000255}.
FT   TRANSMEM    177    201       Helical; Name=5. {ECO:0000255}.
FT   TOPO_DOM    202    235       Cytoplasmic. {ECO:0000255}.
FT   TRANSMEM    236    259       Helical; Name=6. {ECO:0000255}.
FT   TOPO_DOM    260    267       Extracellular. {ECO:0000255}.
FT   TRANSMEM    268    292       Helical; Name=7. {ECO:0000255}.
FT   TOPO_DOM    293    328       Cytoplasmic. {ECO:0000255}.
FT   LIPID       309    309       S-palmitoyl cysteine. {ECO:0000255}.
FT   CARBOHYD    159    159       N-linked (GlcNAc...). {ECO:0000255}.
FT   DISULFID     80    169       {ECO:0000255|PROSITE-ProRule:PRU00521}.
SQ   SEQUENCE   328 AA;  36556 MW;  0F9B53E6AEC25968 CRC64;
     MPPSISAFQA AYIGIEVLIA LVSVPGNVLV IWAVKVNQAL RDATFCFIVS LAVADVAVGA
     LVIPLAILIN IGPETYFHTC LMVACPVLIL TQSSILALLA IAVDRYLRVK IPLRYKAVVT
     PRRAAVAIAG CWILSLVVGL TPMFGWNNLR EVQRAWAANG SVGEPVIKCE FEKVISMEYM
     VYFNFFVWVL PPLLLMVLIY LEVFYLIRRQ LSKKASASSG DPHKYYGKEL KIAKSLALIL
     FLFALSWLPL HILNCVTLFC PSCQKPSILV YTAIFLTHGN SAMNPIVYAF RIHKFRVTFL
     KIWNDHFRCR PAPAGDGDED LPEEKPND
//
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