ID AA1R_RABIT Reviewed; 328 AA.
AC P34970;
DT 01-FEB-1994, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1994, sequence version 1.
DT 03-APR-2013, entry version 82.
DE RecName: Full=Adenosine receptor A1;
GN Name=ADORA1;
OS Oryctolagus cuniculus (Rabbit).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae;
OC Oryctolagus.
OX NCBI_TaxID=9986;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Kidney;
RX PubMed=8514195; DOI=10.1016/0378-1119(93)90576-O;
RA Bhattacharya S., Dewitt D.L., Burnatowska-Hledin M., Smith W.L.,
RA Spielman W.S.;
RT "Cloning of an adenosine A1 receptor-encoding gene from rabbit.";
RL Gene 128:285-288(1993).
CC -!- FUNCTION: Receptor for adenosine. The activity of this receptor is
CC mediated by G proteins which inhibit adenylyl cyclase.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
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DR EMBL; L01700; AAA31148.1; -; mRNA.
DR PIR; JN0675; JN0675.
DR RefSeq; NP_001164544.1; NM_001171073.1.
DR UniGene; Ocu.7475; -.
DR ProteinModelPortal; P34970; -.
DR STRING; 9986.ENSOCUP00000009475; -.
DR GeneID; 100328615; -.
DR eggNOG; NOG284456; -.
DR HOGENOM; HOG000015770; -.
DR HOVERGEN; HBG106962; -.
DR OrthoDB; EOG4BVRV7; -.
DR BindingDB; P34970; -.
DR ChEMBL; CHEMBL3947; -.
DR GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0001609; F:G-protein coupled adenosine receptor activity; IEA:InterPro.
DR GO; GO:0050728; P:negative regulation of inflammatory response; IEA:Compara.
DR GO; GO:0002686; P:negative regulation of leukocyte migration; IEA:Compara.
DR GO; GO:0070256; P:negative regulation of mucus secretion; IEA:Compara.
DR GO; GO:0060079; P:regulation of excitatory postsynaptic membrane potential; IEA:Compara.
DR GO; GO:0003093; P:regulation of glomerular filtration; IEA:Compara.
DR InterPro; IPR001068; Adeno_A1_rcpt.
DR InterPro; IPR001634; Adenosn_rcpt.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR00552; ADENOSINEA1R.
DR PRINTS; PR00424; ADENOSINER.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Complete proteome; Disulfide bond;
KW G-protein coupled receptor; Glycoprotein; Lipoprotein; Membrane;
KW Palmitate; Receptor; Reference proteome; Transducer; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1 328 Adenosine receptor A1.
FT /FTId=PRO_0000068993.
FT TOPO_DOM 1 10 Extracellular (Potential).
FT TRANSMEM 11 33 Helical; Name=1; (Potential).
FT TOPO_DOM 34 46 Cytoplasmic (Potential).
FT TRANSMEM 47 69 Helical; Name=2; (Potential).
FT TOPO_DOM 70 80 Extracellular (Potential).
FT TRANSMEM 81 102 Helical; Name=3; (Potential).
FT TOPO_DOM 103 123 Cytoplasmic (Potential).
FT TRANSMEM 124 146 Helical; Name=4; (Potential).
FT TOPO_DOM 147 176 Extracellular (Potential).
FT TRANSMEM 177 201 Helical; Name=5; (Potential).
FT TOPO_DOM 202 235 Cytoplasmic (Potential).
FT TRANSMEM 236 259 Helical; Name=6; (Potential).
FT TOPO_DOM 260 267 Extracellular (Potential).
FT TRANSMEM 268 292 Helical; Name=7; (Potential).
FT TOPO_DOM 293 328 Cytoplasmic (Potential).
FT LIPID 309 309 S-palmitoyl cysteine (Potential).
FT CARBOHYD 159 159 N-linked (GlcNAc...) (Potential).
FT DISULFID 80 169 By similarity.
SQ SEQUENCE 328 AA; 36556 MW; 0F9B53E6AEC25968 CRC64;
MPPSISAFQA AYIGIEVLIA LVSVPGNVLV IWAVKVNQAL RDATFCFIVS LAVADVAVGA
LVIPLAILIN IGPETYFHTC LMVACPVLIL TQSSILALLA IAVDRYLRVK IPLRYKAVVT
PRRAAVAIAG CWILSLVVGL TPMFGWNNLR EVQRAWAANG SVGEPVIKCE FEKVISMEYM
VYFNFFVWVL PPLLLMVLIY LEVFYLIRRQ LSKKASASSG DPHKYYGKEL KIAKSLALIL
FLFALSWLPL HILNCVTLFC PSCQKPSILV YTAIFLTHGN SAMNPIVYAF RIHKFRVTFL
KIWNDHFRCR PAPAGDGDED LPEEKPND
//
