ID CHIT_STRLI Reviewed; 619 AA.
AC P36909;
DT 01-JUN-1994, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-1994, sequence version 1.
DT 01-MAY-2013, entry version 87.
DE RecName: Full=Chitinase C;
DE EC=3.2.1.14;
DE Flags: Precursor;
GN Name=chiC;
OS Streptomyces lividans.
OC Bacteria; Actinobacteria; Actinobacteridae; Actinomycetales;
OC Streptomycineae; Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1916;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=8515228;
RA Fujii T., Miyashita K.;
RT "Multiple domain structure in a chitinase gene (chiC) of Streptomyces
RT lividans.";
RL J. Gen. Microbiol. 139:677-686(1993).
CC -!- CATALYTIC ACTIVITY: Random hydrolysis of N-acetyl-beta-D-
CC glucosaminide (1->4)-beta-linkages in chitin and chitodextrins.
CC -!- INDUCTION: By chitin.
CC -!- SIMILARITY: Belongs to the glycosyl hydrolase 18 family. Chitinase
CC class II subfamily.
CC -!- SIMILARITY: Contains 1 CBM2 (carbohydrate binding type-2) domain.
CC -!- SIMILARITY: Contains 1 fibronectin type-III domain.
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DR EMBL; D12647; BAA02168.1; -; Genomic_DNA.
DR ProteinModelPortal; P36909; -.
DR CAZy; CBM2; Carbohydrate-Binding Module Family 2.
DR CAZy; GH18; Glycoside Hydrolase Family 18.
DR GO; GO:0008061; F:chitin binding; IEA:UniProtKB-KW.
DR GO; GO:0004568; F:chitinase activity; IEA:EC.
DR GO; GO:0030247; F:polysaccharide binding; IEA:InterPro.
DR GO; GO:0006032; P:chitin catabolic process; IEA:UniProtKB-KW.
DR GO; GO:0000272; P:polysaccharide catabolic process; IEA:UniProtKB-KW.
DR Gene3D; 2.60.40.10; -; 1.
DR Gene3D; 2.60.40.290; -; 1.
DR Gene3D; 3.20.20.80; -; 2.
DR InterPro; IPR008965; Carb-bd_dom.
DR InterPro; IPR012291; CBD_carb-bd_dom.
DR InterPro; IPR018366; CBM2_CS.
DR InterPro; IPR001919; Cellulose-bd_dom_fam2_bac.
DR InterPro; IPR011583; Chitinase_II.
DR InterPro; IPR003961; Fibronectin_type3.
DR InterPro; IPR001223; Glyco_hydro18cat.
DR InterPro; IPR001579; Glyco_hydro_18_chit_AS.
DR InterPro; IPR013781; Glyco_hydro_catalytic_dom.
DR InterPro; IPR017853; Glycoside_hydrolase_SF.
DR InterPro; IPR013783; Ig-like_fold.
DR Pfam; PF00553; CBM_2; 1.
DR Pfam; PF00041; fn3; 1.
DR Pfam; PF00704; Glyco_hydro_18; 1.
DR SMART; SM00637; CBD_II; 1.
DR SMART; SM00060; FN3; 1.
DR SMART; SM00636; Glyco_18; 1.
DR SUPFAM; SSF49384; Cellul_bind; 1.
DR SUPFAM; SSF49265; FN_III-like; 1.
DR SUPFAM; SSF51445; Glyco_hydro_cat; 1.
DR PROSITE; PS51173; CBM2; 1.
DR PROSITE; PS00561; CBM2_A; 1.
DR PROSITE; PS01095; CHITINASE_18; 1.
DR PROSITE; PS00018; EF_HAND_1; UNKNOWN_1.
DR PROSITE; PS50853; FN3; 1.
PE 2: Evidence at transcript level;
KW Carbohydrate metabolism; Chitin degradation; Chitin-binding;
KW Glycosidase; Hydrolase; Polysaccharide degradation; Signal.
FT SIGNAL 1 30 Potential.
FT CHAIN 31 619 Chitinase C.
FT /FTId=PRO_0000011911.
FT DOMAIN 31 134 CBM2.
FT DOMAIN 142 224 Fibronectin type-III.
FT REGION 240 619 Catalytic.
FT ACT_SITE 382 382 Proton donor (By similarity).
SQ SEQUENCE 619 AA; 65200 MW; A23CEE5B3C5D6F21 CRC64;
MRFRHKAAAL AATLALPLAG LVGLASPAQA ATSATATFAK TSDWGTGFGG SWTVKNTGTT
SLSSWTVEWD FPTGTKVTSA WDATVTNSGD HWTAKNVGWN GTLAPGASVS FGFNGSGPGS
PSNCKLNGGS CDGTSVPGDA APSAPGTPTA SNITDTSVKL SWSAATDDKG VKNYDVLRDG
AKVATVTGTT YTDNGLTKGT AYSYSVKARD TADQTGPASG AVKVTTTGGG DGGNPGTGAE
VKMGYFTNWG VYGRNYHVKN LVTSGSADKI THINYAFGNV QGGKCTIGDS YADYDKAYTA
DQSVDGVADT WDQPLRGNFN QLRKLKAKYP NIKILYSFGG WTWSGGFPDA VKNPAAFAKS
CHDLVEDPRW ADVFDGIDLD WEYPNACGLS CDETSAPNAF SSMMKAMRAE FGQDYLITAA
VTADGSDGGK IDAADYGEAS KYIDWYNVMT YDFFGAWAKN GPTAPHSPLT AYDGIPQQGF
NTADAMAKFK SKGVPADKLL IGIGFYGRGW TGVTQSAPGG TATGPATGTY EAGIEDYKVL
KNSCPATGTI AGTAYAHCGS NWWSYDTPAT IKSKMDWAEQ QGLGGAFFWE FSGDTANGDW
WRHRQRPQVT PAVRTTRRH
//
