ID TLPC_BACSU Reviewed; 573 AA.
AC P39209;
DT 01-FEB-1995, integrated into UniProtKB/Swiss-Prot.
DT 16-JUN-2009, sequence version 3.
DT 27-MAR-2024, entry version 142.
DE RecName: Full=Methyl-accepting chemotaxis protein TlpC;
GN Name=tlpC; OrderedLocusNames=BSU03440;
OS Bacillus subtilis (strain 168).
OC Bacteria; Bacillota; Bacilli; Bacillales; Bacillaceae; Bacillus.
OX NCBI_TaxID=224308;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=168 / OI1085;
RX PubMed=7921238; DOI=10.1099/13500872-140-8-1847;
RA Hanlon D.W., Rosario M.M.L., Ordal G.W., Venema G., van Sinderen D.;
RT "Identification of TlpC, a novel 62 kDa MCP-like protein from Bacillus
RT subtilis.";
RL Microbiology 140:1847-1854(1994).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=168;
RX PubMed=7704255; DOI=10.1099/13500872-141-2-277;
RA Fujishima Y., Yamane K.;
RT "A 10 kb nucleotide sequence at the 5' flanking region (32 degrees) of
RT srfAA of the Bacillus subtilis chromosome.";
RL Microbiology 141:277-279(1995).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=168;
RX PubMed=8969502; DOI=10.1099/13500872-142-11-3047;
RA Yamane K., Kumano M., Kurita K.;
RT "The 25 degrees-36 degrees region of the Bacillus subtilis chromosome:
RT determination of the sequence of a 146 kb segment and identification of 113
RT genes.";
RL Microbiology 142:3047-3056(1996).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=168;
RX PubMed=9384377; DOI=10.1038/36786;
RA Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V.,
RA Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R.,
RA Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S.,
RA Bruschi C.V., Caldwell B., Capuano V., Carter N.M., Choi S.-K.,
RA Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F.,
RA Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D.,
RA Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M.,
RA Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P.,
RA Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K.,
RA Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S.,
RA Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y.,
RA Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G.,
RA Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J.,
RA Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C.,
RA Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S.,
RA Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B.,
RA Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S.,
RA Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M.,
RA Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y.,
RA Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J.,
RA Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A.,
RA Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M.,
RA Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S.,
RA Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E.,
RA Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K.,
RA Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E.,
RA Yoshikawa H., Danchin A.;
RT "The complete genome sequence of the Gram-positive bacterium Bacillus
RT subtilis.";
RL Nature 390:249-256(1997).
RN [5]
RP SEQUENCE REVISION TO 216 AND 332.
RX PubMed=19383706; DOI=10.1099/mic.0.027839-0;
RA Barbe V., Cruveiller S., Kunst F., Lenoble P., Meurice G., Sekowska A.,
RA Vallenet D., Wang T., Moszer I., Medigue C., Danchin A.;
RT "From a consortium sequence to a unified sequence: the Bacillus subtilis
RT 168 reference genome a decade later.";
RL Microbiology 155:1758-1775(2009).
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the methyl-accepting chemotaxis (MCP) protein
CC family. {ECO:0000305}.
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DR EMBL; Z34005; CAA83970.1; -; Genomic_DNA.
DR EMBL; D30762; BAA06432.1; -; Genomic_DNA.
DR EMBL; D50453; BAA08978.1; -; Genomic_DNA.
DR EMBL; AL009126; CAB12138.2; -; Genomic_DNA.
DR PIR; I40496; I40496.
DR RefSeq; NP_388226.2; NC_000964.3.
DR RefSeq; WP_003246498.1; NZ_JNCM01000030.1.
DR AlphaFoldDB; P39209; -.
DR SMR; P39209; -.
DR IntAct; P39209; 2.
DR STRING; 224308.BSU03440; -.
DR jPOST; P39209; -.
DR PaxDb; 224308-BSU03440; -.
DR EnsemblBacteria; CAB12138; CAB12138; BSU_03440.
DR GeneID; 938316; -.
DR KEGG; bsu:BSU03440; -.
DR PATRIC; fig|224308.179.peg.361; -.
DR eggNOG; COG0840; Bacteria.
DR eggNOG; COG3290; Bacteria.
DR InParanoid; P39209; -.
DR OrthoDB; 9814363at2; -.
DR PhylomeDB; P39209; -.
DR BioCyc; BSUB:BSU03440-MONOMER; -.
DR Proteomes; UP000001570; Chromosome.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro.
DR GO; GO:0006935; P:chemotaxis; IEA:UniProtKB-KW.
DR GO; GO:0007165; P:signal transduction; IEA:UniProtKB-KW.
DR CDD; cd06225; HAMP; 1.
DR CDD; cd11386; MCP_signal; 1.
DR Gene3D; 6.10.340.10; -; 1.
DR Gene3D; 1.10.287.950; Methyl-accepting chemotaxis protein; 1.
DR InterPro; IPR004090; Chemotax_Me-accpt_rcpt.
DR InterPro; IPR003660; HAMP_dom.
DR InterPro; IPR004089; MCPsignal_dom.
DR InterPro; IPR033463; sCache_3.
DR InterPro; IPR029151; Sensor-like_sf.
DR PANTHER; PTHR32089; METHYL-ACCEPTING CHEMOTAXIS PROTEIN MCPB; 1.
DR PANTHER; PTHR32089:SF114; METHYL-ACCEPTING CHEMOTAXIS PROTEIN MCPB; 1.
DR Pfam; PF00672; HAMP; 1.
DR Pfam; PF00015; MCPsignal; 1.
DR Pfam; PF17202; sCache_3_3; 1.
DR PRINTS; PR00260; CHEMTRNSDUCR.
DR SMART; SM00304; HAMP; 1.
DR SMART; SM00283; MA; 1.
DR SUPFAM; SSF58104; Methyl-accepting chemotaxis protein (MCP) signaling domain; 1.
DR SUPFAM; SSF103190; Sensory domain-like; 1.
DR PROSITE; PS50111; CHEMOTAXIS_TRANSDUC_2; 1.
DR PROSITE; PS50885; HAMP; 1.
PE 3: Inferred from homology;
KW Cell membrane; Chemotaxis; Membrane; Methylation; Reference proteome;
KW Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..573
FT /note="Methyl-accepting chemotaxis protein TlpC"
FT /id="PRO_0000110561"
FT TOPO_DOM 1..13
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 14..34
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 35..188
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 189..207
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 208..573
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 209..261
FT /note="HAMP"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00102"
FT DOMAIN 280..544
FT /note="Methyl-accepting transducer"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00284"
FT MOD_RES 276
FT /note="Glutamate methyl ester (Gln)"
FT /evidence="ECO:0000250"
FT MOD_RES 535
FT /note="Glutamate methyl ester (Glu)"
FT /evidence="ECO:0000250"
FT MOD_RES 542
FT /note="Glutamate methyl ester (Glu)"
FT /evidence="ECO:0000250"
FT CONFLICT 216
FT /note="N -> T (in Ref. 2; BAA06432 and 3; BAA08978)"
FT /evidence="ECO:0000305"
FT CONFLICT 332
FT /note="A -> P (in Ref. 2; BAA06432 and 3; BAA08978)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 573 AA; 61784 MW; 80E3A90EE35E5CDF CRC64;
MLIKRFKMKL GTKILCLVFV VILLFSASVG TVMLKEITES MKQMATEKAK GDLALSSTYI
DDVMSGDWQV KNNKLYKGQT QINGNEDIVD LLGEKTGDTI TIFQGDTRVA TNVMKNGERA
VGTQASSEVI AAVLKKGKRF YGQADVAGSS YQTAYMPLKD QNGNIIGMLY TGANQSILAS
LTQSLFTQFA IVLVIVIMVS VILVLVFTRK INKRLNALKS AFESAGNGDM TIEVSDKTGD
ELSELSVYYN KMRMKLNDTI QTVQQSALQL ASASQQLSAG AEETNQASEK ITEAVQQIAN
GAQDQITRIE NSESSLKQAS ADIRDISANT AAIADKGQLA QSKADIGQKE IANVQAQMDA
IHQSIQKSGE IIHQLDGRSK QIEQILSVIT QIADQTNLLA LNAAIEAARA GEQGKGFAVV
ADEVRKLAEE SQQSAGQISK LIIEIQKDMN RSARSVEHVK TEAAEGVTMI QRTRDAFKEI
AAATGEISAE ISDLSASVTN ISASAHQIND SFAANTADIK ESTKNTRQAA ALTEEQFAAM
EEITAASETL SQLAEELTGI ISQFKMINQA ENG
//
