ID OPSR_ANOCA Reviewed; 369 AA.
AC P41592;
DT 01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1995, sequence version 1.
DT 03-APR-2013, entry version 72.
DE RecName: Full=Red-sensitive opsin;
DE AltName: Full=Red cone photoreceptor pigment;
OS Anolis carolinensis (Green anole) (American chameleon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Lepidosauria; Squamata; Iguania; Iguanidae; Polychrotinae; Anolis.
OX NCBI_TaxID=28377;
RN [1]
RP NUCLEOTIDE SEQUENCE.
RX PubMed=8500618; DOI=10.1016/0014-5793(93)81350-9;
RA Kawamura S., Yokoyama S.;
RT "Molecular characterization of the red visual pigment gene of the
RT American chameleon (Anolis carolinensis).";
RL FEBS Lett. 323:247-251(1993).
CC -!- FUNCTION: Visual pigments are the light-absorbing molecules that
CC mediate vision. They consist of an apoprotein, opsin, covalently
CC linked to cis-retinal. This opsin uses a vitamin A2 chromophore.
CC -!- BIOPHYSICOCHEMICAL PROPERTIES:
CC Absorption:
CC Abs(max)=625 nm;
CC -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
CC -!- PTM: Phosphorylated on some or all of the serine and threonine
CC residues present in the C-terminal region (By similarity).
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC Opsin subfamily.
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DR EMBL; U08131; AAA17706.1; -; Unassigned_DNA.
DR PIR; S33250; S33250.
DR ProteinModelPortal; P41592; -.
DR Ensembl; ENSACAT00000012669; ENSACAP00000012416; ENSACAG00000012605.
DR eggNOG; NOG240324; -.
DR GeneTree; ENSGT00700000104057; -.
DR HOGENOM; HOG000253932; -.
DR HOVERGEN; HBG107442; -.
DR OMA; FCWGPYT; -.
DR OrthoDB; EOG40K806; -.
DR GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
DR GO; GO:0001750; C:photoreceptor outer segment; IEA:Compara.
DR GO; GO:0004930; F:G-protein coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0009881; F:photoreceptor activity; IEA:UniProtKB-KW.
DR GO; GO:0007602; P:phototransduction; IEA:UniProtKB-KW.
DR GO; GO:0018298; P:protein-chromophore linkage; IEA:UniProtKB-KW.
DR GO; GO:0007601; P:visual perception; IEA:UniProtKB-KW.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR001760; Opsin.
DR InterPro; IPR000378; Opsin_red/grn.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00238; OPSIN.
DR PRINTS; PR00575; OPSINREDGRN.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
DR PROSITE; PS00238; OPSIN; 1.
PE 1: Evidence at protein level;
KW Chromophore; Complete proteome; Disulfide bond;
KW G-protein coupled receptor; Glycoprotein; Membrane; Phosphoprotein;
KW Photoreceptor protein; Receptor; Reference proteome; Retinal protein;
KW Sensory transduction; Transducer; Transmembrane; Transmembrane helix;
KW Vision.
FT CHAIN 1 369 Red-sensitive opsin.
FT /FTId=PRO_0000197791.
FT TOPO_DOM 1 55 Extracellular.
FT TRANSMEM 56 80 Helical; Name=1; (Potential).
FT TOPO_DOM 81 92 Cytoplasmic.
FT TRANSMEM 93 117 Helical; Name=2; (Potential).
FT TOPO_DOM 118 132 Extracellular.
FT TRANSMEM 133 152 Helical; Name=3; (Potential).
FT TOPO_DOM 153 171 Cytoplasmic.
FT TRANSMEM 172 195 Helical; Name=4; (Potential).
FT TOPO_DOM 196 221 Extracellular.
FT TRANSMEM 222 249 Helical; Name=5; (Potential).
FT TOPO_DOM 250 271 Cytoplasmic.
FT TRANSMEM 272 295 Helical; Name=6; (Potential).
FT TOPO_DOM 296 303 Extracellular.
FT TRANSMEM 304 328 Helical; Name=7; (Potential).
FT TOPO_DOM 329 369 Cytoplasmic.
FT MOD_RES 315 315 N6-(retinylidene)lysine (By similarity).
FT CARBOHYD 37 37 N-linked (GlcNAc...) (Potential).
FT DISULFID 129 206 By similarity.
SQ SEQUENCE 369 AA; 40844 MW; D51E194661622B5E CRC64;
MAGTVTEAWD VAVFAARRRN DEDDTTRDSL FTYTNSNNTR GPFEGPNYHI APRWVYNITS
VWMIFVVIAS IFTNGLVLVA TAKFKKLRHP LNWILVNLAI ADLGETVIAS TISVINQISG
YFILGHPMCV LEGYTVSTCG ISALWSLAVI SWERWVVVCK PFGNVKFDAK LAVAGIVFSW
VWSAVWTAPP VFGWSRYWPH GLKTSCGPDV FSGSDDPGVL SYMIVLMITC CFIPLAVILL
CYLQVWLAIR AVAAQQKESE STQKAEKEVS RMVVVMIIAY CFCWGPYTVF ACFAAANPGY
AFHPLAAALP AYFAKSATIY NPIIYVFMNR QFRNCIMQLF GKKVDDGSEL SSTSRTEVSS
VSNSSVSPA
//
