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Database: UniProt
Entry: P41592
LinkDB: P41592
Original site: P41592 
ID   OPSR_ANOCA              Reviewed;         369 AA.
AC   P41592;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1995, sequence version 1.
DT   29-OCT-2014, entry version 82.
DE   RecName: Full=Red-sensitive opsin;
DE   AltName: Full=Red cone photoreceptor pigment;
OS   Anolis carolinensis (Green anole) (American chameleon).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata;
OC   Toxicofera; Iguania; Iguanidae; Polychrotinae; Anolis.
OX   NCBI_TaxID=28377;
RN   [1]
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=8500618; DOI=10.1016/0014-5793(93)81350-9;
RA   Kawamura S., Yokoyama S.;
RT   "Molecular characterization of the red visual pigment gene of the
RT   American chameleon (Anolis carolinensis).";
RL   FEBS Lett. 323:247-251(1993).
CC   -!- FUNCTION: Visual pigments are the light-absorbing molecules that
CC       mediate vision. They consist of an apoprotein, opsin, covalently
CC       linked to cis-retinal. This opsin uses a vitamin A2 chromophore.
CC   -!- BIOPHYSICOCHEMICAL PROPERTIES:
CC       Absorption:
CC         Abs(max)=625 nm;
CC   -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
CC   -!- PTM: Phosphorylated on some or all of the serine and threonine
CC       residues present in the C-terminal region. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC       Opsin subfamily. {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR   EMBL; U08131; AAA17706.1; -; Unassigned_DNA.
DR   PIR; S33250; S33250.
DR   RefSeq; XP_008102123.1; XM_008103916.1.
DR   ProteinModelPortal; P41592; -.
DR   STRING; 28377.ENSACAP00000012416; -.
DR   Ensembl; ENSACAT00000012669; ENSACAP00000012416; ENSACAG00000012605.
DR   GeneID; 100564371; -.
DR   eggNOG; NOG240324; -.
DR   GeneTree; ENSGT00760000118977; -.
DR   HOGENOM; HOG000253932; -.
DR   HOVERGEN; HBG107442; -.
DR   InParanoid; P41592; -.
DR   OMA; FCWGPYT; -.
DR   OrthoDB; EOG72NRQJ; -.
DR   TreeFam; TF324998; -.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0001750; C:photoreceptor outer segment; IEA:Ensembl.
DR   GO; GO:0004930; F:G-protein coupled receptor activity; IEA:UniProtKB-KW.
DR   GO; GO:0009881; F:photoreceptor activity; IEA:UniProtKB-KW.
DR   GO; GO:0007602; P:phototransduction; IEA:UniProtKB-KW.
DR   GO; GO:0018298; P:protein-chromophore linkage; IEA:UniProtKB-KW.
DR   GO; GO:0007601; P:visual perception; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.1070.10; -; 1.
DR   InterPro; IPR000276; GPCR_Rhodpsn.
DR   InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR   InterPro; IPR001760; Opsin.
DR   InterPro; IPR000378; Opsin_red/grn.
DR   InterPro; IPR027430; Retinal_BS.
DR   Pfam; PF00001; 7tm_1; 1.
DR   PRINTS; PR00237; GPCRRHODOPSN.
DR   PRINTS; PR00238; OPSIN.
DR   PRINTS; PR00575; OPSINREDGRN.
DR   PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
DR   PROSITE; PS00238; OPSIN; 1.
PE   1: Evidence at protein level;
KW   Chromophore; Complete proteome; Disulfide bond;
KW   G-protein coupled receptor; Glycoprotein; Membrane; Phosphoprotein;
KW   Photoreceptor protein; Receptor; Reference proteome; Retinal protein;
KW   Sensory transduction; Transducer; Transmembrane; Transmembrane helix;
KW   Vision.
FT   CHAIN         1    369       Red-sensitive opsin.
FT                                /FTId=PRO_0000197791.
FT   TOPO_DOM      1     55       Extracellular.
FT   TRANSMEM     56     80       Helical; Name=1. {ECO:0000255}.
FT   TOPO_DOM     81     92       Cytoplasmic.
FT   TRANSMEM     93    117       Helical; Name=2. {ECO:0000255}.
FT   TOPO_DOM    118    132       Extracellular.
FT   TRANSMEM    133    152       Helical; Name=3. {ECO:0000255}.
FT   TOPO_DOM    153    171       Cytoplasmic.
FT   TRANSMEM    172    195       Helical; Name=4. {ECO:0000255}.
FT   TOPO_DOM    196    221       Extracellular.
FT   TRANSMEM    222    249       Helical; Name=5. {ECO:0000255}.
FT   TOPO_DOM    250    271       Cytoplasmic.
FT   TRANSMEM    272    295       Helical; Name=6. {ECO:0000255}.
FT   TOPO_DOM    296    303       Extracellular.
FT   TRANSMEM    304    328       Helical; Name=7. {ECO:0000255}.
FT   TOPO_DOM    329    369       Cytoplasmic.
FT   MOD_RES     315    315       N6-(retinylidene)lysine. {ECO:0000250}.
FT   CARBOHYD     37     37       N-linked (GlcNAc...). {ECO:0000255}.
FT   DISULFID    129    206       {ECO:0000255|PROSITE-ProRule:PRU00521}.
SQ   SEQUENCE   369 AA;  40844 MW;  D51E194661622B5E CRC64;
     MAGTVTEAWD VAVFAARRRN DEDDTTRDSL FTYTNSNNTR GPFEGPNYHI APRWVYNITS
     VWMIFVVIAS IFTNGLVLVA TAKFKKLRHP LNWILVNLAI ADLGETVIAS TISVINQISG
     YFILGHPMCV LEGYTVSTCG ISALWSLAVI SWERWVVVCK PFGNVKFDAK LAVAGIVFSW
     VWSAVWTAPP VFGWSRYWPH GLKTSCGPDV FSGSDDPGVL SYMIVLMITC CFIPLAVILL
     CYLQVWLAIR AVAAQQKESE STQKAEKEVS RMVVVMIIAY CFCWGPYTVF ACFAAANPGY
     AFHPLAAALP AYFAKSATIY NPIIYVFMNR QFRNCIMQLF GKKVDDGSEL SSTSRTEVSS
     VSNSSVSPA
//
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