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Database: UniProt
Entry: P41996
LinkDB: P41996
Original site: P41996 
ID   CPG2_CAEEL              Reviewed;         524 AA.
AC   P41996; Q1A3T5;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   15-AUG-2003, sequence version 3.
DT   16-APR-2014, entry version 95.
DE   RecName: Full=Chondroitin proteoglycan-2;
DE   AltName: Full=Cytokinesis protein B0280.5;
DE   Flags: Precursor;
GN   Name=cpg-2; ORFNames=B0280.5;
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], IDENTIFICATION BY MASS SPECTROMETRY,
RP   GLYCOSYLATION AT SER-103; SER-119; SER-208 AND SER-212, FUNCTION, AND
RP   DISRUPTION PHENOTYPE.
RX   PubMed=16785326; DOI=10.1083/jcb.200603003;
RA   Olson S.K., Bishop J.R., Yates J.R., Oegema K., Esko J.D.;
RT   "Identification of novel chondroitin proteoglycans in Caenorhabditis
RT   elegans: embryonic cell division depends on CPG-1 and CPG-2.";
RL   J. Cell Biol. 173:985-994(2006).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for
RT   investigating biology.";
RL   Science 282:2012-2018(1998).
RN   [3]
RP   TISSUE SPECIFICITY, AND DEVELOPMENTAL STAGE.
RX   PubMed=11030340; DOI=10.1016/S1097-2765(00)00059-9;
RA   Reinke V., Smith H.E., Nance J., Wang J., Van Doren C., Begley R.,
RA   Jones S.J.M., Davis E.B., Scherer S., Ward S., Kim S.K.;
RT   "A global profile of germline gene expression in C. elegans.";
RL   Mol. Cell 6:605-616(2000).
RN   [4]
RP   FUNCTION.
RX   PubMed=11562350; DOI=10.1101/gad.915901;
RA   Lee M.-H., Schedl T.;
RT   "Identification of in vivo mRNA targets of GLD-1, a maxi-KH motif
RT   containing protein required for C. elegans germ cell development.";
RL   Genes Dev. 15:2408-2420(2001).
RN   [5]
RP   FUNCTION.
RX   PubMed=17042944; DOI=10.1186/1741-7007-4-35;
RA   Johnston W.L., Krizus A., Dennis J.W.;
RT   "The eggshell is required for meiotic fidelity, polar-body extrusion
RT   and polarization of the C. elegans embryo.";
RL   BMC Biol. 4:35-35(2006).
RN   [6]
RP   FUNCTION.
RX   PubMed=17913784; DOI=10.1242/dev.011361;
RA   Bembenek J.N., Richie C.T., Squirrell J.M., Campbell J.M.,
RA   Eliceiri K.W., Poteryaev D., Spang A., Golden A., White J.G.;
RT   "Cortical granule exocytosis in C. elegans is regulated by cell cycle
RT   components including separase.";
RL   Development 134:3837-3848(2007).
CC   -!- FUNCTION: Required for polar body extrusion during cytokinesis in
CC       embryo development. Affects cortical granule size. Has roles in
CC       meiotic chromosome segregation, osmotic barrier function and
CC       polarization in conjunction with cpg-2. Binds chitin.
CC   -!- TISSUE SPECIFICITY: Expressed in the germline.
CC   -!- DEVELOPMENTAL STAGE: Expressed throughout development but appears
CC       to be up-regulated in adults.
CC   -!- DISRUPTION PHENOTYPE: Worms lacking cpg-2 and cpg-1 exhibit
CC       defects in cytokinesis during embryo development more specifically
CC       meiotic chromosome segregation, polar-body extrusion, osmotic
CC       barrier function and polarization. Embryos lacking cpg-2 and cpg-1
CC       proteins have multiple nuclei lacking plasma membranes and may
CC       also have weak egg shells. Oocytes lacking cpg-2 and cpg-1 show
CC       cortical granules that are reduced in size.
CC   -!- SIMILARITY: Contains 6 chitin-binding type-2 domains.
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DR   EMBL; DQ340624; ABC65812.1; -; mRNA.
DR   EMBL; FO080148; CCD61602.1; -; Genomic_DNA.
DR   PIR; T15299; T15299.
DR   RefSeq; NP_498551.3; NM_066150.10.
DR   UniGene; Cel.17405; -.
DR   ProteinModelPortal; P41996; -.
DR   SMR; P41996; 27-80, 138-192, 251-295, 309-358, 415-451.
DR   BioGrid; 41203; 1.
DR   MINT; MINT-1061878; -.
DR   STRING; 6239.B0280.5; -.
DR   CAZy; CBM14; Carbohydrate-Binding Module Family 14.
DR   PaxDb; P41996; -.
DR   EnsemblMetazoa; B0280.5.1; B0280.5.1; B0280.5.
DR   EnsemblMetazoa; B0280.5.2; B0280.5.2; B0280.5.
DR   GeneID; 175991; -.
DR   KEGG; cel:CELE_B0280.5; -.
DR   UCSC; B0280.5; c. elegans.
DR   CTD; 175991; -.
DR   WormBase; B0280.5; CE31868; WBGene00015102; cpg-2.
DR   eggNOG; NOG241358; -.
DR   HOGENOM; HOG000017714; -.
DR   InParanoid; P41996; -.
DR   OMA; FDCSTDG; -.
DR   PhylomeDB; P41996; -.
DR   NextBio; 890638; -.
DR   GO; GO:0005576; C:extracellular region; IEA:InterPro.
DR   GO; GO:0008061; F:chitin binding; IDA:UniProtKB.
DR   GO; GO:0006030; P:chitin metabolic process; IEA:InterPro.
DR   GO; GO:0030703; P:eggshell formation; NAS:UniProtKB.
DR   GO; GO:0009790; P:embryo development; IMP:UniProtKB.
DR   GO; GO:0000281; P:mitotic cytokinesis; IMP:UniProtKB.
DR   GO; GO:0032465; P:regulation of cytokinesis; IGI:WormBase.
DR   Gene3D; 2.170.140.10; -; 5.
DR   InterPro; IPR002557; Chitin-bd_dom.
DR   Pfam; PF01607; CBM_14; 6.
DR   SMART; SM00494; ChtBD2; 6.
DR   SUPFAM; SSF57625; SSF57625; 6.
DR   PROSITE; PS50940; CHIT_BIND_II; 6.
PE   1: Evidence at protein level;
KW   Cell cycle; Cell division; Chitin-binding; Complete proteome;
KW   Developmental protein; Disulfide bond; Glycoprotein; Proteoglycan;
KW   Reference proteome; Repeat; Signal.
FT   SIGNAL        1     18       Potential.
FT   CHAIN        19    524       Chondroitin proteoglycan-2.
FT                                /FTId=PRO_0000023617.
FT   DOMAIN       21     78       Chitin-binding type-2 1.
FT   DOMAIN      135    192       Chitin-binding type-2 2.
FT   DOMAIN      244    301       Chitin-binding type-2 3.
FT   DOMAIN      306    361       Chitin-binding type-2 4.
FT   DOMAIN      400    456       Chitin-binding type-2 5.
FT   DOMAIN      469    524       Chitin-binding type-2 6.
FT   COMPBIAS     75    258       Gly-rich.
FT   CARBOHYD    103    103       O-linked (Xyl...) (chondroitin sulfate).
FT   CARBOHYD    119    119       O-linked (Xyl...) (chondroitin sulfate).
FT   CARBOHYD    208    208       O-linked (Xyl...) (chondroitin sulfate).
FT   CARBOHYD    212    212       O-linked (Xyl...) (chondroitin sulfate).
FT   CARBOHYD    355    355       N-linked (GlcNAc...) (Potential).
FT   CARBOHYD    497    497       N-linked (GlcNAc...) (Potential).
FT   DISULFID     54     67       By similarity.
FT   DISULFID    168    181       By similarity.
FT   DISULFID    277    290       By similarity.
FT   DISULFID    337    350       By similarity.
FT   DISULFID    432    445       By similarity.
FT   DISULFID    500    514       By similarity.
SQ   SEQUENCE   524 AA;  53652 MW;  FFCB9A750385FB34 CRC64;
     MKTVAALTLL AFATAANGQF LQDCTNALDG LYALGECEPQ FLTCSGGIAR IMDCPADLIY
     NEPLLICDWR HNVIGCEGSG ESSGETSGEG SGESSGEASG EGSGEASGEG SGEASGEGSG
     EASGEGSGSG EETVENVCEN LEDGAYSSGG CTTYYFFCTT NTARFLSCPT PLFYDADSQK
     CIWKSLVEEC KEDLTITDGS GETSGEGSGE ASGEASGEGS GEASGESSGQ GSGEASGEGS
     GELEPTCEGK ADGIHPNGVC STNFLTCSGG IARIMDCPAS LVFNPTILVC DWPRDVAECA
     GLPTPQPTCE EDGYFSFGQC SSSFTACTNG RAIVMFCPAG LKFSESTVRC DYESNVSECQ
     ETSGEESGEA SGEQSGEGSG EASGEASGES SGEGSGVEEQ NQCVGLDNGL HAIGCSPRVL
     SCQNGHVDIF ECPSSLVFND QSLICDYPQT SLKCLIEDTI LIDETPIAAF DCSTDGLFSD
     GLCSATYHQC TAGQLINFTC AASNAVFSAA NTECVDSSTL LQCH
//
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