ID LEP_BACLI Reviewed; 186 AA.
AC P42668;
DT 01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1995, sequence version 1.
DT 06-MAR-2013, entry version 82.
DE RecName: Full=Signal peptidase I;
DE Short=SPase I;
DE EC=3.4.21.89;
DE AltName: Full=Leader peptidase I;
GN Name=lepB; Synonyms=sip;
OS Bacillus licheniformis.
OC Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus.
OX NCBI_TaxID=1402;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ATCC 9789 / DSM 8785 / NBRC 12195 / NCTC 6346 / IMET 11025;
RA Hoang V., Birger A., Hofemeister J.;
RL Submitted (NOV-1993) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY: Cleavage of hydrophobic, N-terminal signal or
CC leader sequences from secreted and periplasmic proteins.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Single-pass type II membrane
CC protein (Potential).
CC -!- SIMILARITY: Belongs to the peptidase S26 family.
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DR EMBL; X75604; CAA53272.1; -; Genomic_DNA.
DR ProteinModelPortal; P42668; -.
DR MEROPS; S26.004; -.
DR GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008236; F:serine-type peptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR Gene3D; 2.10.109.10; -; 2.
DR InterPro; IPR000223; Pept_S26A_signal_pept_1.
DR InterPro; IPR019758; Pept_S26A_signal_pept_1_CS.
DR InterPro; IPR019757; Pept_S26A_signal_pept_1_Lys-AS.
DR InterPro; IPR019756; Pept_S26A_signal_pept_1_Ser-AS.
DR InterPro; IPR019759; Peptidase_S24_S26.
DR InterPro; IPR015927; Peptidase_S24_S26A/B/C.
DR InterPro; IPR011056; Peptidase_S24_S26A/B/C_b-rbn.
DR PANTHER; PTHR12383; PTHR12383; 1.
DR Pfam; PF00717; Peptidase_S24; 1.
DR PRINTS; PR00727; LEADERPTASE.
DR SUPFAM; SSF51306; Pept_S24_S26_C; 1.
DR TIGRFAMs; TIGR02227; sigpep_I_bact; 1.
DR PROSITE; PS00501; SPASE_I_1; 1.
DR PROSITE; PS00760; SPASE_I_2; 1.
DR PROSITE; PS00761; SPASE_I_3; 1.
PE 3: Inferred from homology;
KW Cell membrane; Hydrolase; Membrane; Protease; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1 186 Signal peptidase I.
FT /FTId=PRO_0000109496.
FT TOPO_DOM 1 19 Cytoplasmic (Potential).
FT TRANSMEM 20 40 Helical; (Potential).
FT TOPO_DOM 41 186 Extracellular (Potential).
FT ACT_SITE 44 44 By similarity.
FT ACT_SITE 86 86 By similarity.
SQ SEQUENCE 186 AA; 21145 MW; F8F82EB84F8BF5B8 CRC64;
MTEEKSTNKK NSLFEWVKAI IIAVVLALLI RAFLFEPYLV EGTSMDPTLH DGERLFVYKT
VRYVGEFKRG DIVIIDGDEK NVHYVKRLIG LPGDTVQMKD DTLYINGKKV SEPYLSENRK
EAEAVGVKLT GDFGPVKVPE GKYFVMGDNR QRSMDSRNGL GLIDKKRVAG TSQFVFFPFN
EIRKTD
//
