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Database: UniProt
Entry: P42675
LinkDB: P42675
Original site: P42675 
ID   NEUL_RABIT              Reviewed;         704 AA.
AC   P42675;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1995, sequence version 1.
DT   13-NOV-2013, entry version 88.
DE   RecName: Full=Neurolysin, mitochondrial;
DE            EC=3.4.24.16;
DE   AltName: Full=Microsomal endopeptidase;
DE            Short=MEP;
DE   AltName: Full=Mitochondrial oligopeptidase M;
DE   AltName: Full=Neurotensin endopeptidase;
DE   Flags: Precursor;
GN   Name=NLN;
OS   Oryctolagus cuniculus (Rabbit).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae;
OC   Oryctolagus.
OX   NCBI_TaxID=9986;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND PARTIAL PROTEIN SEQUENCE.
RC   TISSUE=Liver;
RX   PubMed=8509389;
RA   Kawabata S., Nakagawa K., Muta T., Iwanaga S., Davie E.W.;
RT   "Rabbit liver microsomal endopeptidase with substrate specificity for
RT   processing proproteins is structurally related to rat testes
RT   metalloendopeptidase 24.15.";
RL   J. Biol. Chem. 268:12498-12503(1993).
CC   -!- FUNCTION: Hydrolyzes oligopeptides such as neurotensin, bradykinin
CC       and dynorphin A (By similarity).
CC   -!- CATALYTIC ACTIVITY: Preferential cleavage in neurotensin: 10-
CC       Pro-|-Tyr-11.
CC   -!- COFACTOR: Binds 1 zinc ion per subunit (By similarity).
CC   -!- SUBCELLULAR LOCATION: Mitochondrion (By similarity). Cytoplasm (By
CC       similarity).
CC   -!- SIMILARITY: Belongs to the peptidase M3 family.
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DR   EMBL; D13310; BAA02570.1; -; mRNA.
DR   PIR; A45985; A45985.
DR   ProteinModelPortal; P42675; -.
DR   SMR; P42675; 37-701.
DR   STRING; 9986.ENSOCUP00000008123; -.
DR   MEROPS; M03.002; -.
DR   PRIDE; P42675; -.
DR   eggNOG; COG0339; -.
DR   HOGENOM; HOG000245985; -.
DR   HOVERGEN; HBG000238; -.
DR   GO; GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0004222; F:metalloendopeptidase activity; IEA:InterPro.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.1370.10; -; 2.
DR   Gene3D; 1.20.1050.40; -; 1.
DR   Gene3D; 3.40.390.10; -; 1.
DR   InterPro; IPR024079; MetalloPept_cat_dom.
DR   InterPro; IPR024077; Neurolysin/TOP_dom2.
DR   InterPro; IPR024080; Neurolysin/TOP_N.
DR   InterPro; IPR001567; Pept_M3A_M3B.
DR   Pfam; PF01432; Peptidase_M3; 1.
DR   PROSITE; PS00142; ZINC_PROTEASE; 1.
PE   1: Evidence at protein level;
KW   Acetylation; Complete proteome; Cytoplasm; Direct protein sequencing;
KW   Hydrolase; Metal-binding; Metalloprotease; Mitochondrion; Protease;
KW   Reference proteome; Transit peptide; Zinc.
FT   TRANSIT       1     37       Mitochondrion (By similarity).
FT   CHAIN        38    704       Neurolysin, mitochondrial.
FT                                /FTId=PRO_0000028577.
FT   ACT_SITE    498    498       By similarity.
FT   METAL       497    497       Zinc; catalytic (By similarity).
FT   METAL       501    501       Zinc; catalytic (By similarity).
FT   METAL       504    504       Zinc; catalytic (By similarity).
FT   MOD_RES     664    664       N6-acetyllysine (By similarity).
SQ   SEQUENCE   704 AA;  80689 MW;  A1B7E4DE38E8088C CRC64;
     MIARCFSAVR GLHRVGGSRI LFKMTLGREV MSPLQAVSSY TAAGRNVLRW DLSPEQIKTR
     TEELIAQTKQ VYDSVGMLDI KDVTYENCLQ ALADVEVKYI VERTMLDFPQ HVSTDREVRA
     ASTEADKRLS RFDIEMSMRE DIFQRIVHLQ ETCDLEKIKP EARRYLEKSV KMGRRNGLHL
     PEEVQNEIKS MKKRMSELCI DFNKNLNEDD TFLVFSKAEL GALPDDFIDS LEKMDDDKYK
     ITLKYPHYFP VMKKCCIPET RRRMEMAFNT RCKEENTVIL QQLLPLRAQV AKLLGYSTHA
     DFVLEMNTAK STSRVTAFLD DLSQKLKPLG EAEREFILSL KKKECEEKGF EYDGKINAWD
     LHYYMTQTEE LKYSIDQEFI KEYFPIEVVT EGLLNIYQEL LGLSFEQVAD AHVWNPSVTL
     YTVKDKATGE VLGQFYLDLY PREGKYNHAA CFGLQPGCLL PDGSRMLSVA ALVVNFSQPV
     AGRPSLLRHD EVRTYFHEFG HVMHQICAQT DFARFSGTNV ETDFVEVPSQ MLENWVWDID
     SLRRLSKHYK DGNPIADDLL EKLVASRLVN TGLLTLRQIV LSKVDQSLHT NSSLDAASEY
     ARYCTDILGV AATPGTNMPA TFGHLAGGYD GQYYGYLWSE VFSMDMFYSC FKKEGIMNPE
     VGMKYRNLIL RPGGSLDGMD MLQNFLQREP NQKAFLMSRG LQAP
//
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