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Database: UniProt
Entry: P43081
LinkDB: P43081
Original site: P43081 
ID   GUC1A_MOUSE             Reviewed;         202 AA.
AC   P43081; Q8R0H3;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   03-OCT-2012, sequence version 3.
DT   03-SEP-2014, entry version 115.
DE   RecName: Full=Guanylyl cyclase-activating protein 1;
DE            Short=GCAP 1;
DE   AltName: Full=Guanylate cyclase activator 1A;
GN   Name=Guca1a; Synonyms=Gcap, Gcap1, Guca1;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;
OC   Muroidea; Muridae; Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=BALB/c; TISSUE=Retina;
RX   PubMed=7983048;
RA   Subbaraya I., Ruiz C.C., Helekar B.S., Zhao X., Gorczyca W.A.,
RA   Pettenati M.J., Rao P.N., Palczewski K., Baehr W.;
RT   "Molecular characterization of human and mouse photoreceptor guanylate
RT   cyclase-activating protein (GCAP) and chromosomal localization of the
RT   human gene.";
RL   J. Biol. Chem. 269:31080-31089(1994).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C57BL/6J;
RX   PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA   Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S.,
RA   She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W.,
RA   Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T.,
RA   Zhou S., Teague B., Potamousis K., Churas C., Place M., Herschleb J.,
RA   Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z.,
RA   Lindblad-Toh K., Eichler E.E., Ponting C.P.;
RT   "Lineage-specific biology revealed by a finished genome assembly of
RT   the mouse.";
RL   PLoS Biol. 7:E1000112-E1000112(2009).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
RL   Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Eye;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Stimulates guanylyl cyclase 1 (GC1) when free calcium
CC       ions concentration is low and inhibits GC1 when free calcium ions
CC       concentration is elevated. This Ca(2+)-sensitive regulation of GC
CC       is a key event in recovery of the dark state of rod photoreceptors
CC       following light exposure.
CC   -!- SUBCELLULAR LOCATION: Membrane; Lipid-anchor.
CC   -!- TISSUE SPECIFICITY: Retina; rod and cone outer segments.
CC   -!- MISCELLANEOUS: Binds three calcium ions (By similarity).
CC   -!- SIMILARITY: Contains 4 EF-hand domains.
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DR   EMBL; L36860; AAA60716.1; -; mRNA.
DR   EMBL; AC112683; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CH466559; EDL23558.1; -; Genomic_DNA.
DR   EMBL; CH466559; EDL23559.1; -; Genomic_DNA.
DR   EMBL; CH466559; EDL23560.1; -; Genomic_DNA.
DR   EMBL; BC026834; AAH26834.1; -; mRNA.
DR   EMBL; BC031810; AAH31810.1; -; mRNA.
DR   CCDS; CCDS28848.1; -.
DR   PIR; B55331; B55331.
DR   RefSeq; NP_032215.2; NM_008189.2.
DR   UniGene; Mm.16224; -.
DR   ProteinModelPortal; P43081; -.
DR   SMR; P43081; 5-185.
DR   STRING; 10090.ENSMUSP00000060027; -.
DR   PRIDE; P43081; -.
DR   Ensembl; ENSMUST00000059348; ENSMUSP00000060027; ENSMUSG00000023982.
DR   GeneID; 14913; -.
DR   KEGG; mmu:14913; -.
DR   UCSC; uc008cvc.1; mouse.
DR   CTD; 2978; -.
DR   MGI; MGI:102770; Guca1a.
DR   eggNOG; COG5126; -.
DR   GeneTree; ENSGT00630000089657; -.
DR   HOGENOM; HOG000233019; -.
DR   HOVERGEN; HBG108179; -.
DR   InParanoid; P43081; -.
DR   KO; K08328; -.
DR   OMA; IEGVQKD; -.
DR   OrthoDB; EOG7BP83V; -.
DR   TreeFam; TF333971; -.
DR   Reactome; REACT_188266; Inactivation, recovery and regulation of the phototransduction cascade.
DR   NextBio; 287205; -.
DR   PRO; PR:P43081; -.
DR   CleanEx; MM_GUCA1A; -.
DR   Genevestigator; P43081; -.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0001917; C:photoreceptor inner segment; IEA:Ensembl.
DR   GO; GO:0001750; C:photoreceptor outer segment; IEA:Ensembl.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0008048; F:calcium sensitive guanylate cyclase activator activity; IDA:MGI.
DR   GO; GO:0030249; F:guanylate cyclase regulator activity; IGI:MGI.
DR   GO; GO:0007602; P:phototransduction; IMP:MGI.
DR   GO; GO:0030828; P:positive regulation of cGMP biosynthetic process; IEA:Ensembl.
DR   GO; GO:0031282; P:regulation of guanylate cyclase activity; IGI:MGI.
DR   GO; GO:0007601; P:visual perception; IMP:MGI.
DR   Gene3D; 1.10.238.10; -; 1.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR028846; Recoverin.
DR   PANTHER; PTHR23055; PTHR23055; 1.
DR   Pfam; PF13499; EF-hand_7; 1.
DR   SMART; SM00054; EFh; 3.
DR   PROSITE; PS00018; EF_HAND_1; 3.
DR   PROSITE; PS50222; EF_HAND_2; 4.
PE   2: Evidence at transcript level;
KW   Calcium; Complete proteome; Lipoprotein; Membrane; Metal-binding;
KW   Myristate; Reference proteome; Repeat; Sensory transduction; Vision.
FT   INIT_MET      1      1       Removed (Potential).
FT   CHAIN         2    202       Guanylyl cyclase-activating protein 1.
FT                                /FTId=PRO_0000073804.
FT   DOMAIN       14     49       EF-hand 1.
FT   DOMAIN       51     86       EF-hand 2.
FT   DOMAIN       87    122       EF-hand 3.
FT   DOMAIN      131    166       EF-hand 4.
FT   CA_BIND      64     75       1 (Potential).
FT   CA_BIND     100    111       2 (Potential).
FT   CA_BIND     144    155       3 (Potential).
FT   MOD_RES       3      3       Deamidated asparagine (Potential).
FT   LIPID         2      2       N-myristoyl glycine (Potential).
FT   CONFLICT      4      4       I -> V (in Ref. 1; AAA60716).
FT   CONFLICT     29     29       C -> V (in Ref. 1; AAA60716).
FT   CONFLICT    194    194       G -> S (in Ref. 1; AAA60716).
SQ   SEQUENCE   202 AA;  22986 MW;  EC76CBF7C518C76B CRC64;
     MGNIMEGKSV EELSSTECHQ WYKKFMTECP SGQLTLYEFR QFFGLKNLSP SASQYVEQMF
     ETFDFNKDGY IDFMEYVAAL SLVLKGKVEQ KLRWYFKLYD VDGNGCIDRD ELLTIIRAIR
     TINPWSDSSM SAEEFTDTVF AKIDINGDGE LSLEEFMEGV QKDQMLLDTL TRSLDLTGIV
     RRLQNGEHEE AGTGDLAAEA AG
//
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