GenomeNet

Database: UniProt
Entry: P43081
LinkDB: P43081
Original site: P43081 
ID   GUC1A_MOUSE             Reviewed;         202 AA.
AC   P43081; Q8R0H3;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   03-OCT-2012, sequence version 3.
DT   11-MAY-2016, entry version 130.
DE   RecName: Full=Guanylyl cyclase-activating protein 1;
DE            Short=GCAP 1;
DE   AltName: Full=Guanylate cyclase activator 1A;
GN   Name=Guca1a; Synonyms=Gcap, Gcap1, Guca1;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;
OC   Muroidea; Muridae; Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=BALB/cJ; TISSUE=Retina;
RX   PubMed=7983048;
RA   Subbaraya I., Ruiz C.C., Helekar B.S., Zhao X., Gorczyca W.A.,
RA   Pettenati M.J., Rao P.N., Palczewski K., Baehr W.;
RT   "Molecular characterization of human and mouse photoreceptor guanylate
RT   cyclase-activating protein (GCAP) and chromosomal localization of the
RT   human gene.";
RL   J. Biol. Chem. 269:31080-31089(1994).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C57BL/6J;
RX   PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA   Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S.,
RA   She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W.,
RA   Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T.,
RA   Zhou S., Teague B., Potamousis K., Churas C., Place M., Herschleb J.,
RA   Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z.,
RA   Lindblad-Toh K., Eichler E.E., Ponting C.P.;
RT   "Lineage-specific biology revealed by a finished genome assembly of
RT   the mouse.";
RL   PLoS Biol. 7:E1000112-E1000112(2009).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
RL   Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Eye;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Stimulates retinal guanylyl cyclase when free calcium
CC       ions concentration is low and inhibits guanylyl cyclase when free
CC       calcium ions concentration is elevated. This Ca(2+)-sensitive
CC       regulation of retinal guanylyl cyclase is a key event in recovery
CC       of the dark state of rod photoreceptors following light exposure.
CC       {ECO:0000250|UniProtKB:P46065}.
CC   -!- SUBCELLULAR LOCATION: Membrane; Lipid-anchor.
CC   -!- TISSUE SPECIFICITY: Retina; rod and cone outer segments.
CC   -!- DOMAIN: Binds three calcium ions (via EF-hands 2, 3 and 4) when
CC       calcium levels are high. Binds Mg(2+) when calcium levels are low.
CC       {ECO:0000250|UniProtKB:P46065}.
CC   -!- SIMILARITY: Contains 4 EF-hand domains. {ECO:0000255|PROSITE-
CC       ProRule:PRU00448}.
DR   EMBL; L36860; AAA60716.1; -; mRNA.
DR   EMBL; AC112683; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CH466559; EDL23558.1; -; Genomic_DNA.
DR   EMBL; CH466559; EDL23559.1; -; Genomic_DNA.
DR   EMBL; CH466559; EDL23560.1; -; Genomic_DNA.
DR   EMBL; BC026834; AAH26834.1; -; mRNA.
DR   EMBL; BC031810; AAH31810.1; -; mRNA.
DR   CCDS; CCDS28848.1; -.
DR   PIR; B55331; B55331.
DR   RefSeq; NP_032215.2; NM_008189.3.
DR   RefSeq; XP_011244598.1; XM_011246296.1.
DR   UniGene; Mm.16224; -.
DR   ProteinModelPortal; P43081; -.
DR   SMR; P43081; 5-185.
DR   STRING; 10090.ENSMUSP00000060027; -.
DR   PaxDb; P43081; -.
DR   PRIDE; P43081; -.
DR   Ensembl; ENSMUST00000059348; ENSMUSP00000060027; ENSMUSG00000023982.
DR   GeneID; 14913; -.
DR   KEGG; mmu:14913; -.
DR   UCSC; uc008cvc.1; mouse.
DR   CTD; 2978; -.
DR   MGI; MGI:102770; Guca1a.
DR   eggNOG; KOG0044; Eukaryota.
DR   eggNOG; COG5126; LUCA.
DR   GeneTree; ENSGT00760000118820; -.
DR   HOGENOM; HOG000233019; -.
DR   HOVERGEN; HBG108179; -.
DR   InParanoid; P43081; -.
DR   KO; K08328; -.
DR   OMA; INPCSDS; -.
DR   OrthoDB; EOG7BP83V; -.
DR   TreeFam; TF333971; -.
DR   Reactome; R-MMU-2514859; Inactivation, recovery and regulation of the phototransduction cascade.
DR   NextBio; 287205; -.
DR   PRO; PR:P43081; -.
DR   Proteomes; UP000000589; Chromosome 17.
DR   CleanEx; MM_GUCA1A; -.
DR   Genevisible; P43081; MM.
DR   GO; GO:0001917; C:photoreceptor inner segment; IEA:Ensembl.
DR   GO; GO:0001750; C:photoreceptor outer segment; IDA:MGI.
DR   GO; GO:0005886; C:plasma membrane; ISO:MGI.
DR   GO; GO:0005509; F:calcium ion binding; ISS:UniProtKB.
DR   GO; GO:0008048; F:calcium sensitive guanylate cyclase activator activity; IDA:MGI.
DR   GO; GO:0030249; F:guanylate cyclase regulator activity; IGI:MGI.
DR   GO; GO:0071277; P:cellular response to calcium ion; ISS:UniProtKB.
DR   GO; GO:0007602; P:phototransduction; IMP:MGI.
DR   GO; GO:0031282; P:regulation of guanylate cyclase activity; IGI:MGI.
DR   GO; GO:0007601; P:visual perception; IMP:MGI.
DR   Gene3D; 1.10.238.10; -; 1.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR   InterPro; IPR002048; EF_hand_dom.
DR   Pfam; PF00036; EF-hand_1; 1.
DR   Pfam; PF13499; EF-hand_7; 1.
DR   SMART; SM00054; EFh; 3.
DR   SUPFAM; SSF47473; SSF47473; 1.
DR   PROSITE; PS00018; EF_HAND_1; 3.
DR   PROSITE; PS50222; EF_HAND_2; 4.
PE   2: Evidence at transcript level;
KW   Calcium; Complete proteome; Lipoprotein; Membrane; Metal-binding;
KW   Myristate; Reference proteome; Repeat; Sensory transduction; Vision.
FT   INIT_MET      1      1       Removed. {ECO:0000255}.
FT   CHAIN         2    202       Guanylyl cyclase-activating protein 1.
FT                                /FTId=PRO_0000073804.
FT   DOMAIN       14     49       EF-hand 1. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00448}.
FT   DOMAIN       51     86       EF-hand 2. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00448}.
FT   DOMAIN       87    122       EF-hand 3. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00448}.
FT   DOMAIN      131    166       EF-hand 4. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00448}.
FT   CA_BIND      64     75       1. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00448}.
FT   CA_BIND     100    111       2. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00448}.
FT   CA_BIND     144    155       3. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00448}.
FT   MOD_RES       3      3       Deamidated asparagine. {ECO:0000255}.
FT   LIPID         2      2       N-myristoyl glycine.
FT                                {ECO:0000250|UniProtKB:P46065}.
FT   CONFLICT      4      4       I -> V (in Ref. 1; AAA60716).
FT                                {ECO:0000305}.
FT   CONFLICT     29     29       C -> V (in Ref. 1; AAA60716).
FT                                {ECO:0000305}.
FT   CONFLICT    194    194       G -> S (in Ref. 1; AAA60716).
FT                                {ECO:0000305}.
SQ   SEQUENCE   202 AA;  22986 MW;  EC76CBF7C518C76B CRC64;
     MGNIMEGKSV EELSSTECHQ WYKKFMTECP SGQLTLYEFR QFFGLKNLSP SASQYVEQMF
     ETFDFNKDGY IDFMEYVAAL SLVLKGKVEQ KLRWYFKLYD VDGNGCIDRD ELLTIIRAIR
     TINPWSDSSM SAEEFTDTVF AKIDINGDGE LSLEEFMEGV QKDQMLLDTL TRSLDLTGIV
     RRLQNGEHEE AGTGDLAAEA AG
//
DBGET integrated database retrieval system