ID GUC1A_MOUSE Reviewed; 202 AA.
AC P43081; Q8R0H3;
DT 01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT 03-OCT-2012, sequence version 3.
DT 01-MAY-2013, entry version 102.
DE RecName: Full=Guanylyl cyclase-activating protein 1;
DE Short=GCAP 1;
DE AltName: Full=Guanylate cyclase activator 1A;
GN Name=Guca1a; Synonyms=Gcap, Gcap1, Guca1;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;
OC Muroidea; Muridae; Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=BALB/c; TISSUE=Retina;
RX PubMed=7983048;
RA Subbaraya I., Ruiz C.C., Helekar B.S., Zhao X., Gorczyca W.A.,
RA Pettenati M.J., Rao P.N., Palczewski K., Baehr W.;
RT "Molecular characterization of human and mouse photoreceptor guanylate
RT cyclase-activating protein (GCAP) and chromosomal localization of the
RT human gene.";
RL J. Biol. Chem. 269:31080-31089(1994).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S.,
RA She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W.,
RA Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T.,
RA Zhou S., Teague B., Potamousis K., Churas C., Place M., Herschleb J.,
RA Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z.,
RA Lindblad-Toh K., Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of
RT the mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Eye;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Stimulates guanylyl cyclase 1 (GC1) when free calcium
CC ions concentration is low and inhibits GC1 when free calcium ions
CC concentration is elevated. This Ca(2+)-sensitive regulation of GC
CC is a key event in recovery of the dark state of rod photoreceptors
CC following light exposure.
CC -!- SUBCELLULAR LOCATION: Membrane; Lipid-anchor.
CC -!- TISSUE SPECIFICITY: Retina; rod and cone outer segments.
CC -!- MISCELLANEOUS: Binds three calcium ions (By similarity).
CC -!- SIMILARITY: Contains 4 EF-hand domains.
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DR EMBL; L36860; AAA60716.1; -; mRNA.
DR EMBL; AC112683; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH466559; EDL23558.1; -; Genomic_DNA.
DR EMBL; CH466559; EDL23559.1; -; Genomic_DNA.
DR EMBL; CH466559; EDL23560.1; -; Genomic_DNA.
DR EMBL; BC026834; AAH26834.1; -; mRNA.
DR EMBL; BC031810; AAH31810.1; -; mRNA.
DR IPI; IPI00277915; -.
DR IPI; IPI00396803; -.
DR PIR; B55331; B55331.
DR RefSeq; NP_032215.2; NM_008189.2.
DR UniGene; Mm.16224; -.
DR ProteinModelPortal; P43081; -.
DR SMR; P43081; 5-185.
DR STRING; 10090.ENSMUSP00000060027; -.
DR PRIDE; P43081; -.
DR Ensembl; ENSMUST00000059348; ENSMUSP00000060027; ENSMUSG00000023982.
DR GeneID; 14913; -.
DR KEGG; mmu:14913; -.
DR CTD; 2978; -.
DR MGI; MGI:102770; Guca1a.
DR eggNOG; COG5126; -.
DR GeneTree; ENSGT00630000089657; -.
DR HOGENOM; HOG000233019; -.
DR HOVERGEN; HBG108179; -.
DR InParanoid; P43081; -.
DR KO; K08328; -.
DR OMA; EFTDTVF; -.
DR OrthoDB; EOG45X7X4; -.
DR NextBio; 287205; -.
DR CleanEx; MM_GUCA1A; -.
DR Genevestigator; P43081; -.
DR GermOnline; ENSMUSG00000023982; Mus musculus.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0008048; F:calcium sensitive guanylate cyclase activator activity; IDA:MGI.
DR GO; GO:0007602; P:phototransduction; IMP:MGI.
DR GO; GO:0007601; P:visual perception; IMP:MGI.
DR Gene3D; 1.10.238.10; -; 1.
DR InterPro; IPR011992; EF-hand-like_dom.
DR InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR InterPro; IPR002048; EF_hand_dom.
DR InterPro; IPR001125; Recoverin.
DR Pfam; PF13499; EF_hand_5; 1.
DR PRINTS; PR00450; RECOVERIN.
DR SMART; SM00054; EFh; 3.
DR PROSITE; PS00018; EF_HAND_1; 3.
DR PROSITE; PS50222; EF_HAND_2; 4.
PE 2: Evidence at transcript level;
KW Calcium; Complete proteome; Lipoprotein; Membrane; Metal-binding;
KW Myristate; Reference proteome; Repeat; Sensory transduction; Vision.
FT INIT_MET 1 1 Removed (Potential).
FT CHAIN 2 202 Guanylyl cyclase-activating protein 1.
FT /FTId=PRO_0000073804.
FT DOMAIN 14 49 EF-hand 1.
FT DOMAIN 51 86 EF-hand 2.
FT DOMAIN 87 122 EF-hand 3.
FT DOMAIN 131 166 EF-hand 4.
FT CA_BIND 64 75 1 (Potential).
FT CA_BIND 100 111 2 (Potential).
FT CA_BIND 144 155 3 (Potential).
FT MOD_RES 3 3 Deamidated asparagine (Potential).
FT LIPID 2 2 N-myristoyl glycine (Potential).
FT CONFLICT 4 4 I -> V (in Ref. 1; AAA60716).
FT CONFLICT 29 29 C -> V (in Ref. 1; AAA60716).
FT CONFLICT 194 194 G -> S (in Ref. 1; AAA60716).
SQ SEQUENCE 202 AA; 22986 MW; EC76CBF7C518C76B CRC64;
MGNIMEGKSV EELSSTECHQ WYKKFMTECP SGQLTLYEFR QFFGLKNLSP SASQYVEQMF
ETFDFNKDGY IDFMEYVAAL SLVLKGKVEQ KLRWYFKLYD VDGNGCIDRD ELLTIIRAIR
TINPWSDSSM SAEEFTDTVF AKIDINGDGE LSLEEFMEGV QKDQMLLDTL TRSLDLTGIV
RRLQNGEHEE AGTGDLAAEA AG
//
