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Entry: P43372
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ID   COX2_BRENA              Reviewed;         248 AA.
AC   P43372;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1995, sequence version 1.
DT   16-APR-2014, entry version 80.
DE   RecName: Full=Cytochrome c oxidase subunit 2;
DE            EC=1.9.3.1;
DE   AltName: Full=Cytochrome c oxidase polypeptide II;
GN   Name=COX2;
OS   Brettanomyces naardenensis (Yeast).
OG   Mitochondrion.
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina;
OC   Saccharomycetes; Saccharomycetales; mitosporic Saccharomycetales;
OC   Brettanomyces.
OX   NCBI_TaxID=13370;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=CBS 6042;
RX   PubMed=8387113; DOI=10.1007/BF00160482;
RA   Hoeben P., Weiller G., Clark-Walker G.D.;
RT   "Larger rearranged mitochondrial genomes in Dekkera/Brettanomyces
RT   yeasts are more closely related than smaller genomes with a conserved
RT   gene order.";
RL   J. Mol. Evol. 36:263-269(1993).
CC   -!- FUNCTION: Cytochrome c oxidase is the component of the respiratory
CC       chain that catalyzes the reduction of oxygen to water. Subunits 1-
CC       3 form the functional core of the enzyme complex. Subunit 2
CC       transfers the electrons from cytochrome c via its binuclear copper
CC       A center to the bimetallic center of the catalytic subunit 1.
CC   -!- CATALYTIC ACTIVITY: 4 ferrocytochrome c + O(2) + 4 H(+) = 4
CC       ferricytochrome c + 2 H(2)O.
CC   -!- COFACTOR: Copper A.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane; Multi-pass
CC       membrane protein.
CC   -!- SIMILARITY: Belongs to the cytochrome c oxidase subunit 2 family.
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DR   EMBL; X64821; CAA46033.1; -; Genomic_DNA.
DR   PIR; S33372; S33372.
DR   ProteinModelPortal; P43372; -.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0070469; C:respiratory chain; IEA:UniProtKB-KW.
DR   GO; GO:0005507; F:copper ion binding; IEA:InterPro.
DR   GO; GO:0004129; F:cytochrome-c oxidase activity; IEA:UniProtKB-EC.
DR   GO; GO:0022900; P:electron transport chain; IEA:InterPro.
DR   Gene3D; 1.10.287.90; -; 1.
DR   Gene3D; 2.60.40.420; -; 1.
DR   InterPro; IPR001505; Copper_CuA.
DR   InterPro; IPR008972; Cupredoxin.
DR   InterPro; IPR014222; Cyt_c_oxidase_su2.
DR   InterPro; IPR002429; Cyt_c_oxidase_su2_C.
DR   InterPro; IPR011759; Cyt_c_oxidase_su2_TM_dom.
DR   Pfam; PF00116; COX2; 1.
DR   Pfam; PF02790; COX2_TM; 1.
DR   SUPFAM; SSF49503; SSF49503; 1.
DR   SUPFAM; SSF81464; SSF81464; 1.
DR   TIGRFAMs; TIGR02866; CoxB; 1.
DR   PROSITE; PS00078; COX2; 1.
DR   PROSITE; PS50857; COX2_CUA; 1.
DR   PROSITE; PS50999; COX2_TM; 1.
PE   3: Inferred from homology;
KW   Copper; Electron transport; Membrane; Metal-binding; Mitochondrion;
KW   Mitochondrion inner membrane; Oxidoreductase; Respiratory chain;
KW   Transmembrane; Transmembrane helix; Transport.
FT   CHAIN         1    248       Cytochrome c oxidase subunit 2.
FT                                /FTId=PRO_0000183523.
FT   TOPO_DOM      1     39       Mitochondrial intermembrane (Potential).
FT   TRANSMEM     40     56       Helical; (Potential).
FT   TOPO_DOM     57     87       Mitochondrial matrix (Potential).
FT   TRANSMEM     88    104       Helical; (Potential).
FT   TOPO_DOM    105    248       Mitochondrial intermembrane (Potential).
FT   METAL       183    183       Copper A (Probable).
FT   METAL       218    218       Copper A (Probable).
FT   METAL       222    222       Copper A (Probable).
FT   METAL       226    226       Copper A (Probable).
SQ   SEQUENCE   248 AA;  28554 MW;  4FD2689F5AE192AE CRC64;
     MMKELLMNNM LNDVPTPWAM YFQDSATPNM EGIMELHNNV VFYLIIMLCF VTYMLYNIST
     VYNKSAVAYK YMNHGQFIEM VWTTFPAVML LIMAFPSFML LYICDEVMAP AMTIKAMGLQ
     WYWKYEYSDF MDEKGETIEF ESYIIPEDLL EDGQLRMLDV DASVVCPVDT HIRFIVTSAD
     VIHDFCMPSL GIKIDAAPGR LNQTSALIQR EGVYYGQCSE LCGVMHSAMP IKIEVVPTAD
     FLTWIDEQ
//
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