ID COX2_BRENA Reviewed; 248 AA.
AC P43372;
DT 01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1995, sequence version 1.
DT 01-MAY-2013, entry version 76.
DE RecName: Full=Cytochrome c oxidase subunit 2;
DE EC=1.9.3.1;
DE AltName: Full=Cytochrome c oxidase polypeptide II;
GN Name=COX2;
OS Brettanomyces naardenensis (Yeast).
OG Mitochondrion.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina;
OC Saccharomycetes; Saccharomycetales; mitosporic Saccharomycetales;
OC Brettanomyces.
OX NCBI_TaxID=13370;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=CBS 6042;
RX PubMed=8387113; DOI=10.1007/BF00160482;
RA Hoeben P., Weiller G., Clark-Walker G.D.;
RT "Larger rearranged mitochondrial genomes in Dekkera/Brettanomyces
RT yeasts are more closely related than smaller genomes with a conserved
RT gene order.";
RL J. Mol. Evol. 36:263-269(1993).
CC -!- FUNCTION: Cytochrome c oxidase is the component of the respiratory
CC chain that catalyzes the reduction of oxygen to water. Subunits 1-
CC 3 form the functional core of the enzyme complex. Subunit 2
CC transfers the electrons from cytochrome c via its binuclear copper
CC A center to the bimetallic center of the catalytic subunit 1.
CC -!- CATALYTIC ACTIVITY: 4 ferrocytochrome c + O(2) + 4 H(+) = 4
CC ferricytochrome c + 2 H(2)O.
CC -!- COFACTOR: Copper A.
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane; Multi-pass
CC membrane protein.
CC -!- SIMILARITY: Belongs to the cytochrome c oxidase subunit 2 family.
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DR EMBL; X64821; CAA46033.1; -; Genomic_DNA.
DR PIR; S33372; S33372.
DR ProteinModelPortal; P43372; -.
DR GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
DR GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0070469; C:respiratory chain; IEA:UniProtKB-KW.
DR GO; GO:0005507; F:copper ion binding; IEA:InterPro.
DR GO; GO:0004129; F:cytochrome-c oxidase activity; IEA:EC.
DR GO; GO:0022900; P:electron transport chain; IEA:UniProtKB-KW.
DR Gene3D; 1.10.287.90; -; 1.
DR Gene3D; 2.60.40.420; -; 1.
DR InterPro; IPR001505; Copper_CuA.
DR InterPro; IPR008972; Cupredoxin.
DR InterPro; IPR014222; Cyt_c_oxidase_su2.
DR InterPro; IPR002429; Cyt_c_oxidase_su2_C.
DR InterPro; IPR011759; Cyt_c_oxidase_su2_TM_dom.
DR Pfam; PF00116; COX2; 1.
DR Pfam; PF02790; COX2_TM; 1.
DR SUPFAM; SSF49503; Cupredoxin; 1.
DR SUPFAM; SSF81464; Cyt_c_oxidase_II-like_TM; 1.
DR TIGRFAMs; TIGR02866; CoxB; 1.
DR PROSITE; PS00078; COX2; 1.
DR PROSITE; PS50857; COX2_CUA; 1.
DR PROSITE; PS50999; COX2_TM; 1.
PE 3: Inferred from homology;
KW Copper; Electron transport; Membrane; Metal-binding; Mitochondrion;
KW Mitochondrion inner membrane; Oxidoreductase; Respiratory chain;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1 248 Cytochrome c oxidase subunit 2.
FT /FTId=PRO_0000183523.
FT TOPO_DOM 1 39 Mitochondrial intermembrane (Potential).
FT TRANSMEM 40 56 Helical; (Potential).
FT TOPO_DOM 57 87 Mitochondrial matrix (Potential).
FT TRANSMEM 88 104 Helical; (Potential).
FT TOPO_DOM 105 248 Mitochondrial intermembrane (Potential).
FT METAL 183 183 Copper A (Probable).
FT METAL 218 218 Copper A (Probable).
FT METAL 222 222 Copper A (Probable).
FT METAL 226 226 Copper A (Probable).
SQ SEQUENCE 248 AA; 28554 MW; 4FD2689F5AE192AE CRC64;
MMKELLMNNM LNDVPTPWAM YFQDSATPNM EGIMELHNNV VFYLIIMLCF VTYMLYNIST
VYNKSAVAYK YMNHGQFIEM VWTTFPAVML LIMAFPSFML LYICDEVMAP AMTIKAMGLQ
WYWKYEYSDF MDEKGETIEF ESYIIPEDLL EDGQLRMLDV DASVVCPVDT HIRFIVTSAD
VIHDFCMPSL GIKIDAAPGR LNQTSALIQR EGVYYGQCSE LCGVMHSAMP IKIEVVPTAD
FLTWIDEQ
//
