ID TRUC_HAEIN Reviewed; 239 AA.
AC P44197;
DT 01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1997, sequence version 2.
DT 01-MAY-2013, entry version 75.
DE RecName: Full=tRNA pseudouridine synthase C;
DE EC=5.4.99.26;
DE AltName: Full=tRNA pseudouridine(65) synthase;
DE AltName: Full=tRNA pseudouridylate synthase C;
DE AltName: Full=tRNA-uridine isomerase C;
GN Name=truC; OrderedLocusNames=HI_1435;
OS Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales;
OC Pasteurellaceae; Haemophilus.
OX NCBI_TaxID=71421;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 51907 / DSM 11121 / KW20 / Rd;
RX PubMed=7542800; DOI=10.1126/science.7542800;
RA Fleischmann R.D., Adams M.D., White O., Clayton R.A., Kirkness E.F.,
RA Kerlavage A.R., Bult C.J., Tomb J.-F., Dougherty B.A., Merrick J.M.,
RA McKenney K., Sutton G.G., FitzHugh W., Fields C.A., Gocayne J.D.,
RA Scott J.D., Shirley R., Liu L.-I., Glodek A., Kelley J.M.,
RA Weidman J.F., Phillips C.A., Spriggs T., Hedblom E., Cotton M.D.,
RA Utterback T.R., Hanna M.C., Nguyen D.T., Saudek D.M., Brandon R.C.,
RA Fine L.D., Fritchman J.L., Fuhrmann J.L., Geoghagen N.S.M.,
RA Gnehm C.L., McDonald L.A., Small K.V., Fraser C.M., Smith H.O.,
RA Venter J.C.;
RT "Whole-genome random sequencing and assembly of Haemophilus influenzae
RT Rd.";
RL Science 269:496-512(1995).
CC -!- FUNCTION: Responsible for synthesis of pseudouridine from uracil-
CC 65 in transfer RNAs (By similarity).
CC -!- CATALYTIC ACTIVITY: tRNA uridine(65) = tRNA pseudouridine(65).
CC -!- SIMILARITY: Belongs to the pseudouridine synthase RluA family.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAC23084.2; Type=Frameshift; Positions=160;
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DR EMBL; L42023; AAC23084.2; ALT_FRAME; Genomic_DNA.
DR PIR; I64029; I64029.
DR RefSeq; NP_439586.2; NC_000907.1.
DR STRING; 71421.HI1435; -.
DR EnsemblBacteria; AAC23084; AAC23084; HI_1435.
DR GeneID; 950339; -.
DR KEGG; hin:HI1435; -.
DR PATRIC; 20191571; VBIHaeInf48452_1495.
DR eggNOG; COG0564; -.
DR KO; K06175; -.
DR OMA; FHPIMGD; -.
DR GO; GO:0009982; F:pseudouridine synthase activity; IEA:InterPro.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0001522; P:pseudouridine synthesis; IEA:InterPro.
DR GO; GO:0008033; P:tRNA processing; IEA:UniProtKB-KW.
DR InterPro; IPR020103; PsdUridine_synth_cat_dom.
DR InterPro; IPR006224; PsdUridine_synth_RluC/D_CS.
DR InterPro; IPR006145; PsdUridine_synth_RsuA/RluD.
DR Pfam; PF00849; PseudoU_synth_2; 1.
DR SUPFAM; SSF55120; PsdUridine_synth_cat_dom; 1.
DR PROSITE; PS01129; PSI_RLU; 1.
PE 3: Inferred from homology;
KW Complete proteome; Isomerase; Reference proteome; tRNA processing.
FT CHAIN 1 239 tRNA pseudouridine synthase C.
FT /FTId=PRO_0000162715.
FT ACT_SITE 54 54 By similarity.
SQ SEQUENCE 239 AA; 27777 MW; 6D9409FD8E379CE4 CRC64;
MLEILYQDGF LVAVNKPAGM LVHRSWLDPH ETQFVMQTLR DQIGQHVFPI HRLDRPTSGV
LLFALSSEIA NLMCEQFEQK YVQKSYLAVV RGYLQGKERI DYPLKIQLDK IADKFSQEDK
EPQEAITDYE GLKIVEMPYP AGRYQTARYS LVKLIPHTGR KHXLRXHMKH VFHPIXGDTQ
YGDLHQNRAL MSHLGCSRLF LHSDSLSFIH PITKEQITIT AGLDEQWQQL MNQFGWENV
//
