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Database: UniProt
Entry: P45607
LinkDB: P45607
Original site: P45607 
ID   PHOB_SHIFL              Reviewed;         229 AA.
AC   P45607;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   10-JAN-2003, sequence version 2.
DT   14-MAY-2014, entry version 109.
DE   RecName: Full=Phosphate regulon transcriptional regulatory protein PhoB;
GN   Name=phoB; OrderedLocusNames=SF0336, S0344;
OS   Shigella flexneri.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacteriales;
OC   Enterobacteriaceae; Shigella.
OX   NCBI_TaxID=623;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=M25-8 / Serotype 2a;
RX   PubMed=7746146; DOI=10.1111/j.1365-2958.1995.tb02239.x;
RA   Scholten M., Janssen R., Bogaarts C., van Strien J., Tommassen J.;
RT   "The pho regulon of Shigella flexneri.";
RL   Mol. Microbiol. 15:247-254(1995).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=301 / Serotype 2a;
RX   PubMed=12384590; DOI=10.1093/nar/gkf566;
RA   Jin Q., Yuan Z., Xu J., Wang Y., Shen Y., Lu W., Wang J., Liu H.,
RA   Yang J., Yang F., Zhang X., Zhang J., Yang G., Wu H., Qu D., Dong J.,
RA   Sun L., Xue Y., Zhao A., Gao Y., Zhu J., Kan B., Ding K., Chen S.,
RA   Cheng H., Yao Z., He B., Chen R., Ma D., Qiang B., Wen Y., Hou Y.,
RA   Yu J.;
RT   "Genome sequence of Shigella flexneri 2a: insights into pathogenicity
RT   through comparison with genomes of Escherichia coli K12 and O157.";
RL   Nucleic Acids Res. 30:4432-4441(2002).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700930 / 2457T / Serotype 2a;
RX   PubMed=12704152; DOI=10.1128/IAI.71.5.2775-2786.2003;
RA   Wei J., Goldberg M.B., Burland V., Venkatesan M.M., Deng W.,
RA   Fournier G., Mayhew G.F., Plunkett G. III, Rose D.J., Darling A.,
RA   Mau B., Perna N.T., Payne S.M., Runyen-Janecky L.J., Zhou S.,
RA   Schwartz D.C., Blattner F.R.;
RT   "Complete genome sequence and comparative genomics of Shigella
RT   flexneri serotype 2a strain 2457T.";
RL   Infect. Immun. 71:2775-2786(2003).
CC   -!- FUNCTION: This protein is a positive regulator for the phosphate
CC       regulon. Transcription of this operon is positively regulated by
CC       PhoB and PhoR when phosphate is limited.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm.
CC   -!- PTM: Phosphorylated by PhoR (By similarity).
CC   -!- SIMILARITY: Contains 1 response regulatory domain.
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DR   EMBL; X81000; CAA56927.1; -; Genomic_DNA.
DR   EMBL; AE005674; AAN41994.1; -; Genomic_DNA.
DR   EMBL; AE014073; AAP15872.1; -; Genomic_DNA.
DR   PIR; S61298; S61298.
DR   RefSeq; NP_706287.1; NC_004337.2.
DR   RefSeq; NP_836066.1; NC_004741.1.
DR   ProteinModelPortal; P45607; -.
DR   SMR; P45607; 1-229.
DR   STRING; 198214.SF0336; -.
DR   PaxDb; P45607; -.
DR   EnsemblBacteria; AAN41994; AAN41994; SF0336.
DR   EnsemblBacteria; AAP15872; AAP15872; S0344.
DR   GeneID; 1027627; -.
DR   GeneID; 1076777; -.
DR   KEGG; sfl:SF0336; -.
DR   KEGG; sfx:S0344; -.
DR   PATRIC; 18701680; VBIShiFle31049_0373.
DR   eggNOG; COG0745; -.
DR   HOGENOM; HOG000034819; -.
DR   KO; K07657; -.
DR   OMA; DWMIPGG; -.
DR   OrthoDB; EOG6G4VQG; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000156; F:phosphorelay response regulator activity; IEA:InterPro.
DR   GO; GO:0006817; P:phosphate ion transport; IEA:UniProtKB-KW.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:UniProtKB-KW.
DR   GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR011006; CheY-like_superfamily.
DR   InterPro; IPR001867; Sig_transdc_resp-reg_C.
DR   InterPro; IPR011879; Sig_transdc_resp-reg_PhoB.
DR   InterPro; IPR001789; Sig_transdc_resp-reg_receiver.
DR   InterPro; IPR011991; WHTH_DNA-bd_dom.
DR   Pfam; PF00072; Response_reg; 1.
DR   Pfam; PF00486; Trans_reg_C; 1.
DR   SMART; SM00448; REC; 1.
DR   SMART; SM00862; Trans_reg_C; 1.
DR   SUPFAM; SSF52172; SSF52172; 1.
DR   TIGRFAMs; TIGR02154; PhoB; 1.
DR   PROSITE; PS50110; RESPONSE_REGULATORY; 1.
PE   3: Inferred from homology;
KW   Activator; Complete proteome; Cytoplasm; DNA-binding;
KW   Phosphate transport; Phosphoprotein; Transcription;
KW   Transcription regulation; Transport; Two-component regulatory system.
FT   CHAIN         1    229       Phosphate regulon transcriptional
FT                                regulatory protein PhoB.
FT                                /FTId=PRO_0000081193.
FT   DOMAIN        1    120       Response regulatory.
FT   MOD_RES      53     53       4-aspartylphosphate (By similarity).
FT   CONFLICT    140    140       N -> D (in Ref. 1; CAA56927).
FT   CONFLICT    172    172       R -> L (in Ref. 1; CAA56927).
SQ   SEQUENCE   229 AA;  26431 MW;  E3E63880059D8CA9 CRC64;
     MARRILVVED EAPIREMVCF VLEQNGFQPV EAEDYDSAVN QLNEPWPDLI LLDWMLPGGS
     GIQFIKHLKR ESMTRDIPVV MLTARGEEED RVRGLETGAD DYITKPFSPK ELVARIKAVM
     RRISPMAVEE VIKMQGLSLN PTSHRVMAGE EPLEMGPTEF KLLHFFMTHP ERVYSREQLL
     NHVWGTNVYV EDRTVDVHIR RLRKALEPGG HDRMVQTVRG TGYRFSTRF
//
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