ID PHOB_SHIFL Reviewed; 229 AA.
AC P45607;
DT 01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT 10-JAN-2003, sequence version 2.
DT 01-MAY-2013, entry version 104.
DE RecName: Full=Phosphate regulon transcriptional regulatory protein PhoB;
GN Name=phoB; OrderedLocusNames=SF0336, S0344;
OS Shigella flexneri.
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacteriales;
OC Enterobacteriaceae; Shigella.
OX NCBI_TaxID=623;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=M25-8 / Serotype 2a;
RX PubMed=7746146; DOI=10.1111/j.1365-2958.1995.tb02239.x;
RA Scholten M., Janssen R., Bogaarts C., van Strien J., Tommassen J.;
RT "The pho regulon of Shigella flexneri.";
RL Mol. Microbiol. 15:247-254(1995).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=301 / Serotype 2a;
RX PubMed=12384590; DOI=10.1093/nar/gkf566;
RA Jin Q., Yuan Z., Xu J., Wang Y., Shen Y., Lu W., Wang J., Liu H.,
RA Yang J., Yang F., Zhang X., Zhang J., Yang G., Wu H., Qu D., Dong J.,
RA Sun L., Xue Y., Zhao A., Gao Y., Zhu J., Kan B., Ding K., Chen S.,
RA Cheng H., Yao Z., He B., Chen R., Ma D., Qiang B., Wen Y., Hou Y.,
RA Yu J.;
RT "Genome sequence of Shigella flexneri 2a: insights into pathogenicity
RT through comparison with genomes of Escherichia coli K12 and O157.";
RL Nucleic Acids Res. 30:4432-4441(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 700930 / 2457T / Serotype 2a;
RX PubMed=12704152; DOI=10.1128/IAI.71.5.2775-2786.2003;
RA Wei J., Goldberg M.B., Burland V., Venkatesan M.M., Deng W.,
RA Fournier G., Mayhew G.F., Plunkett G. III, Rose D.J., Darling A.,
RA Mau B., Perna N.T., Payne S.M., Runyen-Janecky L.J., Zhou S.,
RA Schwartz D.C., Blattner F.R.;
RT "Complete genome sequence and comparative genomics of Shigella
RT flexneri serotype 2a strain 2457T.";
RL Infect. Immun. 71:2775-2786(2003).
CC -!- FUNCTION: This protein is a positive regulator for the phosphate
CC regulon. Transcription of this operon is positively regulated by
CC PhoB and PhoR when phosphate is limited.
CC -!- SUBCELLULAR LOCATION: Cytoplasm.
CC -!- PTM: Phosphorylated by PhoR (By similarity).
CC -!- SIMILARITY: Contains 1 response regulatory domain.
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DR EMBL; X81000; CAA56927.1; -; Genomic_DNA.
DR EMBL; AE005674; AAN41994.1; -; Genomic_DNA.
DR EMBL; AE014073; AAP15872.1; -; Genomic_DNA.
DR PIR; S61298; S61298.
DR RefSeq; NP_706287.1; NC_004337.2.
DR RefSeq; NP_836066.1; NC_004741.1.
DR ProteinModelPortal; P45607; -.
DR SMR; P45607; 1-229.
DR STRING; 198214.SF0336; -.
DR PaxDb; P45607; -.
DR EnsemblBacteria; AAN41994; AAN41994; SF0336.
DR EnsemblBacteria; AAP15872; AAP15872; S0344.
DR GeneID; 1027627; -.
DR GeneID; 1076777; -.
DR KEGG; sfl:SF0336; -.
DR KEGG; sfx:S0344; -.
DR PATRIC; 18701680; VBIShiFle31049_0373.
DR eggNOG; COG0745; -.
DR HOGENOM; HOG000034819; -.
DR KO; K07657; -.
DR OMA; QVLEMGP; -.
DR ProtClustDB; PRK10161; -.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0000156; F:phosphorelay response regulator activity; IEA:InterPro.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:GOC.
DR GO; GO:0006817; P:phosphate ion transport; IEA:UniProtKB-KW.
DR GO; GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.
DR GO; GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
DR Gene3D; 1.10.10.10; -; 1.
DR InterPro; IPR011006; CheY-like_superfamily.
DR InterPro; IPR001867; Sig_transdc_resp-reg_C.
DR InterPro; IPR011879; Sig_transdc_resp-reg_PhoB.
DR InterPro; IPR001789; Sig_transdc_resp-reg_receiver.
DR InterPro; IPR011991; WHTH_DNA-bd_dom.
DR Pfam; PF00072; Response_reg; 1.
DR Pfam; PF00486; Trans_reg_C; 1.
DR SMART; SM00448; REC; 1.
DR SMART; SM00862; Trans_reg_C; 1.
DR SUPFAM; SSF52172; CheY_like; 1.
DR TIGRFAMs; TIGR02154; PhoB; 1.
DR PROSITE; PS50110; RESPONSE_REGULATORY; 1.
PE 3: Inferred from homology;
KW Activator; Complete proteome; Cytoplasm; DNA-binding;
KW Phosphate transport; Phosphoprotein; Transcription;
KW Transcription regulation; Transport; Two-component regulatory system.
FT CHAIN 1 229 Phosphate regulon transcriptional
FT regulatory protein PhoB.
FT /FTId=PRO_0000081193.
FT DOMAIN 1 120 Response regulatory.
FT MOD_RES 53 53 4-aspartylphosphate (By similarity).
FT CONFLICT 140 140 N -> D (in Ref. 1; CAA56927).
FT CONFLICT 172 172 R -> L (in Ref. 1; CAA56927).
SQ SEQUENCE 229 AA; 26431 MW; E3E63880059D8CA9 CRC64;
MARRILVVED EAPIREMVCF VLEQNGFQPV EAEDYDSAVN QLNEPWPDLI LLDWMLPGGS
GIQFIKHLKR ESMTRDIPVV MLTARGEEED RVRGLETGAD DYITKPFSPK ELVARIKAVM
RRISPMAVEE VIKMQGLSLN PTSHRVMAGE EPLEMGPTEF KLLHFFMTHP ERVYSREQLL
NHVWGTNVYV EDRTVDVHIR RLRKALEPGG HDRMVQTVRG TGYRFSTRF
//
