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Database: UniProt
Entry: P48871
LinkDB: P48871
Original site: P48871 
ID   COX2_WICCA              Reviewed;         247 AA.
AC   P48871;
DT   01-FEB-1996, integrated into UniProtKB/Swiss-Prot.
DT   30-AUG-2002, sequence version 2.
DT   16-APR-2014, entry version 89.
DE   RecName: Full=Cytochrome c oxidase subunit 2;
DE            EC=1.9.3.1;
DE   AltName: Full=Cytochrome c oxidase polypeptide II;
DE   Flags: Precursor;
GN   Name=COX2;
OS   Wickerhamomyces canadensis (Yeast) (Pichia canadensis).
OG   Mitochondrion.
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina;
OC   Saccharomycetes; Saccharomycetales; Phaffomycetaceae; Wickerhamomyces.
OX   NCBI_TaxID=1156965;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=21;
RX   PubMed=8536312; DOI=10.1007/BF00311880;
RA   Sekito T., Okamoto K., Kitano H., Yoshida K.;
RT   "The complete mitochondrial DNA sequence of Hansenula wingei reveals
RT   new characteristics of yeast mitochondria.";
RL   Curr. Genet. 28:39-53(1995).
CC   -!- FUNCTION: Cytochrome c oxidase is the component of the respiratory
CC       chain that catalyzes the reduction of oxygen to water. Subunits 1-
CC       3 form the functional core of the enzyme complex. Subunit 2
CC       transfers the electrons from cytochrome c via its binuclear copper
CC       A center to the bimetallic center of the catalytic subunit 1.
CC   -!- CATALYTIC ACTIVITY: 4 ferrocytochrome c + O(2) + 4 H(+) = 4
CC       ferricytochrome c + 2 H(2)O.
CC   -!- COFACTOR: Copper A.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane; Multi-pass
CC       membrane protein.
CC   -!- PTM: The signal sequence of COX2 is processed by IMP1 (By
CC       similarity).
CC   -!- SIMILARITY: Belongs to the cytochrome c oxidase subunit 2 family.
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DR   EMBL; D31785; BAA06577.2; -; Genomic_DNA.
DR   PIR; S58754; S58754.
DR   RefSeq; NP_038222.1; NC_001762.1.
DR   ProteinModelPortal; P48871; -.
DR   GeneID; 800566; -.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0070469; C:respiratory chain; IEA:UniProtKB-KW.
DR   GO; GO:0005507; F:copper ion binding; IEA:InterPro.
DR   GO; GO:0004129; F:cytochrome-c oxidase activity; IEA:UniProtKB-EC.
DR   GO; GO:0022900; P:electron transport chain; IEA:InterPro.
DR   Gene3D; 1.10.287.90; -; 1.
DR   Gene3D; 2.60.40.420; -; 1.
DR   InterPro; IPR001505; Copper_CuA.
DR   InterPro; IPR008972; Cupredoxin.
DR   InterPro; IPR014222; Cyt_c_oxidase_su2.
DR   InterPro; IPR002429; Cyt_c_oxidase_su2_C.
DR   InterPro; IPR011759; Cyt_c_oxidase_su2_TM_dom.
DR   Pfam; PF00116; COX2; 1.
DR   Pfam; PF02790; COX2_TM; 1.
DR   SUPFAM; SSF49503; SSF49503; 1.
DR   SUPFAM; SSF81464; SSF81464; 1.
DR   TIGRFAMs; TIGR02866; CoxB; 1.
DR   PROSITE; PS00078; COX2; 1.
DR   PROSITE; PS50857; COX2_CUA; 1.
DR   PROSITE; PS50999; COX2_TM; 1.
PE   3: Inferred from homology;
KW   Copper; Electron transport; Membrane; Metal-binding; Mitochondrion;
KW   Mitochondrion inner membrane; Oxidoreductase; Respiratory chain;
KW   Signal; Transmembrane; Transmembrane helix; Transport.
FT   SIGNAL        1     11       By similarity.
FT   CHAIN        12    247       Cytochrome c oxidase subunit 2.
FT                                /FTId=PRO_0000006038.
FT   TOPO_DOM     12     38       Mitochondrial intermembrane (Potential).
FT   TRANSMEM     39     59       Helical; (Potential).
FT   TOPO_DOM     60     78       Mitochondrial matrix (Potential).
FT   TRANSMEM     79    101       Helical; (Potential).
FT   TOPO_DOM    102    247       Mitochondrial intermembrane (Potential).
FT   METAL       182    182       Copper A (Probable).
FT   METAL       217    217       Copper A (Probable).
FT   METAL       221    221       Copper A (Probable).
FT   METAL       225    225       Copper A (Probable).
SQ   SEQUENCE   247 AA;  27809 MW;  C41D811809897DDD CRC64;
     MLLIINNIIN NDVPTPWGVY FQDSATPNHE GIIELHDNIM FYLVLILCLV SWLLFSIVKD
     GSKNPLPHKY LVHGQTIEII WTILPALVLL VIAFPSFILL YLCDEVISPA MTIKAIGLQW
     YWKYEYSDFI NDSGETIEFE SYVIPEDLLE DGQLPLLDTD TSIVCPVNTH IRFIVSAADV
     IHDFAVPSLG IKIDACPGRL NQVSALIQRE GVYYGQCSEL CGVAHSAMPI KVEAVSLKEF
     LTWLNEQ
//
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