ID COX2_WICCA Reviewed; 247 AA.
AC P48871;
DT 01-FEB-1996, integrated into UniProtKB/Swiss-Prot.
DT 30-AUG-2002, sequence version 2.
DT 01-MAY-2013, entry version 85.
DE RecName: Full=Cytochrome c oxidase subunit 2;
DE EC=1.9.3.1;
DE AltName: Full=Cytochrome c oxidase polypeptide II;
DE Flags: Precursor;
GN Name=COX2;
OS Wickerhamomyces canadensis (Yeast) (Pichia canadensis).
OG Mitochondrion.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina;
OC Saccharomycetes; Saccharomycetales; Phaffomycetaceae; Wickerhamomyces.
OX NCBI_TaxID=1156965;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=21;
RX PubMed=8536312; DOI=10.1007/BF00311880;
RA Sekito T., Okamoto K., Kitano H., Yoshida K.;
RT "The complete mitochondrial DNA sequence of Hansenula wingei reveals
RT new characteristics of yeast mitochondria.";
RL Curr. Genet. 28:39-53(1995).
CC -!- FUNCTION: Cytochrome c oxidase is the component of the respiratory
CC chain that catalyzes the reduction of oxygen to water. Subunits 1-
CC 3 form the functional core of the enzyme complex. Subunit 2
CC transfers the electrons from cytochrome c via its binuclear copper
CC A center to the bimetallic center of the catalytic subunit 1.
CC -!- CATALYTIC ACTIVITY: 4 ferrocytochrome c + O(2) + 4 H(+) = 4
CC ferricytochrome c + 2 H(2)O.
CC -!- COFACTOR: Copper A.
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane; Multi-pass
CC membrane protein.
CC -!- PTM: The signal sequence of COX2 is processed by IMP1 (By
CC similarity).
CC -!- SIMILARITY: Belongs to the cytochrome c oxidase subunit 2 family.
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DR EMBL; D31785; BAA06577.2; -; Genomic_DNA.
DR PIR; S58754; S58754.
DR RefSeq; NP_038222.1; NC_001762.1.
DR ProteinModelPortal; P48871; -.
DR GeneID; 800566; -.
DR GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
DR GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0070469; C:respiratory chain; IEA:UniProtKB-KW.
DR GO; GO:0005507; F:copper ion binding; IEA:InterPro.
DR GO; GO:0004129; F:cytochrome-c oxidase activity; IEA:EC.
DR GO; GO:0022900; P:electron transport chain; IEA:UniProtKB-KW.
DR Gene3D; 1.10.287.90; -; 1.
DR Gene3D; 2.60.40.420; -; 1.
DR InterPro; IPR001505; Copper_CuA.
DR InterPro; IPR008972; Cupredoxin.
DR InterPro; IPR014222; Cyt_c_oxidase_su2.
DR InterPro; IPR002429; Cyt_c_oxidase_su2_C.
DR InterPro; IPR011759; Cyt_c_oxidase_su2_TM_dom.
DR Pfam; PF00116; COX2; 1.
DR Pfam; PF02790; COX2_TM; 1.
DR SUPFAM; SSF49503; Cupredoxin; 1.
DR SUPFAM; SSF81464; Cyt_c_oxidase_II-like_TM; 1.
DR TIGRFAMs; TIGR02866; CoxB; 1.
DR PROSITE; PS00078; COX2; 1.
DR PROSITE; PS50857; COX2_CUA; 1.
DR PROSITE; PS50999; COX2_TM; 1.
PE 3: Inferred from homology;
KW Copper; Electron transport; Membrane; Metal-binding; Mitochondrion;
KW Mitochondrion inner membrane; Oxidoreductase; Respiratory chain;
KW Signal; Transmembrane; Transmembrane helix; Transport.
FT SIGNAL 1 11 By similarity.
FT CHAIN 12 247 Cytochrome c oxidase subunit 2.
FT /FTId=PRO_0000006038.
FT TOPO_DOM 12 38 Mitochondrial intermembrane (Potential).
FT TRANSMEM 39 59 Helical; (Potential).
FT TOPO_DOM 60 78 Mitochondrial matrix (Potential).
FT TRANSMEM 79 101 Helical; (Potential).
FT TOPO_DOM 102 247 Mitochondrial intermembrane (Potential).
FT METAL 182 182 Copper A (Probable).
FT METAL 217 217 Copper A (Probable).
FT METAL 221 221 Copper A (Probable).
FT METAL 225 225 Copper A (Probable).
SQ SEQUENCE 247 AA; 27809 MW; C41D811809897DDD CRC64;
MLLIINNIIN NDVPTPWGVY FQDSATPNHE GIIELHDNIM FYLVLILCLV SWLLFSIVKD
GSKNPLPHKY LVHGQTIEII WTILPALVLL VIAFPSFILL YLCDEVISPA MTIKAIGLQW
YWKYEYSDFI NDSGETIEFE SYVIPEDLLE DGQLPLLDTD TSIVCPVNTH IRFIVSAADV
IHDFAVPSLG IKIDACPGRL NQVSALIQRE GVYYGQCSEL CGVAHSAMPI KVEAVSLKEF
LTWLNEQ
//
