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Database: UniProt
Entry: P48889
LinkDB: P48889
Original site: P48889 
ID   COX2_ALBCA              Reviewed;         224 AA.
AC   P48889;
DT   01-FEB-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1996, sequence version 1.
DT   01-OCT-2014, entry version 88.
DE   RecName: Full=Cytochrome c oxidase subunit 2;
DE            EC=1.9.3.1;
DE   AltName: Full=Cytochrome c oxidase polypeptide II;
GN   Name=COII;
OS   Albinaria caerulea (Land snail).
OG   Mitochondrion.
OC   Eukaryota; Metazoa; Lophotrochozoa; Mollusca; Gastropoda;
OC   Heterobranchia; Euthyneura; Panpulmonata; Eupulmonata;
OC   Stylommatophora; Sigmurethra; Clausilioidea; Clausiliidae; Alopiinae;
OC   Albinaria.
OX   NCBI_TaxID=42349;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=7498775;
RA   Hatzoglou E., Rodakis G.C., Lecanidou R.;
RT   "Complete sequence and gene organization of the mitochondrial genome
RT   of the land snail Albinaria coerulea.";
RL   Genetics 140:1353-1366(1995).
CC   -!- FUNCTION: Cytochrome c oxidase is the component of the respiratory
CC       chain that catalyzes the reduction of oxygen to water. Subunits 1-
CC       3 form the functional core of the enzyme complex. Subunit 2
CC       transfers the electrons from cytochrome c via its binuclear copper
CC       A center to the bimetallic center of the catalytic subunit 1.
CC   -!- CATALYTIC ACTIVITY: 4 ferrocytochrome c + O(2) + 4 H(+) = 4
CC       ferricytochrome c + 2 H(2)O.
CC   -!- COFACTOR: Copper A.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane; Multi-pass
CC       membrane protein.
CC   -!- SIMILARITY: Belongs to the cytochrome c oxidase subunit 2 family.
CC       {ECO:0000305}.
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DR   EMBL; X83390; CAA58300.1; -; Genomic_DNA.
DR   PIR; S59147; S59147.
DR   RefSeq; NP_007333.1; NC_001761.1.
DR   ProteinModelPortal; P48889; -.
DR   GeneID; 808005; -.
DR   CTD; 4513; -.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0070469; C:respiratory chain; IEA:UniProtKB-KW.
DR   GO; GO:0005507; F:copper ion binding; IEA:InterPro.
DR   GO; GO:0004129; F:cytochrome-c oxidase activity; IEA:UniProtKB-EC.
DR   GO; GO:0022900; P:electron transport chain; IEA:InterPro.
DR   Gene3D; 1.10.287.90; -; 1.
DR   Gene3D; 2.60.40.420; -; 1.
DR   InterPro; IPR001505; Copper_CuA.
DR   InterPro; IPR008972; Cupredoxin.
DR   InterPro; IPR002429; Cyt_c_oxidase_su2_C.
DR   InterPro; IPR011759; Cyt_c_oxidase_su2_TM_dom.
DR   Pfam; PF00116; COX2; 1.
DR   Pfam; PF02790; COX2_TM; 1.
DR   SUPFAM; SSF49503; SSF49503; 1.
DR   SUPFAM; SSF81464; SSF81464; 1.
DR   PROSITE; PS00078; COX2; 1.
DR   PROSITE; PS50857; COX2_CUA; 1.
DR   PROSITE; PS50999; COX2_TM; 1.
PE   3: Inferred from homology;
KW   Copper; Electron transport; Membrane; Metal-binding; Mitochondrion;
KW   Mitochondrion inner membrane; Oxidoreductase; Respiratory chain;
KW   Transmembrane; Transmembrane helix; Transport.
FT   CHAIN         1    224       Cytochrome c oxidase subunit 2.
FT                                /FTId=PRO_0000183487.
FT   TOPO_DOM      1     26       Mitochondrial intermembrane.
FT                                {ECO:0000255}.
FT   TRANSMEM     27     48       Helical. {ECO:0000305}.
FT   TOPO_DOM     49     62       Mitochondrial matrix. {ECO:0000255}.
FT   TRANSMEM     63     82       Helical. {ECO:0000305}.
FT   TOPO_DOM     83    224       Mitochondrial intermembrane.
FT                                {ECO:0000255}.
FT   METAL       161    161       Copper A. {ECO:0000305}.
FT   METAL       196    196       Copper A. {ECO:0000305}.
FT   METAL       200    200       Copper A. {ECO:0000305}.
FT   METAL       204    204       Copper A. {ECO:0000305}.
SQ   SEQUENCE   224 AA;  25247 MW;  BD1BC99250F2429A CRC64;
     MSTWGQINLM DPASPIQMEM MLFHDHAMAI LIGIFTLVSL LGVKLCFNTL STRTMHEAQL
     LETLWTILPA FLLVWLALPS LRLLYLLDEQ GSEGIILKAI GHQWYWSYEM PSMNISNFDS
     YMIPEEDLKP GDYRLLEVDN RPMVPYGLDI NVITTSADVI HAWALPSMGV KMDAVPGRLN
     SMGFHANLPG IYYGQCSEIC GANHSFMPIT VEAIDVKDFI KMCN
//
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