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Database: UniProt
Entry: P49096
LinkDB: P49096
Original site: P49096 
ID   CYB5_MUSDO              Reviewed;         134 AA.
AC   P49096;
DT   01-FEB-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1996, sequence version 1.
DT   29-OCT-2014, entry version 75.
DE   RecName: Full=Cytochrome b5;
DE            Short=CYTB5;
GN   Name=Cyt-b5;
OS   Musca domestica (House fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
OC   Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha;
OC   Muscoidea; Muscidae; Musca.
OX   NCBI_TaxID=7370;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=Rutgers;
RA   Guzov V., Feyereisen R.;
RL   Submitted (DEC-1994) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Cytochrome b5 is a membrane bound hemoprotein which
CC       function as an electron carrier for several membrane bound
CC       oxygenases.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC       {ECO:0000250}; Single-pass membrane protein {ECO:0000250};
CC       Cytoplasmic side {ECO:0000250}. Microsome membrane {ECO:0000250};
CC       Single-pass membrane protein {ECO:0000250}; Cytoplasmic side
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the cytochrome b5 family. {ECO:0000305}.
CC   -!- SIMILARITY: Contains 1 cytochrome b5 heme-binding domain.
CC       {ECO:0000255|PROSITE-ProRule:PRU00279}.
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DR   EMBL; L38464; AAA56985.1; -; mRNA.
DR   RefSeq; NP_001274474.1; NM_001287545.1.
DR   RefSeq; XP_005176043.1; XM_005175986.1.
DR   PDB; 2IBJ; X-ray; 1.55 A; A=1-88.
DR   PDBsum; 2IBJ; -.
DR   ProteinModelPortal; P49096; -.
DR   SMR; P49096; 3-88.
DR   GeneID; 101896437; -.
DR   EvolutionaryTrace; P49096; -.
DR   GO; GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-KW.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0020037; F:heme binding; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0055114; P:oxidation-reduction process; IEA:UniProtKB-KW.
DR   Gene3D; 3.10.120.10; -; 1.
DR   InterPro; IPR001199; Cyt_B5-like_heme/steroid-bd.
DR   InterPro; IPR018506; Cyt_B5_heme-BS.
DR   Pfam; PF00173; Cyt-b5; 1.
DR   PRINTS; PR00363; CYTOCHROMEB5.
DR   SUPFAM; SSF55856; SSF55856; 1.
DR   PROSITE; PS00191; CYTOCHROME_B5_1; 1.
DR   PROSITE; PS50255; CYTOCHROME_B5_2; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Electron transport; Endoplasmic reticulum; Heme; Iron;
KW   Membrane; Metal-binding; Microsome; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN         1    134       Cytochrome b5.
FT                                /FTId=PRO_0000166017.
FT   TRANSMEM    111    131       Helical. {ECO:0000255}.
FT   DOMAIN        6     82       Cytochrome b5 heme-binding.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00279}.
FT   METAL        41     41       Iron (heme axial ligand).
FT                                {ECO:0000255|PROSITE-ProRule:PRU00279}.
FT   METAL        65     65       Iron (heme axial ligand).
FT                                {ECO:0000255|PROSITE-ProRule:PRU00279}.
FT   HELIX        11     15       {ECO:0000244|PDB:2IBJ}.
FT   STRAND       17     19       {ECO:0000244|PDB:2IBJ}.
FT   STRAND       22     27       {ECO:0000244|PDB:2IBJ}.
FT   STRAND       30     33       {ECO:0000244|PDB:2IBJ}.
FT   HELIX        35     37       {ECO:0000244|PDB:2IBJ}.
FT   TURN         38     40       {ECO:0000244|PDB:2IBJ}.
FT   HELIX        46     49       {ECO:0000244|PDB:2IBJ}.
FT   TURN         50     53       {ECO:0000244|PDB:2IBJ}.
FT   HELIX        57     63       {ECO:0000244|PDB:2IBJ}.
FT   HELIX        67     73       {ECO:0000244|PDB:2IBJ}.
FT   HELIX        74     76       {ECO:0000244|PDB:2IBJ}.
FT   STRAND       77     81       {ECO:0000244|PDB:2IBJ}.
FT   HELIX        83     85       {ECO:0000244|PDB:2IBJ}.
SQ   SEQUENCE   134 AA;  15401 MW;  11A1A23E235EC3AA CRC64;
     MSSEDVKYFT RAEVAKNNTK DKNWFIIHNN VYDVTAFLNE HPGGEEVLIE QAGKDATEHF
     EDVGHSSDAR EMMKQYKVGE LVAEERSNVP EKSEPTWNTE QKTEESSMKS WLMPFVLGLV
     ATLIYKFFFG TKSQ
//
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