ID CYB5_MUSDO Reviewed; 134 AA.
AC P49096;
DT 01-FEB-1996, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1996, sequence version 1.
DT 06-MAR-2013, entry version 70.
DE RecName: Full=Cytochrome b5;
DE Short=CYTB5;
GN Name=Cyt-b5;
OS Musca domestica (House fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
OC Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha;
OC Muscoidea; Muscidae; Musca.
OX NCBI_TaxID=7370;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=Rutgers;
RA Guzov V., Feyereisen R.;
RL Submitted (DEC-1994) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Cytochrome b5 is a membrane bound hemoprotein which
CC function as an electron carrier for several membrane bound
CC oxygenases.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Single-pass
CC membrane protein; Cytoplasmic side (By similarity). Microsome
CC membrane; Single-pass membrane protein; Cytoplasmic side (By
CC similarity).
CC -!- SIMILARITY: Belongs to the cytochrome b5 family.
CC -!- SIMILARITY: Contains 1 cytochrome b5 heme-binding domain.
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DR EMBL; L38464; AAA56985.1; -; mRNA.
DR PDB; 2IBJ; X-ray; 1.55 A; A=1-88.
DR PDBsum; 2IBJ; -.
DR ProteinModelPortal; P49096; -.
DR SMR; P49096; 3-88.
DR EvolutionaryTrace; P49096; -.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
DR GO; GO:0020037; F:heme binding; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0022900; P:electron transport chain; IEA:UniProtKB-KW.
DR Gene3D; 3.10.120.10; -; 1.
DR InterPro; IPR001199; Cyt_B5-like_heme/steroid-bd.
DR InterPro; IPR018506; Cyt_B5_heme-BS.
DR Pfam; PF00173; Cyt-b5; 1.
DR PRINTS; PR00363; CYTOCHROMEB5.
DR SUPFAM; SSF55856; Cyt_B5; 1.
DR PROSITE; PS00191; CYTOCHROME_B5_1; 1.
DR PROSITE; PS50255; CYTOCHROME_B5_2; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Electron transport; Endoplasmic reticulum; Heme; Iron;
KW Membrane; Metal-binding; Microsome; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1 134 Cytochrome b5.
FT /FTId=PRO_0000166017.
FT TRANSMEM 111 131 Helical; (Potential).
FT DOMAIN 6 82 Cytochrome b5 heme-binding.
FT METAL 41 41 Iron (heme axial ligand) (By similarity).
FT METAL 65 65 Iron (heme axial ligand) (By similarity).
FT HELIX 11 15
FT STRAND 17 19
FT STRAND 22 27
FT STRAND 30 33
FT HELIX 35 37
FT TURN 38 40
FT HELIX 46 49
FT TURN 50 53
FT HELIX 57 63
FT HELIX 67 73
FT HELIX 74 76
FT STRAND 77 81
FT HELIX 83 85
SQ SEQUENCE 134 AA; 15401 MW; 11A1A23E235EC3AA CRC64;
MSSEDVKYFT RAEVAKNNTK DKNWFIIHNN VYDVTAFLNE HPGGEEVLIE QAGKDATEHF
EDVGHSSDAR EMMKQYKVGE LVAEERSNVP EKSEPTWNTE QKTEESSMKS WLMPFVLGLV
ATLIYKFFFG TKSQ
//
