GenomeNet

Database: UniProt
Entry: P49096
LinkDB: P49096
Original site: P49096 
ID   CYB5_MUSDO              Reviewed;         134 AA.
AC   P49096;
DT   01-FEB-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1996, sequence version 1.
DT   01-OCT-2014, entry version 74.
DE   RecName: Full=Cytochrome b5;
DE            Short=CYTB5;
GN   Name=Cyt-b5;
OS   Musca domestica (House fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
OC   Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha;
OC   Muscoidea; Muscidae; Musca.
OX   NCBI_TaxID=7370;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=Rutgers;
RA   Guzov V., Feyereisen R.;
RL   Submitted (DEC-1994) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Cytochrome b5 is a membrane bound hemoprotein which
CC       function as an electron carrier for several membrane bound
CC       oxygenases.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC       {ECO:0000250}; Single-pass membrane protein {ECO:0000250};
CC       Cytoplasmic side {ECO:0000250}. Microsome membrane {ECO:0000250};
CC       Single-pass membrane protein {ECO:0000250}; Cytoplasmic side
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the cytochrome b5 family. {ECO:0000305}.
CC   -!- SIMILARITY: Contains 1 cytochrome b5 heme-binding domain.
CC       {ECO:0000255|PROSITE-ProRule:PRU00279}.
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DR   EMBL; L38464; AAA56985.1; -; mRNA.
DR   RefSeq; NP_001274474.1; NM_001287545.1.
DR   RefSeq; XP_005176043.1; XM_005175986.1.
DR   PDB; 2IBJ; X-ray; 1.55 A; A=1-88.
DR   PDBsum; 2IBJ; -.
DR   ProteinModelPortal; P49096; -.
DR   SMR; P49096; 3-88.
DR   GeneID; 101896437; -.
DR   EvolutionaryTrace; P49096; -.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0020037; F:heme binding; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0055114; P:oxidation-reduction process; IEA:UniProtKB-KW.
DR   Gene3D; 3.10.120.10; -; 1.
DR   InterPro; IPR001199; Cyt_B5-like_heme/steroid-bd.
DR   InterPro; IPR018506; Cyt_B5_heme-BS.
DR   Pfam; PF00173; Cyt-b5; 1.
DR   PRINTS; PR00363; CYTOCHROMEB5.
DR   SUPFAM; SSF55856; SSF55856; 1.
DR   PROSITE; PS00191; CYTOCHROME_B5_1; 1.
DR   PROSITE; PS50255; CYTOCHROME_B5_2; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Electron transport; Endoplasmic reticulum; Heme; Iron;
KW   Membrane; Metal-binding; Microsome; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN         1    134       Cytochrome b5.
FT                                /FTId=PRO_0000166017.
FT   TRANSMEM    111    131       Helical. {ECO:0000255}.
FT   DOMAIN        6     82       Cytochrome b5 heme-binding.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00279}.
FT   METAL        41     41       Iron (heme axial ligand).
FT                                {ECO:0000255|PROSITE-ProRule:PRU00279}.
FT   METAL        65     65       Iron (heme axial ligand).
FT                                {ECO:0000255|PROSITE-ProRule:PRU00279}.
FT   HELIX        11     15
FT   STRAND       17     19
FT   STRAND       22     27
FT   STRAND       30     33
FT   HELIX        35     37
FT   TURN         38     40
FT   HELIX        46     49
FT   TURN         50     53
FT   HELIX        57     63
FT   HELIX        67     73
FT   HELIX        74     76
FT   STRAND       77     81
FT   HELIX        83     85
SQ   SEQUENCE   134 AA;  15401 MW;  11A1A23E235EC3AA CRC64;
     MSSEDVKYFT RAEVAKNNTK DKNWFIIHNN VYDVTAFLNE HPGGEEVLIE QAGKDATEHF
     EDVGHSSDAR EMMKQYKVGE LVAEERSNVP EKSEPTWNTE QKTEESSMKS WLMPFVLGLV
     ATLIYKFFFG TKSQ
//
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