ID HXA9_AMBME Reviewed; 143 AA.
AC P50209;
DT 01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-1996, sequence version 1.
DT 03-APR-2013, entry version 65.
DE RecName: Full=Homeobox protein Hox-A9;
DE Flags: Fragment;
GN Name=HOXA9;
OS Ambystoma mexicanum (Axolotl).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Amphibia; Batrachia; Caudata; Salamandroidea; Ambystomatidae;
OC Ambystoma.
OX NCBI_TaxID=8296;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Regenerating limb blastema;
RX PubMed=7600989;
RA Gardiner D.M., Blumberg B., Komine Y., Bryant S.V.;
RT "Regulation of HoxA expression in developing and regenerating axolotl
RT limbs.";
RL Development 121:1731-1741(1995).
CC -!- FUNCTION: Sequence-specific transcription factor which is part of
CC a developmental regulatory system that provides cells with
CC specific positional identities on the anterior-posterior axis (By
CC similarity).
CC -!- SUBCELLULAR LOCATION: Nucleus.
CC -!- SIMILARITY: Belongs to the Abd-B homeobox family.
CC -!- SIMILARITY: Contains 1 homeobox DNA-binding domain.
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DR EMBL; U20941; AAA86505.1; -; mRNA.
DR ProteinModelPortal; P50209; -.
DR SMR; P50209; 66-142.
DR HOVERGEN; HBG016849; -.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR GO; GO:0003700; F:sequence-specific DNA binding transcription factor activity; IEA:InterPro.
DR GO; GO:0007275; P:multicellular organismal development; IEA:UniProtKB-KW.
DR GO; GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
DR Gene3D; 1.10.10.60; -; 1.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR020479; Homeobox_metazoa.
DR InterPro; IPR001356; Homeodomain.
DR InterPro; IPR009057; Homeodomain-like.
DR InterPro; IPR006711; Hox9_activation_N.
DR Pfam; PF00046; Homeobox; 1.
DR Pfam; PF04617; Hox9_act; 1.
DR PRINTS; PR00024; HOMEOBOX.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; Homeodomain_like; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 2: Evidence at transcript level;
KW Developmental protein; DNA-binding; Homeobox; Nucleus; Transcription;
KW Transcription regulation.
FT CHAIN <1 143 Homeobox protein Hox-A9.
FT /FTId=PRO_0000200089.
FT DNA_BIND 78 137 Homeobox.
FT NON_TER 1 1
SQ SEQUENCE 143 AA; 16592 MW; 83ED182CEE573773 CRC64;
RHYGIKPEPL PPGTRRGDCT TFDSSHTLSL SDYGSSPADK QSSEGAFPEA PAETEASGDK
PAIDPNNPAA NWLHARSTRK KRCPYTKHQT LELEKEFLFN MYLTRDRRYE VARLLNLTER
QVKIWFQNRR MKMKKINKDR PKE
//
