ID PSPB_MOUSE Reviewed; 377 AA.
AC P50405;
DT 01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-1996, sequence version 1.
DT 29-MAY-2013, entry version 99.
DE RecName: Full=Pulmonary surfactant-associated protein B;
DE Short=SP-B;
DE AltName: Full=Pulmonary surfactant-associated proteolipid SPL(Phe);
DE Flags: Precursor;
GN Name=Sftpb; Synonyms=Sftp3;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;
OC Muroidea; Muridae; Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=DBA/2J; TISSUE=Liver;
RX PubMed=7900819;
RA Bruno M.A., Bohinski R.J., Carter J.E., Foss K.A., Whitsett J.A.;
RT "Structure and function of the mouse surfactant protein B gene.";
RL Am. J. Physiol. 268:L381-L389(1995).
CC -!- FUNCTION: Pulmonary surfactant-associated proteins promote
CC alveolar stability by lowering the surface tension at the air-
CC liquid interface in the peripheral air spaces. SP-B increases the
CC collapse pressure of palmitic acid to nearly 70 millinewtons per
CC meter.
CC -!- SUBUNIT: Homodimer; disulfide-linked.
CC -!- SUBCELLULAR LOCATION: Secreted, extracellular space, surface film.
CC -!- MISCELLANEOUS: Pulmonary surfactant consists of 90% lipid and 10%
CC protein. There are 4 surfactant-associated proteins: 2
CC collagenous, carbohydrate-binding glycoproteins (SP-A and SP-D)
CC and 2 small hydrophobic proteins (SP-B and SP-C).
CC -!- SIMILARITY: Contains 1 saposin A-type domain.
CC -!- SIMILARITY: Contains 3 saposin B-type domains.
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DR EMBL; S78114; AAB34846.2; -; Genomic_DNA.
DR IPI; IPI00117977; -.
DR RefSeq; NP_680088.1; NM_147779.1.
DR UniGene; Mm.46033; -.
DR ProteinModelPortal; P50405; -.
DR SMR; P50405; 68-142.
DR MINT; MINT-4109008; -.
DR STRING; 10090.ENSMUSP00000066805; -.
DR PaxDb; P50405; -.
DR PRIDE; P50405; -.
DR GeneID; 20388; -.
DR KEGG; mmu:20388; -.
DR UCSC; uc009cid.1; mouse.
DR CTD; 6439; -.
DR MGI; MGI:109516; Sftpb.
DR eggNOG; NOG286450; -.
DR HOGENOM; HOG000115745; -.
DR HOVERGEN; HBG006905; -.
DR InParanoid; P50405; -.
DR OrthoDB; EOG434W6C; -.
DR NextBio; 298318; -.
DR ArrayExpress; P50405; -.
DR Bgee; P50405; -.
DR CleanEx; MM_SFTPB; -.
DR Genevestigator; P50405; -.
DR GermOnline; ENSMUSG00000056370; Mus musculus.
DR GO; GO:0005737; C:cytoplasm; IDA:MGI.
DR GO; GO:0005615; C:extracellular space; IEA:UniProtKB-SubCell.
DR GO; GO:0005764; C:lysosome; IEA:InterPro.
DR GO; GO:0007585; P:respiratory gaseous exchange; IEA:UniProtKB-KW.
DR GO; GO:0006665; P:sphingolipid metabolic process; IEA:InterPro.
DR Gene3D; 1.10.225.10; -; 3.
DR InterPro; IPR003119; SapA.
DR InterPro; IPR007856; SapB_1.
DR InterPro; IPR008138; SapB_2.
DR InterPro; IPR008373; Saposin.
DR InterPro; IPR011001; Saposin-like.
DR InterPro; IPR008139; SaposinB.
DR Pfam; PF02199; SapA; 1.
DR Pfam; PF05184; SapB_1; 1.
DR Pfam; PF03489; SapB_2; 2.
DR PRINTS; PR01797; SAPOSIN.
DR SMART; SM00162; SAPA; 1.
DR SMART; SM00741; SapB; 3.
DR SUPFAM; SSF47862; Saposin_like; 3.
DR PROSITE; PS51110; SAP_A; 1.
DR PROSITE; PS50015; SAP_B; 3.
PE 2: Evidence at transcript level;
KW Complete proteome; Disulfide bond; Gaseous exchange; Glycoprotein;
KW Reference proteome; Repeat; Secreted; Signal; Surface film.
FT SIGNAL 1 22 Potential.
FT PROPEP 23 191
FT /FTId=PRO_0000031650.
FT CHAIN 192 270 Pulmonary surfactant-associated protein
FT B.
FT /FTId=PRO_0000031651.
FT PROPEP 271 377
FT /FTId=PRO_0000031652.
FT DOMAIN 24 64 Saposin A-type.
FT DOMAIN 64 146 Saposin B-type 1.
FT DOMAIN 195 272 Saposin B-type 2.
FT DOMAIN 291 366 Saposin B-type 3.
FT CARBOHYD 307 307 N-linked (GlcNAc...) (Potential).
FT DISULFID 68 142 By similarity.
FT DISULFID 71 136 By similarity.
FT DISULFID 99 111 By similarity.
FT DISULFID 199 268 By similarity.
FT DISULFID 202 262 By similarity.
FT DISULFID 226 237 By similarity.
FT DISULFID 239 239 Interchain (By similarity).
FT DISULFID 295 362 By similarity.
FT DISULFID 298 356 By similarity.
FT DISULFID 321 331 By similarity.
SQ SEQUENCE 377 AA; 41728 MW; CB687A82BA3FC56C CRC64;
MAKSHLLQWL LLLPTLCCPG AAITSASSLE CAQGPQFWCQ SLEHAVQCRA LGHCLQEVWG
HAGANDLCQE CEDIVHLLTK MTKEDAFQEA IRKFLEQECD ILPLKLLVPR CRQVLDVYLP
LVIDYFQSQI NPKAICNHVG LCPRGQAKPE QNPGMPDAVP NPLLDKLVLP VLPGALLARP
GPHTQDFSEQ QLPIPLPFCW LCRTLIKRVQ AVIPKGVLAV AVSQVCHVVP LVVGGICQCL
AERYTVLLLD ALLGRVVPQL VCGLVLRCST EDAMGPALPA VEPLIEEWPL QDTECHFCKS
VINQAWNTSE QAMPQAMHQA CLRFWLDRQK CEQFVEQHMP QLLALVPRSQ DAHITCQALG
VCEAPASPLQ CFQTPHL
//
