ID DLX5_CHICK Reviewed; 286 AA.
AC P50577; Q549L3;
DT 01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-1996, sequence version 1.
DT 27-MAR-2024, entry version 144.
DE RecName: Full=Homeobox protein DLX-5;
DE Short=cDlx;
GN Name=DLX5; Synonyms=DLX-5;
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=White leghorn;
RX PubMed=8541214; DOI=10.1016/0925-4773(95)98113-o;
RA Ferrari D., Sumoy L., Gannon J., Sun H., Brown A.M., Upholt W.B.,
RA Kosher R.A.;
RT "The expression pattern of the Distal-less homeobox-containing gene Dlx-5
RT in the developing chick limb bud suggests its involvement in apical
RT ectodermal ridge activity, pattern formation, and cartilage
RT differentiation.";
RL Mech. Dev. 52:257-264(1995).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=White leghorn;
RX PubMed=10894982; DOI=10.1159/000017441;
RA Borghjid S., Siddiqui M.A.Q.;
RT "Chick homeobox gene cDlx expression demarcates the forebrain anlage,
RT indicating the onset of forebrain regional specification at gastrulation.";
RL Dev. Neurosci. 22:183-196(2000).
CC -!- FUNCTION: Transcriptional factor involved in bone development. Could be
CC involved in apical ectodermal ridge activity, pattern formation, and
CC cartilage differentiation. Binds to DNA.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
CC -!- SIMILARITY: Belongs to the distal-less homeobox family. {ECO:0000305}.
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DR EMBL; U25274; AAA96145.1; -; mRNA.
DR EMBL; AF096161; AAF00085.1; -; mRNA.
DR RefSeq; NP_989490.1; NM_204159.1.
DR AlphaFoldDB; P50577; -.
DR BMRB; P50577; -.
DR SMR; P50577; -.
DR STRING; 9031.ENSGALP00000014846; -.
DR PaxDb; 9031-ENSGALP00000014846; -.
DR Ensembl; ENSGALT00000014862; ENSGALP00000014846; ENSGALG00000009129.
DR Ensembl; ENSGALT00010006891.1; ENSGALP00010004206.1; ENSGALG00010002959.1.
DR Ensembl; ENSGALT00015008296; ENSGALP00015004715; ENSGALG00015003637.
DR GeneID; 373969; -.
DR KEGG; gga:373969; -.
DR CTD; 1749; -.
DR VEuPathDB; HostDB:geneid_373969; -.
DR eggNOG; KOG0850; Eukaryota.
DR GeneTree; ENSGT00940000159188; -.
DR HOGENOM; CLU_074733_0_0_1; -.
DR InParanoid; P50577; -.
DR OMA; THGYCSP; -.
DR OrthoDB; 2969529at2759; -.
DR PhylomeDB; P50577; -.
DR TreeFam; TF350606; -.
DR PRO; PR:P50577; -.
DR Proteomes; UP000000539; Chromosome 2.
DR Bgee; ENSGALG00000009129; Expressed in brain.
DR GO; GO:0000785; C:chromatin; IEA:Ensembl.
DR GO; GO:0005737; C:cytoplasm; IEA:Ensembl.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; IEA:Ensembl.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0071837; F:HMG box domain binding; IEA:Ensembl.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0048646; P:anatomical structure formation involved in morphogenesis; IBA:GO_Central.
DR GO; GO:0030509; P:BMP signaling pathway; IEA:Ensembl.
DR GO; GO:0030154; P:cell differentiation; IBA:GO_Central.
DR GO; GO:0008283; P:cell population proliferation; IEA:Ensembl.
DR GO; GO:0030326; P:embryonic limb morphogenesis; IEA:Ensembl.
DR GO; GO:0001958; P:endochondral ossification; IEA:Ensembl.
DR GO; GO:0030855; P:epithelial cell differentiation; IEA:Ensembl.
DR GO; GO:0060325; P:face morphogenesis; IEA:Ensembl.
DR GO; GO:0042472; P:inner ear morphogenesis; IEA:Ensembl.
DR GO; GO:0097376; P:interneuron axon guidance; IEA:Ensembl.
DR GO; GO:0021889; P:olfactory bulb interneuron differentiation; IEA:Ensembl.
DR GO; GO:0060166; P:olfactory pit development; IEA:Ensembl.
DR GO; GO:0001649; P:osteoblast differentiation; IEA:Ensembl.
DR GO; GO:0090263; P:positive regulation of canonical Wnt signaling pathway; IEA:Ensembl.
DR GO; GO:0050679; P:positive regulation of epithelial cell proliferation; IEA:Ensembl.
DR GO; GO:0010628; P:positive regulation of gene expression; IEA:Ensembl.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0060021; P:roof of mouth development; IEA:Ensembl.
DR CDD; cd00086; homeodomain; 1.
DR Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR InterPro; IPR022135; Distal-less_N.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR020479; Homeobox_metazoa.
DR InterPro; IPR000047; HTH_motif.
DR PANTHER; PTHR24327; HOMEOBOX PROTEIN; 1.
DR PANTHER; PTHR24327:SF31; HOMEOBOX PROTEIN DLX-5; 1.
DR Pfam; PF12413; DLL_N; 1.
DR Pfam; PF00046; Homeodomain; 1.
DR PRINTS; PR00024; HOMEOBOX.
DR PRINTS; PR00031; HTHREPRESSR.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; Homeodomain-like; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 2: Evidence at transcript level;
KW Developmental protein; DNA-binding; Homeobox; Nucleus; Osteogenesis;
KW Reference proteome; Transcription; Transcription regulation.
FT CHAIN 1..286
FT /note="Homeobox protein DLX-5"
FT /id="PRO_0000049030"
FT DNA_BIND 136..195
FT /note="Homeobox"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT REGION 1..52
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 197..286
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 16..48
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 202..226
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 286 AA; 30949 MW; 5A694A07207573DF CRC64;
MTAVFDRRVP GIRSSDFQPP FQSAAAMHHP SQESPTLPES SATDSDYYSP TGAAPHGYCS
PTSASYGKAL NPYQYQYGMN GSAGTYPAKA YADYGYGSPY HQYGGAYGRG QSSAGQPEKE
VAEPEVRMVN GKPKKVRKPR TIYSSFQLAA LQRRFQKTQY LALPERAELA ASLGLTQTQV
KIWFQNKRSK IKKIMKNGEM PPEHSPSSSD PMACNSPQSP AVWEPQGSSR SLGHHGHGHP
PAANPSPGSY LESPSAWYPA ASPLGSHLQP HGSLQHPLAL PSGTIY
//
