ID CISY_BARQU Reviewed; 438 AA.
AC P51034; Q6FZN8;
DT 01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT 16-AUG-2004, sequence version 3.
DT 29-MAY-2013, entry version 80.
DE RecName: Full=Citrate synthase;
DE EC=2.3.3.1;
GN Name=gltA; OrderedLocusNames=BQ06850;
OS Bartonella quintana (strain Toulouse) (Rochalimaea quintana).
OC Bacteria; Proteobacteria; Alphaproteobacteria; Rhizobiales;
OC Bartonellaceae; Bartonella.
OX NCBI_TaxID=283165;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Toulouse;
RX PubMed=15210978; DOI=10.1073/pnas.0305659101;
RA Alsmark U.C.M., Frank A.C., Karlberg E.O., Legault B.-A., Ardell D.H.,
RA Canbaeck B., Eriksson A.-S., Naeslund A.K., Handley S.A., Huvet M.,
RA La Scola B., Holmberg M., Andersson S.G.E.;
RT "The louse-borne human pathogen Bartonella quintana is a genomic
RT derivative of the zoonotic agent Bartonella henselae.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:9716-9721(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 60-379.
RC STRAIN=ATCC VR-358 / Fuller / CIP 107027;
RX PubMed=8863415;
RA Birtles R.J., Raoult D.;
RT "Comparison of partial citrate synthase gene (gltA) sequences for
RT phylogenetic analysis of Bartonella species.";
RL Int. J. Syst. Bacteriol. 46:891-897(1996).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 268-379.
RC STRAIN=ATCC VR-358 / Fuller / CIP 107027;
RA Jones D.C., Regnery R., Bowen M.;
RT "Bartonella species characterization: citrate synthase (gltA) PCR
RT product sequence analysis.";
RL Submitted (MAY-1995) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY: Acetyl-CoA + H(2)O + oxaloacetate = citrate +
CC CoA.
CC -!- PATHWAY: Carbohydrate metabolism; tricarboxylic acid cycle;
CC isocitrate from oxaloacetate: step 1/2.
CC -!- MISCELLANEOUS: Citrate synthase is found in nearly all cells
CC capable of oxidative metabolism.
CC -!- SIMILARITY: Belongs to the citrate synthase family.
CC -----------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution-NoDerivs License
CC -----------------------------------------------------------------------
DR EMBL; BX897700; CAF26174.1; -; Genomic_DNA.
DR EMBL; Z70014; CAA93836.1; -; Genomic_DNA.
DR EMBL; U28073; AAA74978.1; -; Genomic_DNA.
DR RefSeq; YP_032322.1; NC_005955.1.
DR ProteinModelPortal; P51034; -.
DR SMR; P51034; 2-429.
DR STRING; 283165.BQ06850; -.
DR PRIDE; P51034; -.
DR EnsemblBacteria; CAF26174; CAF26174; BQ06850.
DR GeneID; 2867054; -.
DR KEGG; bqu:BQ06850; -.
DR PATRIC; 31952667; VBIBarQui58630_0759.
DR eggNOG; COG0372; -.
DR HOGENOM; HOG000021224; -.
DR KO; K01647; -.
DR OMA; RVTHHTM; -.
DR ProtClustDB; PRK05614; -.
DR BioCyc; BQUI283165:GHZA-684-MONOMER; -.
DR UniPathway; UPA00223; UER00717.
DR GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR GO; GO:0004108; F:citrate (Si)-synthase activity; IEA:EC.
DR GO; GO:0044262; P:cellular carbohydrate metabolic process; IEA:InterPro.
DR GO; GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-UniPathway.
DR Gene3D; 1.10.230.10; -; 1.
DR Gene3D; 1.10.580.10; -; 1.
DR InterPro; IPR016142; Citrate_synth-like_lrg_a-sub.
DR InterPro; IPR016143; Citrate_synth-like_sm_a-sub.
DR InterPro; IPR002020; Citrate_synthase-like.
DR InterPro; IPR016141; Citrate_synthase-like_core.
DR InterPro; IPR019810; Citrate_synthase_AS.
DR InterPro; IPR024176; Citrate_synthase_bac-typ.
DR InterPro; IPR010953; Citrate_synthase_typ-II.
DR PANTHER; PTHR11739; PTHR11739; 1.
DR Pfam; PF00285; Citrate_synt; 1.
DR PIRSF; PIRSF001369; Citrate_synth; 1.
DR PRINTS; PR00143; CITRTSNTHASE.
DR SUPFAM; SSF48256; Citrate_synthase_core; 1.
DR TIGRFAMs; TIGR01798; cit_synth_I; 1.
DR PROSITE; PS00480; CITRATE_SYNTHASE; 1.
PE 3: Inferred from homology;
KW Complete proteome; Transferase; Tricarboxylic acid cycle.
FT CHAIN 1 438 Citrate synthase.
FT /FTId=PRO_0000169935.
FT ACT_SITE 306 306 By similarity.
FT ACT_SITE 364 364 By similarity.
FT CONFLICT 117 117 Q -> R (in Ref. 2; CAA93836).
FT CONFLICT 224 224 F -> C (in Ref. 2; CAA93836).
SQ SEQUENCE 438 AA; 49464 MW; 98ED2C4A41ACD5E4 CRC64;
MSENKAHITV NNKKIELSVR KGTLGPGVIE IASLYKETDT FTYDPGFTST ASCESKITYI
DGDKGILLYC GYPIDQLAEK GDFLESCYLL LYGELPTKQE KIDFDRCIMQ HMMVHEQFTR
FFHGFRRDSH PMAVMVACLG AMSAFYHDSI DIKDAQQRMI AAIRLISKVP TLAAMAYKYS
IGQAFVYPRN DLSYAANFLH MCFSVPCEEY KINPVLSRAM DRIFTLHADH EQNASTSTVR
LVGSSGANPF ACIAAGVACL WGPAHGGANE ACLKMLQKIG SVERIPEFIA RAKDKNDPFR
LMGFGHRVYK NYDPRAKIMQ QTCHEVLKEL NIQDDPLLDI AIALENTALN DEYFIEKKLY
PNVDFYSGIT LKALGFPTEM FTVLFALARS IGWVAQWKEM IEDPAQKIGR PRQLYTGYAA
REYVSIDKRI SKNKMTTQ
//
