ID GON1_SPAAU Reviewed; 95 AA.
AC P51919;
DT 01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-1996, sequence version 1.
DT 03-APR-2013, entry version 57.
DE RecName: Full=Progonadoliberin-1;
DE AltName: Full=Progonadoliberin I;
DE Contains:
DE RecName: Full=Gonadoliberin-1;
DE AltName: Full=Gonadoliberin I;
DE AltName: Full=Gonadotropin-releasing hormone I;
DE Short=GnRH-I;
DE AltName: Full=Luliberin I;
DE AltName: Full=Luteinizing hormone-releasing hormone I;
DE Short=LH-RH I;
DE Contains:
DE RecName: Full=GnRH-associated peptide 1;
DE AltName: Full=GnRH-associated peptide I;
DE Flags: Precursor;
GN Name=gnrh1;
OS Sparus aurata (Gilthead sea bream).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Euteleostei; Neoteleostei;
OC Acanthomorpha; Acanthopterygii; Percomorpha; Perciformes; Percoidei;
OC Sparidae; Sparus.
OX NCBI_TaxID=8175;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Brain;
RX PubMed=7749463;
RA Gothilf Y., Elizur A., Chow M., Chen T.T., Zohar Y.;
RT "Molecular cloning and characterization of a novel gonadotropin-
RT releasing hormone from the gilthead seabream (Sparus aurata).";
RL Mol. Mar. Biol. Biotechnol. 4:27-35(1995).
RN [2]
RP PROTEIN SEQUENCE OF 26-35, AND MASS SPECTROMETRY.
RC TISSUE=Brain;
RX PubMed=7991588; DOI=10.1073/pnas.91.25.12081;
RA Powell J.F.F., Zohar Y., Elizur A., Park M., Fischer W.H., Craig A.G.,
RA Rivier J.E., Lovejoy D.A., Sherwood N.M.;
RT "Three forms of gonadotropin-releasing hormone characterized from
RT brains of one species.";
RL Proc. Natl. Acad. Sci. U.S.A. 91:12081-12085(1994).
CC -!- FUNCTION: Stimulates the secretion of gonadotropins.
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- MASS SPECTROMETRY: Mass=1113.6; Method=MALDI; Range=26-35;
CC Source=PubMed:7991588;
CC -!- SIMILARITY: Belongs to the GnRH family.
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DR EMBL; U30320; AAA75469.1; -; mRNA.
DR HOVERGEN; HBG014746; -.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0007275; P:multicellular organismal development; IEA:InterPro.
DR InterPro; IPR002012; GnRH.
DR InterPro; IPR019792; Gonadoliberin_I.
DR PANTHER; PTHR10522; PTHR10522; 1.
DR PROSITE; PS00473; GNRH; 1.
PE 1: Evidence at protein level;
KW Amidation; Cleavage on pair of basic residues;
KW Direct protein sequencing; Hormone; Pyrrolidone carboxylic acid;
KW Secreted; Signal.
FT SIGNAL 1 25
FT CHAIN 26 95 Progonadoliberin-1.
FT /FTId=PRO_0000012444.
FT PEPTIDE 26 35 Gonadoliberin-1.
FT /FTId=PRO_0000012445.
FT PEPTIDE 39 95 GnRH-associated peptide 1 (Potential).
FT /FTId=PRO_0000012446.
FT MOD_RES 26 26 Pyrrolidone carboxylic acid.
FT MOD_RES 35 35 Glycine amide.
SQ SEQUENCE 95 AA; 10753 MW; 49313FD6FD6B87DA CRC64;
MAPQTSNLWI LLLLVVVMMM SQGCCQHWSY GLSPGGKRDL DSLSDTLGNI IERFPHVDSP
CSVLGCVEEP HVPRMYRMKG FIGSERDIGH RMYKK
//
