Database: UniProt
Entry: P52211
LinkDB: P52211
Original site: P52211 
ID   PTHR_CANLF              Reviewed;         177 AA.
AC   P52211;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1996, sequence version 1.
DT   30-AUG-2017, entry version 94.
DE   RecName: Full=Parathyroid hormone-related protein;
DE            Short=PTH-rP;
DE            Short=PTHrP;
DE   Contains:
DE     RecName: Full=Osteostatin;
DE   Flags: Precursor;
GN   Name=PTHLH;
OS   Canis lupus familiaris (Dog) (Canis familiaris).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae;
OC   Canis.
OX   NCBI_TaxID=9615;
RN   [1]
RC   TISSUE=Anal sac;
RX   PubMed=7642102; DOI=10.1016/0378-1119(94)00912-C;
RA   Rosol T.J., Steinmeyer C.L., McCauley L.K., Groene A., DeWille J.W.,
RA   Capen C.C.;
RT   "Sequences of the cDNAs encoding canine parathyroid hormone-related
RT   protein and parathyroid hormone.";
RL   Gene 160:241-243(1995).
CC   -!- FUNCTION: Neuroendocrine peptide which is a critical regulator of
CC       cellular and organ growth, development, migration, differentiation
CC       and survival and of epithelial calcium ion transport. Regulates
CC       endochondral bone development and epithelial-mesenchymal
CC       interactions during the formation of the mammary glands and
CC       teethRequired for skeletal homeostasis. Promotes mammary
CC       mesenchyme differentiation and bud outgrowth by modulating
CC       mesenchymal cell responsiveness to BMPs. Upregulates BMPR1A
CC       expression in the mammary mesenchyme and this increases the
CC       sensitivity of these cells to BMPs and allows them to respond to
CC       BMP4 in a paracrine and/or autocrine fashion. BMP4 signaling in
CC       the mesenchyme, in turn, triggers epithelial outgrowth and
CC       augments MSX2 expression, which causes the mammary mesenchyme to
CC       inhibit hair follicle formation within the nipple sheath (By
CC       similarity). {ECO:0000250}.
CC   -!- FUNCTION: Osteostatin is a potent inhibitor of osteoclastic bone
CC       resorption. {ECO:0000250}.
CC   -!- SUBUNIT: PTHrP interacts with PTH1R (via N-terminal extracellular
CC       domain). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus
CC       {ECO:0000250}. Secreted {ECO:0000250}.
CC   -!- PTM: There are several secretory forms, including osteostatin,
CC       arising from endoproteolytic cleavage of the initial translation
CC       product. Each of these secretory forms is believed to have one or
CC       more of its own receptors that mediates the normal paracrine,
CC       autocrine and endocrine actions (By similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the parathyroid hormone family.
CC       {ECO:0000305}.
DR   EMBL; U15593; AAA82583.1; -; mRNA.
DR   PIR; JC4201; JC4201.
DR   RefSeq; NP_001003303.1; NM_001003303.1.
DR   RefSeq; XP_005636738.1; XM_005636681.2.
DR   RefSeq; XP_013963722.1; XM_014108247.1.
DR   RefSeq; XP_013963723.1; XM_014108248.1.
DR   RefSeq; XP_013963724.1; XM_014108249.1.
DR   RefSeq; XP_013963725.1; XM_014108250.1.
DR   UniGene; Cfa.3856; -.
DR   ProteinModelPortal; P52211; -.
DR   SMR; P52211; -.
DR   STRING; 9615.ENSCAFP00000016137; -.
DR   PaxDb; P52211; -.
DR   Ensembl; ENSCAFT00000039639; ENSCAFP00000035520; ENSCAFG00000010955.
DR   Ensembl; ENSCAFT00000049938; ENSCAFP00000035896; ENSCAFG00000010955.
DR   GeneID; 403987; -.
DR   KEGG; cfa:403987; -.
DR   CTD; 5744; -.
DR   eggNOG; ENOG410IW2I; Eukaryota.
DR   eggNOG; ENOG41126XH; LUCA.
DR   GeneTree; ENSGT00390000004933; -.
DR   HOGENOM; HOG000115765; -.
DR   HOVERGEN; HBG003236; -.
DR   InParanoid; P52211; -.
DR   Reactome; R-CFA-373080; Class B/2 (Secretin family receptors).
DR   Reactome; R-CFA-418555; G alpha (s) signalling events.
DR   Proteomes; UP000002254; Chromosome 27.
DR   Bgee; ENSCAFG00000010955; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0005179; F:hormone activity; IBA:GO_Central.
DR   GO; GO:0051428; F:peptide hormone receptor binding; ISS:UniProtKB.
DR   GO; GO:0007189; P:adenylate cyclase-activating G-protein coupled receptor signaling pathway; IBA:GO_Central.
DR   GO; GO:0002076; P:osteoblast development; IBA:GO_Central.
DR   GO; GO:0032330; P:regulation of chondrocyte differentiation; IBA:GO_Central.
DR   InterPro; IPR003626; PTH-rel.
DR   InterPro; IPR001415; PTH/PTH-rel.
DR   PANTHER; PTHR17223; PTHR17223; 1.
DR   Pfam; PF01279; Parathyroid; 1.
DR   SMART; SM00087; PTH; 1.
PE   2: Evidence at transcript level;
KW   Calcium; Cleavage on pair of basic residues; Complete proteome;
KW   Cytoplasm; Hormone; Nucleus; Reference proteome; Secreted; Signal.
FT   SIGNAL        1     24       {ECO:0000255}.
FT   PROPEP       25     34       {ECO:0000250}.
FT                                /FTId=PRO_0000023220.
FT   CHAIN        37    177       Parathyroid hormone-related protein.
FT                                /FTId=PRO_0000023221.
FT   PEPTIDE     143    175       Osteostatin. {ECO:0000250}.
FT                                /FTId=PRO_0000023222.
FT   REGION       57     68       Important for receptor binding.
FT                                {ECO:0000250}.
FT   MOTIF       108    129       Nuclear localization signal.
FT                                {ECO:0000250}.
SQ   SEQUENCE   177 AA;  20299 MW;  93F57235C188A2CD CRC64;
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